@RobHoffman_ It’s got a whole lot more deuterium. Which might give you a short term lift, but have issues over the long term.
Not a good choice for mitochondrial health…. Which means overall health.
Minor parties matter!
In our democratic system it’s incredibly important that major parties are held to account.
They all inevitably become influenced by careerists, lobbyists and vested interests.
When I started People First it was with the intention of holding the major parties to account.
That intention has never changed and is just as important today even with the rise of One Nation.
While it will be good for the Uniparty to be destroyed, it’s important that whatever party replaces it is also held to account.
Good governments need to have the capacity to implement solutions and a vision for our future. They also need to be able to manage the bureaucracy and the government machinery they control.
It’s not good enough for someone that wants to be Prime Minister not to turn up to Senate estimates or inquiries. Changing the way government works is going to take hard work, persistence and patience.
You need to make sure that government employees carry out the tasks you require of them and to hold them to account when they don’t.
To do that you need both analytical and persuasion skills. Furthermore you need to be constantly engaging with them on a face to face basis so they know they are being watched.
If you can’t hold the bureaucracy to account as a backbencher in Senate estimates when you have time to prepare questions then how do you expect to hold them to account when they are crossing your desk everyday as Prime Minister?
Any opportunity to hold the bureaucracy should be taken up with glee, not spurned.
That’s why supporting https://t.co/rzwZyRkFsH is so important.
We have the vision for today and the vision for tomorrow. More importantly we have the capacity and the work ethic to hold the government to account regardless of their ideology.
If you would like to help People First continue to hold the government to account, whatever their persuasion please donate today at https://t.co/PeAaJW2pjF
Deuterium — a variable almost nobody tracks — regulates cell growth and mitochondrial function.
It sits upstream of cancer and everything downstream.
Your mitochondria maintain a lower deuterium concentration inside their inner membrane than outside.
That gradient is not incidental.
It's a feature of normal mitochondrial function.
Roman Zubarev — professor of medical proteomics at the Karolinska Institute, trained at Moscow's elite physics institute — has spent years studying what happens when you disturb it.
1. Deuterium As A Cell Growth Regulator
Deuterium — heavy hydrogen — regulates cell growth rate in the range of approximately 30–350 ppm.
Earth's normal deuterium concentration is around 150 ppm.
When cells are deprived of this normal amount, their growth slows down.
To test this, Zubarev’s lab used A549 lung cancer cells — currently the most widely used cell line in biology — and exposed them to deuterium-depleted water at about 80 ppm.
The result?
Cancer cell growth rate dropped by 30%.
Once deuterium concentrations step outside of that 30–350 ppm regulatory window, the effects stop being regulatory and start becoming highly detrimental.
For example Mars carries approximately 750–1,050 ppm of deuterium—roughly 5 to 7 times Earth's natural concentration.
When terrestrial organisms are exposed to Martian deuterium levels, they show significant survival decline.
Zubarev’s team conducted a two-year experiment growing small shrimp in isolated environments where the water was modified to contain ~600 ppm of deuterium.
They found that the survival rates of the shrimp significantly declined compared to those grown in normal water.
2. The Mitochondrial Mechanism — How Deuterium Depleted Water (DDW) Actually Works
Alongside the well-known proton gradient, there is also a deuterium gradient across the inner mitochondrial membrane.
Normally, the concentration of deuterium is lower inside the membrane than it is outside.
Mitochondrial lipids are naturally deuterium-depleted.
When cells are placed in 80 ppm deuterium-depleted water — lower than the normal ~150 ppm outside — the gradient reverses.
More deuterium inside the membrane than outside.
So how does this reversal suppress growth?
This reversal upsets reactive oxygen species (ROS) production.
To try and restore equilibrium, the mitochondria rapidly increase their production of ROS.
This sudden spike in ROS induces oxidative stress within the cell, which the researchers identified as the primary molecular mechanism that ultimately suppresses the growth of the cells.
This is the anti-cancer mechanism.
Zubarev: "We have not invented this mechanism — it's very well known."
To prove that DDW suppresses cancer cell growth by inducing oxidative stress they added NAC — N-acetylcysteine, a standard antioxidant — to DDW-treated cancer cells.
If DDW works through ROS, an antioxidant should cancel the effect.
The result?
At approximately 2 millimolar NAC, the DDW anti-cancer effect was statistically eliminated.
Then they tested the reverse.
They combined DDW with auranofin — a drug that induces oxidative stress.
If both work through ROS, combining them should produce synergistic effect.
The result?
At low to medium concentrations, adding the drug to the DDW created a "double whammy effect" where the cell count went down even further.
However, at very high concentrations of the drug, the effect of the DDW diminished, which Zubarev explains makes sense because a cell does not need two overwhelming sources of reactive oxygen species to die.
Three-layer validation.
Published in Molecular and Cellular Proteomics — the top proteomics journal.
3. The Antioxidant Implication
Standard health messaging treats ROS as purely bad.
Antioxidants good. Oxidative stress bad.
Zubarev's data complicates this directly.
DDW works by increasing ROS in cancer cells.
Antioxidants statistically cancelled the therapeutic effect.
Auranofin — an oxidative stress inducer — synergized with DDW against cancer.
Important caveat: this finding is in cancer cells, not in healthy humans.
Zubarev notes that normal human cells react differently, stating that normal human cells are much less sensitive to DDW.
Therefore, the induction of ROS to slow down growth is a therapeutic mechanism specifically observed in fast-growing cancer cells, not a general effect reported for healthy cells.
But the blanket "antioxidants are good" narrative fails here.
Context determines whether ROS is friend or enemy.
4. You Are Not What You Eat
The standard model of nutrition assumes the body passively absorbs its dietary inputs — including isotopic composition.
Zubarev's data shows the opposite.
The body actively resists changes to its internal isotopic composition.
It defends a specific ratio the way it defends pH or temperature.
Isotopes modulate their own fractionation — the biological system selectively processes and separates heavy and light isotopes to maintain equilibrium.
The isotopic quality of what you eat and drink is a regulated biological input — not a passive one.
For example, the deuterium levels found in the proline, hydroxyproline, and collagen of seals are twice as high as the deuterium levels in the surrounding seawater.
Because the isotopic concentration in the seals' biological building blocks is double that of their environment, there is no way to attribute this composition simply to their food.
5. Isotopic Resonance — The Order Underlying Life
Plot the isotopic masses and abundances of the elements that make up biological molecules — hydrogen, carbon, nitrogen, oxygen.
You'd expect random scatter, a scattered "galaxy" of dots.
Instead you find a precise line.
Zubarev calls it isotopic resonance.
At natural isotopic abundances, biological molecules cluster in a specific ratio that produces the simplest, most efficient molecular conformations.
That ratio is the point at which life's chemistry runs fastest.
The probability of this pattern appearing by chance is astronomically small.
Zubarev — a physicist trained in probability — cannot dismiss it:
"This is the line of God, if you want."
Life doesn't exist here just because of liquid water and moderate temperature.
It exists here because Earth's isotopic composition happens to hit the resonance at which life's machinery runs.
Disturb that composition — and the system works to defend it.
The isotopic quality of your water, your food, and your environment is not a background variable.
It is the upstream input everything else depends on.
@Mark_Butler_MP@elizabethhart
Very pertinent question, as the mandated jab rollout (and subsequent loss of jobs and access to normal life) had been underway for months. https://t.co/AxBwZKiyxo
@HiltonRyanD@DrJackKruse Zamora’s epic description of his theory of the ice sheet’s impact explosion and then the raining down of ice bombs was incredible.
The closure of rail services in regional Queensland is just another sad indictment on the state of our nation.
While countries in Asia are building high speed rail and nuclear power plants, our governments can’t even keep existing services going with aging rolling stock.
There’s money for the Olympics of course, but nothing for the regions that generate our wealth.
The closure of the Westlander is particularly harsh because as the Chareville mayor quite rightly points out, regional towns like Chinchilla, Chareville and Cunnamulla were built on the back of rail.
It’s not like the government has put money into roads either, with the Bruce and Warrego highways being virtual death traps.
This debacle can be traced back to the privatisation of the Queensland rail coal trains back in the early 2000’s under the Bligh government. (Fun fact - Murray Watt was her chief of staff.)
These coal trains generated income that was used to fund passenger services.
The solution for this is to start funding the construction of infrastructure such as rail to generate income to pay for essential services.
https://t.co/PeAaJW2pjF is advocating for an Infrastructure bank to fund this construction through domestic bonds rather than foreign debt.
We are also advocating to start a military apprenticeship scheme to ensure that our children have the skills to build infrastructure rather than rely on foreign contractors that is being used for Snowy 2.
It’s not rocket science - If we want to get our country back on track we have to get back on the tools and start building. No ifs, no buts.
@Alex753429@AlboMP I remember reading stories about historical england, Scotland, Ireland and Europe, where farm “tenants” had to give up a large percentage of the goods and livestock they raised and thought it was unjust and a kind of tenured slavery…
Sadly it took me years to see the similarity
@rodunn@EricLDaugh Cancer research has been very serious since late 50’s. Since SV40 found in polio vaccines.
Sadly, it has grown exponentially and pharmaceutical treatments to are now the one of the biggest growth industries in centralised medicine.
I’m getting feedback that seems to justify multinationals shifting profits offshore because our taxes are too high here in Australia.
Government waste aside, our taxes are too high because of profit shifting. If multinationals paid more tax here, Australians would pay less.
Furthermore this issue has only gotten worse as foreign investors have been allowed to buy our Infrastructure, farmland and housing.
https://t.co/PeAaJW2pjF policy is to level the playing field by shifting the tax burden onto companies that shift profits offshore.
Transfer pricing is difficult to monitor given the millions of transaction that occur on a daily basis. The easiest way to stop profit shifting is to lift the rate of tax on profits sent offshore to fund a CUT IN THE TAX RATE HERE IN AUSTRALIA.
This is the very essence of putting the Australia People First.
An easy way to tell if multinationals are shifting their profits offshore is to compare the operating profit ratio of their operations in Australia verses their worldwide operating profit.
Pfizer for example had an operating profit ratio of just 7% in Australia verse 35% for its worldwide income.
This was on $1.4 billion in sales of which a billion was transferred to Ireland.
Australia withholds only 10% on royalties paid to Ireland, despite Ireland having a company tax rate of 12.5%.
A total tax burden of 22.5% which is 7.5% less than the 30% applied to company tax in Australia. Sending profits to Ireland saves Pfizer 7.5% of a billion dollars or $75 million.
It is therefore clearly obvious that any company will shift profits to Ireland (and numerous other countries with that Australia applies low withholding rates too.)
https://t.co/PeAaJW2pjF is the only party that has the knowledge to crack down on profit shifting to fund a cut in taxes here in Australia.