ShorterLab

Countering deleterious phase transitions in ALS/FTD, PD, AD, and related disorders @Penn @PennMedicine @bb_upenn @BMBGGUPENN @PGGUPenn @PennNGG @CAMBUpenn

[ShorterLab @ShorterLab]

Biased stochastic motor dynamics drive bidirectional, processive translocation by the AAA+ disaggregase Hsp104: https://t.co/X5OVu6h6ui

[Subhojit Roy, MD, PhD @Roy_Lab_Thinks]

I'm obsessed with these empty clathrin cages people are seeing in neurons, and don't understand why others are not. So I put everything together and wrote a brief review (Current Opinion in Neurobiology, free access for 50 days):
https://t.co/hA4cmIiS0Q

[ShorterLab @ShorterLab]

Phosphorylation of α-Synuclein Directs Trafficking of the v-SNARE Synaptobrevin-2 https://t.co/h6yxauXepz

[ShorterLab @ShorterLab]

Cas9 nickase–mediated contraction of CAG/CTG repeats is associated with phenotypic improvements in a Huntington’s disease mouse model: https://t.co/jycoy6FxxY

[ShorterLab @ShorterLab]

Single-nucleotide polymorphism–directed design of allele-specific antisense oligonucleotides for spinocerebellar ataxia type 3: https://t.co/O08dmqVLvO

[ShorterLab @ShorterLab]

Persistent neuronal stress signalling underlies Angelman syndrome phenotypes: https://t.co/0IDVR8endm

[ShorterLab @ShorterLab]

Protein arginine methylation promotes global 3′UTR shortening in proliferating cells: https://t.co/ExoBpvBrSx

[ShorterLab @ShorterLab]

Running in reverse: Tau redirects mitochondrial electron flow toward neurodegeneration: https://t.co/rBoc2Oq1nO

[ShorterLab @ShorterLab]

PARG inhibition elicits cytotoxicity by sequestering XRCC1 and other PAR-binding proteins into PAR-dependent nuclear condensates: https://t.co/j7eGbRlFIx

[ShorterLab @ShorterLab]

Behind the Science: Digging for clues into the mechanisms of ALS https://t.co/CTIkrcRqTn

[ShorterLab @ShorterLab]

Fibres and glasses are competing material states in protein condensation: https://t.co/LtVLZPunlO

[Barstool Philly @BarstoolPhilly]

SIXERS BEAT KNICKS 106-100 IN SEASON OPENER AT MSG

TYRESE MAXEY WITH 28 POINTS

JAYLEN BROWN WITH 19, LEBRON JAMES WITH 14, AND JOEL EMBIID WITH 13

#THROWTHEBALLUP

PLAY THE SONG

[Philadelphia 76ers @sixers]

W.

[Philadelphia 76ers @sixers]

FIRST W OF THE SEASON.

@Bloom_Energy

[Philadelphia 76ers @sixers]

BUSINESS HANDLED.

[ShorterLab @ShorterLab]

An integrative transcriptomic atlas of ALS and aging skeletal muscle defines shared and distinct molecular programs of degeneration: https://t.co/pCqzlNayaQ

[ShorterLab @ShorterLab]

Heterogeneous amyloid β dimerization revealed by single-molecule FRET and MD simulation: https://t.co/1w9RVZvv6B

[Philadelphia 76ers @sixers]

#throwtheballup

[Philadelphia 76ers @sixers]

the time has come.

@Bloom_Energy

[Philadelphia 76ers @sixers]

meet the sixers. 🤝

[ShorterLab @ShorterLab]

Ataxin-2 downregulation rewires neuronal and astrocytic metabolism to protect against TDP-43 toxicity: https://t.co/rB7pJ11vCe