🚨New preprint from the lab🚨
🧬 What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide HiDRO screen uncovers a key role for RNA-binding protein hnRNPK.
https://t.co/KGTUAZqHyS
We’re excited to share that, after receiving many requests each year from the research community for Oligopaint DNA & RNA FISH probes, we’re piloting a service to design & prepare probes for labs.
Please share with colleagues who may benefit! https://t.co/883BTy3MKw
Dr. Randi Isenhart (@isenhartrandi) has a new 1st author publication for her work in the @ericjoycelab on: The length and strength of compartmental interactions are modulated by condensin II activity: https://t.co/FmiCnloM28
We are deeply saddened by the loss of an esteemed colleague, friend, mentor & a pioneer in Drosophila & meiosis research.
R. Scott Hawley was a dedicated supporter of GSA & a champion of genetics.
Read an In Memoriam published in Genes to Genomes: https://t.co/Nabrvgthv7
Exciting news 📃🧬🔬 Today we report on the dynamics of a fascinating class of molecular motors, so-called SMC proteins in @CellCellPress
https://t.co/MRIIHE893Z
Excited to share our latest work on bioRxiv! Using cell-cycle dynamics and NIPBL depletion, we show that long-range enhancer interactions can form de novo without loop extrusion. Alternative mechanisms, including LDB1 and YY1, may play key roles.https://t.co/CgBN4QJcuL
Congratulations @HarshiniChandr8 💐
Using human neurons homozygously-engineered with familial AD mutations, she found a role for miswired promoter-enhancer multi-loops in dysregulated excitatory and inhibitory gene expression programs
BioRxiv: https://t.co/JymYYJdcId
It's my pleasure to present the next big preprint from SheqLab! An exciting application of our O-MAP platform that I hope will transform the study of nuclear architecture.
If you've ever wanted to dissect the subnuclear "neighborhood" around an individual locus, read on! (1/30)
Happy to share work with Hadi, Yao & @Maxime_Tortora characterizing the impact of dynamic CTCF barriers for cohesin loop extrusion
https://t.co/iiaiJg2ZeB
First preprint from the lab 🚨
How can enhancers regulate target promoters across vast genomic distances, and what is the role of cohesin loop extrusion in the process?
https://t.co/l7bwPsTSkd
(1)
Excited to share a new preprint!
(1)🔬The nucleolus is the most prominent nuclear condensate, with a fascinating multilayered liquid-like structure, and is the site of ribosome biogenesis. But how does this multiphase architecture form and function?
https://t.co/xKP9tGFFlQ
1/🧬Does chromatin organization shape immune responses? Our recent study with @NickAdams_PhD led by Reizis Lab and @leonidmirny explores how cohesin, a key player in chromatin loop extrusion, controls the chromatin architecture essential for conventional dendritic cells (cDC)👇
📣Sharing the latest research from the @MRSantosLab, just released on bioRxiv! We found LINE1 RNA promotes nuclear compartmentalization to repress the 8-cell state in human embryonic stem cells.
https://t.co/uE06Xx3QcY
👇Key findings:
We then show these changes are found within tissues and during aging. To learn more, check out our preprint!
Thank you to all co-authors, the Buenrostro lab, and everyone at @HSCRB & @broadinstitute who made this work possible!
https://t.co/sim05C81m0
Speaker Spotlight: @MariekeOudelaar from the Max Planck Institute will share exciting research on the mechanisms behind 3D genome folding and its role in gene regulation during cellular differentiation. Don't miss it! Register here 👉 https://t.co/xHZSamYZuq #chromatin2024