Aron Jaffe

SVP @ SVP Head of Research @chromamedicine;EIR @ThirdRockV;Reg Med, uBiome group leader/Resp DA co-lead @NovartisScience. Opinions mine

[Aron Jaffe @jaffeab]

Our work describing the development of a potent epigenetic editor targeting human #PCSK9 for durable reduction of LDL-C is out in @NatureMedicine today!
Cc: @chromamedicine @nchromabio
1/9

https://t.co/cnelNtMT0W

[Samuel Hume @DrSamuelBHume]

Extremely cool chart: the emergence of medicines for cystic fibrosis, and the subsequent climb in life expectancy from <30 years to ~normal.

[Aron Jaffe @jaffeab]

I <3 genetics

[NEJM @NEJM]

Presented at #TLM26:

A single dose of an siRNA targeting liver expression of 𝘊𝘐𝘋𝘌𝘉 was associated with a reduction in liver fat of 58 to 80% at week 36 after treatment in persons with metabolic dysfunction–associated steatotic liver disease. Full trial results: https://t.co/gQfFsMwWG2

@AASLDtweets

[michael @worstmichael]

Brewers World Series victory has evidently closed the portal to Hell opened by the Cubs 2016 title. Our long national nightmare is over

[Aron Jaffe @jaffeab]

Live Forecast: Senate and House https://t.co/WHZIziPtow via @NYTimes

[Aron Jaffe @jaffeab]

How Trump Is Dismantling America’s Scientific Research Machine https://t.co/k2zUN8gtTY via @NYTimes

[Xavier Lab @TheXavierLab]

New paper in @NatureMedicine with @KimmieNgMD and @AnaAndersonlab! Early-onset colorectal cancer (#EOCRC) is rising. Our single-nucleus atlas of 189 tumors reveals age-associated differences and offers a resource for further research.
https://t.co/JEEAtbveWg

[Hao Zhu Lab @Zhu_Lab]

We are looking to hire post-doctoral fellows to work on somatic mosaicism, regeneration, and cancer development, please reach out to me if you are interested! @CRI_UTSW

[Baseball Quotes @BaseballQuotes1]

“They may have a bunch of Hall of Famers, but we have a bunch of gamers.”

what a mf BAR

[Aron Jaffe @jaffeab]

Very sad to see this. RIP @HelenBranswell

https://t.co/LMEtLsjOua

[The Wieners Circle @TheWienerCircle]

Cream calls the shots for the free 🌭s. If Ben Johnson rocks the sweater and da Bears win free hot dogs all day Tuesday
RIP to da coach

[Jay Shendure @JShendure]

Exciting day for DNA Typewriter w/ 2 papers from the lab & SeaHub out today :)

1. Mouse lineage from E0 to E13.5
https://t.co/wTVo9mHQ5P
2. A fluctuation test for gastruloid heterogeneity
https://t.co/hkXNM9lgZK

Paper #1 covered in quoted thread. More on paper #2 here. 1/n

[Jonathan Weissman's Lab @JswLab]

Thrilled to share that our work reconstructing a cell fate map of the mouse embryo is out now in @CellCellPress! https://t.co/AnAlTivwNp

[Aron Jaffe @jaffeab]

RIP

https://t.co/praVd6uj3x

[Hepatic Cell News @hepaticcellnews]

Approved chronic #HepatitisB therapies rarely result in functional cure.

🥼 Scientists at @nchromabio are tackling this with CRMA-1001; it employs an optimized epigenetic silencer and preclinical findings support its potential for a finite treatment course and functional cure.

Read more in the #OpenAccess article published in @natBME: https://t.co/cuHKz8kdgo

[Paras Sharma @paras_biotech]

What triggers growth in rare disease prevalence: a case study perspective

A rare disease market can grow without the disease becoming more common. Trials, treatments and better reporting can reveal patients who were already there.

[Daniel Heller @Dan_A_Heller]

So excited to be part of this incredible work out today in @ScienceMagazine on how P-selectin-targeted anti-senescence nanotherapy can fight fibrotic conditions and cancers. Congrats to @LoweLabMSKCC and @hellerlab members and others @MSKCancerCenter!! https://t.co/IMPeM3VM5h

[Micha Breakstone @MichaBreakstone]

At @CellularIntelHQ, we're building a universal foundation model of cell signaling to understand, predict and ultimately control how cells behave.

Grateful to welcome @ylecun, Bob Langer, Jens Nielsen and @fabian_theis to our Scientific Advisory Board.

https://t.co/WOrECjnoIl

[Cellular Intelligence @CellularIntelHQ]

Today we officially welcome Yann LeCun (@ylecun), Bob Langer, Jens Nielsen and Fabian Theis (@fabian_theis) to the Cellular Intelligence Scientific Advisory Board. Langer also joins our Board as an observer.

Four people who have changed what is possible in AI, biology and medicine, now working with us to learn the rules that govern how cells change, and carry that knowledge into medicine.

@FortuneMagazine's @CatGioino has the story: https://t.co/sCZH6rKKfA

[Aron Jaffe @jaffeab]

Proud to see this work out today in @natBME, describing the development of an epigenetic editor for chronic hepatitis B. Congrats to the X-less Yesse Anglero-Rodriguez, John Xiong, and all who contributed @chromamedicine -> @nchromabio

https://t.co/Illw8MNaFB

[Aron Jaffe @jaffeab]

This 100x

https://t.co/Iq9yr6joTd