Peter Ly

Genome Integrity Lab | Associate Professor @CRI_UTSW @UTSWMedCenter. We study how mitotic errors and genomic instability drive cancer evolution.

[Karim Mekhail @KarimMekhail]

Happy to share our latest preprint on how the human DNA damage response drives nuclear metamorphosis (nucleomorphosis) and its role in DNA repair via a molecular code distributed on cytoskeletal and membrane-related elements.
https://t.co/Qayge9BdTP

[J Cell Science @J_Cell_Sci]

When cells in different phases fuse, nuclei play a mitotic tug-of-war

Olga Afonso, Daniel Feliciano and Jennifer Lippincott-Schwartz investigate the fate of syncytia containing nuclei at different cell cycle stages.

Highlight: https://t.co/SKpcuboIKI

[Tatsuo Fukagawa @tatsuofukagawa1]

Our recent paper on CCAN organization was just out in @ScienceAdvances. We combined MD simulation with expansion microscopy to observe an interesting structure in the kinetochore. Congrats, @yj_sakai, Mariko, and @yasuhhirano17 !! Please check it out.
https://t.co/zZF4FNHJ1z

[Rémi Buisson @RemiBuisson]

The Department of Biological Chemistry at UCI is seeking a tenure-track Assistant Professor!

This is a broad search across biomedical sciences, including genome stability. Join a dynamic department with great faculty benefits and year-round sunshine!

https://t.co/xLAkV0NxOA

[Binyam Mogessie ቢንያም ሞገሴ @BinyamMogessie]

Out today in @JCellBiol Work from the Mogessie, @FachinettiLab & @DrSteffi labs reveals how CENP-A/B/C cooperate to maintain kinetochore function in oocytes and how declining centromere strength predisposes aging eggs to aneuploidy. @pewhealth @HFSP

https://t.co/Q2hYFCL9i1

[Hao Zhu Lab @Zhu_Lab]

We are looking to hire post-doctoral fellows to work on somatic mosaicism, regeneration, and cancer development, please reach out to me if you are interested! @CRI_UTSW

[Anton Henssen @anton_gh]

Happy to share our new study published this week in @NatureGenet 🔥🔥🔥🔥

https://t.co/6UMv68vo4e

[Peter Ly @PeterLyLab]

@pipcosper @TheMarkFdn Congrats Pippa! You’re awesome 😎

[Peter Ly @PeterLyLab]

That’s a wrap for FASEB Aneuploidy 2026! Thanks to all the attendees for making it a special meeting. The science was so out-of-this-world that NASA even launched a spaceship for us. 🚀

See you again in 2029! #ANESRC

[Children’s Research Institute at UT Southwestern @CRI_UTSW]

🔬TWO MORE WEEKS remain to apply for any of our three open faculty positions at https://t.co/fX7rO4zTmq #relentlessdiscovery

[Ross Chapman @Chapman_lab_UK]

Check out our latest, just out in @MolecularCell! We reveal how typically harmless forms of DNA damage synergise with DNA replication defects in ATM-deficient cells to drive cancer responses to PARP inhibitors—and propose that a similar synergy may contribute to A-T pathogenesis.

[Peter Ly @PeterLyLab]

We are recruiting new faculty at all levels who seek to solve fundamental problems in biology and disease. @CRI_UTSW is an exceptional and highly collaborative environment to build a research program and pursue ambitious science. Join us!

[Karim Mekhail @KarimMekhail]

😊 New preprint! In budding yeast, Dna2-intrinsic condensation regulates long-range DNA-end resection. Analyses suggest redistribution of condensate grammar in humans. Congrats to Chris Jordan and the Mekhail, Wyatt, Cowen & Hakem labs! More to come soon.

https://t.co/0MR2Jr9LSI

[Yuan He @YuanHeJHU]

A big week for the lab! Two new papers on how cells repair DNA double-strand breaks: one on getting NHEJ started in chromatin, one on processing the ends before ligation. Years of work by a fantastic team.

[Nature Reviews Molecular Cell Biology @NatRevMCB]

New Online! Mechanisms and disease relevance of DNA break repair pathway choice https://t.co/67wHM3gHY3

[Kazuhiro Maeshima @kazu_maeshima]

How are mitotic chromosomes built? 🏗️ Our Review @TrendsGenetics revisits the classical chromosome scaffold model and connects it to condensins, topoIIα, and physical forces. We propose interphase chromatin domains as “building blocks”🧩of chromosomes:
https://t.co/AQgiZlSjYS

[Anton Henssen @anton_gh]

Very happy to share our new Perspective in Nature Reviews Genetics, led and written primarily by my colleague Liam P. Shaw:

“The shared evolutionary capacities of plasmids and extrachromosomal DNA”

https://t.co/Y0lwYwrJdO

[Peter Ly @PeterLyLab]

@SZhang_Lab @EmmaAleksandr97 Congrats Siyuan, Emma, and colleagues!

[Alexander Kelly @AlexKellyLab]

Excited to share our new @ScienceAdvances paper! During interphase, centromeres form 3D shells organized by the CENP-A chaperone complex at their core. Led by Hindol Gupta, with the @TakashiAkeraLab , Losada, and Shroff labs.

https://t.co/Fs3C0lCepW

[Arvind Panday & Lab @pandayarvind441]

🎉 Excited to share the first preprint from the Panday Lab!
https://t.co/bTPXUqbz32

We identify FANCM as an adaptive genome-maintenance dependency in BRCA1-deficient breast cancer and uncover its role in restraining ongoing structural genome evolution.