Bede Portz

Biotech. Interests: oncology, transcription factors, RNA, biomolecular condensates, RNA-binding proteins, neurodegeneration, aggregation, disordered proteins

[Bede Portz @YSPTSPS]

https://t.co/ekEjc6kSdc

[Rich Law @drrichjlaw]

Great interview & detailed explanation of going from a basic/foundational biological technology platform & pulling in some already established chemistry whose potential is highlighted by the platform, to accelerate into the clinic. $EIKN @EikonTX @bradloncar

[Kresten Lindorff-Larsen @LindorffLarsen]

Everything you wanted to know about the protein chemistry behind how amino-acid changes affect the cellular abundance of proteins

Effects of residue substitutions on the cellular abundance of proteins
https://t.co/FwoD1kiF30

[Bede Portz @YSPTSPS]

@andrewwhite01 @anshulkundaje I see you give a talk at an AI x DD meeting at the Broad a few years ago and I thought it was fantastic. Almost anti-hype. Gave, ‘listen, we are as shocked as anyone’s how well this stuff works,’ vibes. Been rooting for your company since.

[Bede Portz @YSPTSPS]

@JasonSynaptic @aemonten Yeah post EM acquisition and mass layoffs, the experience changed dramatically. Even prior to most science twitter folks leaving. There is still a critical mass of great biotech accounts, but for emerging science it is a shadow of what it was.

[Matthias Mann Lab @labs_mann]

1/5
Cell identity is written in the proteome, not in the DNA, and not always in the RNA. Out on bioRxiv today: The first cell type-resolved, MS-based proteomic atlas of the human body.
https://t.co/5RJ0nVoQ81

[Penn Medicine CSO @PennMedCSO]

ft. Katie Copley, Ashleigh Smirnov, Leland Mayne, @M_Linsenmeier, @JackRubien, @YSPTSPS, Bo Lim Lee, Hana Odeh, Longsheng Lai, @yiweichang Ben Black & @ShorterLab (@BB_UPenn) @ScienceMagazine https://t.co/8c5sX6fQlO

[Furqan Fazal @FurqanMFazal]

Excited to share our collaborative work with the @TonyMustoe and @SuperSciJew labs, led by the fearless @RitwikaBose15.
In this study, we developed RAID-MAP, an approach to map RNA structure within biomolecular condensates in living cells.
https://t.co/zUeJTnnEMV

[Sri Kosuri @srikosuri]

Published a piece outlining our approaches at OpenADMET where we are trying to build the CASP for small molecule ADMET prediction w/ @fraser_lab @BioSteve @lnhandly @jchodera @Mark_Murcko @wpwalters

https://t.co/cUA64QterB

[brangwynnelab @brangwynnelab]

Cool new video the Breakthrough Prize team put together featuring Tony @HymanLab and I describing the excitement and adventure of our discovery!
https://t.co/EdPwhG38Of

[Fyodor Urnov @UrnovFyodor]

I prompted the “deep literature” mode of Edison Scientific to write a comprehensive review on the biology of a gene that I know well.
Twenty five min later it sent a 17 page PDF. It was, as best as I can tell, flawless.
Folks, we are not in Kansas anymore.
Don’t at me - try it.

[Bede Portz @YSPTSPS]

@srikosuri Oh boy

[Állan Ferrari @ajrferrari]

Now available as its peer-reviewed version in Nature:

https://t.co/eV8gyVYJdk

[Brad Loncar @bradloncar]

Very excited to see @Nicole_Paulk’s hard work move this into the clinic!

[ShorterLab @ShorterLab]

For TDP-43 Aggregates, Breaking Up Is No Longer Hard to Do https://t.co/mNRNTiTtLZ

[Bede Portz @YSPTSPS]

As a person who did a postdoc in TDP-43 and RNA biology and who now works at a biotech focused on protein lipidation the 👀 emoji is apt.

[Molecular Cell @MolecularCell]

Online Now: S-acylation of TDP43 regulates its condensation in amyotrophic lateral sclerosis https://t.co/RmSOumT7Dr

[Bede Portz @YSPTSPS]

From @KevinRhine_ looks lit. https://t.co/EJXV27DtuQ

[Bede Portz @YSPTSPS]

@Nicole_Paulk @matthewherper @ArmstrongDrew California sober.

[Convoke @Convokebio]

Today we're publishing our index of unmet needs in human disease: 2443 indications scored and ranked on burden of disease, prevalence, pipeline activity, and treatment burden. We hope this will help drug developers identify overlooked medical problems

https://t.co/OX4BKC8cfI

[ShorterLab @ShorterLab]

Specialized RNA molecules could counter ALS neurodegeneration: https://t.co/mXQqcLMmx3

[Molecular Cell @MolecularCell]

Alu repeat-containing RNAs spatially organize actively transcribed genomic regions around nuclear speckles https://t.co/3eDxGZhj2u