Hao Zhu Lab

Physician-scientist at @CRI_UTSW with a focus on #LiverCancer and organ regeneration.

[Hao Zhu Lab @Zhu_Lab]

Somatic mutations accumulate in “normal” non-cancerous tissues (blood, skin, liver). But why are mutant clones selected? Do they merely proliferate more, selfishly? Or can clones adapt to disease? Could they protect tissues? We shed light on this: https://t.co/Vu1d4U3stc 1/10

[Peter Ly @PeterLyLab]

The Ly Lab @CRI_UTSW is recruiting two #postdocs to study intercellular DNA transfer. Join us to tackle fundamental questions at the intersection of genome instability, cell-cell communication, and cancer evolution. Please share! 🙏

Full posting: https://t.co/INoSPaqx95

[Children’s Research Institute at UT Southwestern @CRI_UTSW]

🚨Seeking 2 #postdocs ⬇️ join the #relentlessdiscovery

#ScienceJobs #SciJobs #JobRxiv #STEMJobs #AcademicTwitter #PhDJobs

[Allison Fitzgerald, MD, PhD @allisonoconn]

With all the excitement around daraxonrasib, I needed to refresh my RAS inhibitor knowledge, so here we go:

[Eric Topol @EricTopol]

We have hundreds of PanINs in our pancreas, especially after age 40. They are a pre-cancerous lesion, but it is fortunately rare for one to progress to cancer (PDAC). Now we know a reason for that. The microenvironment. @umichmedicine @UMRogelCancer
https://t.co/Wl3Ys6kkzJ @CD_AACR

[Children’s Research Institute at UT Southwestern @CRI_UTSW]

ONLINE NOW in @CellCellPress: @PeterLyLab has discovered large pieces of DNA can transfer directly between human cells & that DNA can persist, change how the recipient cell functions. Read more about this #relentlessdiscovery ⬇️ https://t.co/cmNRqAfXaR

[Cancer Cell @Cancer_Cell]

Molecular insights into early malignant transition of hepatocellular carcinoma https://t.co/uSYBBkFJRC

[Pradeep Natarajan @pnatarajanmd]

Our preprint led by @M_Mesbah_Uddin @ZhiYu_ACGT and with @AlexBickMDPhD describes the germline genetic drivers and phenotypic associations of clonal hematopoiesis of indeterminate potential across >1M individuals https://t.co/f5HDVlBeqr @medrxivpreprint

[Hao Zhu Lab @Zhu_Lab]

@CRI_UTSW @WashU congrats Greg on a great thesis! we are going to miss you!

[Children’s Research Institute at UT Southwestern @CRI_UTSW]

#thesisThursday: Been a week since Greg Mannino from @Zhu_Lab successfully defended! Congrats, Dr. Mannino 😎 and best of luck continuing the #relentlessdiscovery as a postdoc at @WashU.

[Hao Zhu Lab @Zhu_Lab]

@naxerova @NatureGenet very excited to dig into this! congrats to your team!

[Kamila Naxerova @naxerova]

A gene is recurrently mutated in cancer. But do these mutations really cause the disease? Or are they merely selected during normal tissue evolution?

Here we use a surprising data type (patient ages!) to try and answer this question.

Read new paper out @NatureGenet

👇🏻

[Roxanne Khamsi @rkhamsi]

This week marks the release of my book Beyond Inheritance 🎉 📖. It tells the stories of patients with mysterious ailments who have been saved by a radical new view of genetics. And how whales can teach us about preserving our DNA as we age. Available now: https://t.co/7PAsddHAge

[Kentsis Research Group @KentsisResearch]

Monday-Tuesday May 4-5 2026 Steel Symposium in Developmental Oncology @MSKCancerCenter #MSKKids https://t.co/tQHnx5KkkV

[Aron Jaffe @jaffeab]

Congratulations to the now Twitterless/Xless Ralph DeBerardinis on being elected to @theNASciences!!!

[Carlos L. Arteaga, M.D. @CarlosArteagaMD]

Great accomplishment, @EChenLab, a member of @utswcancer!
https://t.co/V7co8d4imH

[Children’s Research Institute at UT Southwestern @CRI_UTSW]

ONLINE NOW in @NatMetabolism: McBrayer Lab & first-author @milan95 have discovered cell maturity determines pyrimidine synthesis pathway preference using their new nitrogen metabolism profiling platform, organoid model. Read more ⬇️
https://t.co/6XDwzYynti #relentlessdiscovery

[Pradeep Natarajan @pnatarajanmd]

Cool work from @ChrisAWalsh1 showing enrichment of somatic driver mutations (in TET2, ASXL1, DNMT3A) linked to clonal hematopoiesis in hematopoietic-derived microglia-like brain macrophages in brain samples from pts w Alzheimer’s Disease v controls https://t.co/XZLB9UDJAz @CellCellPress

[Children’s Research Institute at UT Southwestern @CRI_UTSW]

🌟From the desk of @SJMorrison_: It's a great day for CRI, which now has 2 @theNASciences members. Congratulations to Ralph DeBerardinis, M.D., Ph.D., and his laboratory on this recognition for the quality and impact of their work! #relentlessdiscovery
https://t.co/drqKPSLL3z

[Dr. Len Zon @leonard_zon]

Congrats to my friend and colleague, George Daley, for his induction into the National Academy of Sciences.

[National Academy of Sciences @theNASciences]

Congratulations George Q. Daley of @harvardmed, newly inducted #NASmember! #NAS163 #medicine #biology #oncology