Montserrat Anguera @montserrat-anguera.bsky.social

Associate Professor @PennVet studying X Chromosome Inactivation and sex differences of immune system & beyond. She/her. Comments/views my own.

[Montserrat Anguera @montserrat-anguera.bsky.social @montserrat]

#LupusResearch #Immunology #Genetics #XChromosome #WomenInScience @CellReports @LupusResearch @pennvet @PennMedicine

[Montserrat Anguera @montserrat-anguera.bsky.social @montserrat]

Why do women develop lupus more often than men?
Our new study provides intriguing evidence that one key player may be hiding in plain sight: the X chromosome. We found that deleting Xist in B cells of female mice can trigger lupus-associated phenotypes. 🧬 https://t.co/zHPr2RRooE

[Montserrat Anguera @montserrat-anguera.bsky.social @montserrat]

Take-home message: Xist deletion in the B cells of female mice can promote lupus-associated immune abnormalities, supporting a role for XCI in protecting against autoimmunity. Sometimes the genes you express are just as important as the ones you silence.

[Montserrat Anguera @montserrat-anguera.bsky.social @montserrat]

Our paper reveal a unique mechanism of XCI maintenance unique to B cells, where PRC1 and PRC2 travel independently across the inactive X with different requirements for Xist RNA!

[Montserrat Anguera @montserrat-anguera.bsky.social @montserrat]

New paper alert from the Anguera Lab @CellReports! @n_toothacre uncovered a unique requirement for Xist RNA of X-Chromosome Inactivation in B cells! A 🧵of our findings 👇 https://t.co/VsH93EFrEe

[Montserrat Anguera @montserrat-anguera.bsky.social @montserrat]

Does H2AUb rely on PCR2 to accumulate on the inactive X post-stimulation? NOPE! Inhibiting PRC2 reveals that H2AUb enrichment is solely dependent on Xist RNA, not PRC2 activity.

[Montserrat Anguera @montserrat-anguera.bsky.social @montserrat]

Check out our latest review article by awesome @CAMBUpenn MSTP student @claudia_lovell: More X’s, more problems: how contributions from the X chromosomes enha... https://t.co/DYr0AMJDE1

[The Lincoln Project @ProjectLincoln]

Anyways...

Holland Office
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Portage Office
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Washington, D.C. Office
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[PayerLab @PayerLab]

@montserrat @n_toothacre @claudia_lovell @CAMBUpenn @PennEpiInst @ericjoycelab @CreminsLab Congratulations - beautiful work! Anguera lab is on an X-cellent streak right now 👏💪

[Montserrat Anguera @montserrat-anguera.bsky.social @montserrat]

📣New paper alert from the lab! Lab alumni Isabel, @n_toothacre, @claudia_lovell from @CAMBUpenn together with @PennEpiInst faculty @ericjoycelab @creminsLab investigate 3D ultrastructure of the inactive X in B cells. https://t.co/KsUFpetcpo

[Montserrat Anguera @montserrat-anguera.bsky.social @montserrat]

New preprint from the lab! Incredible allele specific profiling of the inactive X in B cells by the incredible @n_toothacre! check it out 👇
https://t.co/VVLTzMwkAy

[Montserrat Anguera @montserrat-anguera.bsky.social @montserrat]

Our study demonstrates that NF-kB signaling contributes to XCI regulation, thereby adding to our understanding of female-biased immune responses involving T cells. Thanks to our awesome collaborators Mike May, @nromberg_ and NF-kB patients & samples!

[Montserrat Anguera @montserrat-anguera.bsky.social @montserrat]

New Anguera Lab paper alert @SciImmunology! @thatsdrpox2you @n_toothacre discovered a new connection between X-Chromosome Inactivation and NF-kB signaling in T cells. A 🧵 of our findings 👇https://t.co/QcoNiAcn1G

[Montserrat Anguera @montserrat-anguera.bsky.social @montserrat]

One signaling pathway downstream of T cell receptor activation is the canonical NF-kB pathway. We discovered that chemical inhibition or genetic deletions that block NF-kB signaling prevents Xist RNA ‘clouds’ in mouse and human T cells, and altered X-linked gene expression!