Sofi Quinodoz

Mapping RNA & DNA organization in the cell | Assistant Professor @HopkinsMedicine HHMI Hanna H. Gray Fellow | Postdoc @brangwynnelab | Ph.D. @mitchguttman 👩‍🔬

[Sofi Quinodoz @sofiquinodoz]

So incredibly honored and thrilled to have been selected as a @HHMINews Hanna Gray Fellow! Huge thank you to so many – including my incredible mentors @brangwynnelab @mitchguttman and colleagues @Princeton @Caltech who I have been so lucky to work with! 🧬👩‍🔬
#HannaGrayFellows

[HHMI @hhmi_science]

Today, HHMI is proud to announce the new #HannaGrayFellows, 21 early career researchers who are taking on some of the biggest challenges in the life sciences. https://t.co/Ul5nuD9d17

[Lasker Foundation @LaskerFDN]

Combining sequencing and imaging, @sofiquinodoz maps the spatiotemporal dynamics of rRNA processing, demonstrating how rRNA serves as both a scaffold and a substrate for the nucleolus—a multiphase, liquid-like structure. https://t.co/FcwCUUDM2N @brangwynnelab @omenndarlingbio

[Omenn-Darling Bioengineering Institute @omenndarlingbio]

Now on the Princeton Engineering and ODBI sites, a new mapping tool that allows researchers to peer deep into cells' inner compartments to watch and control ribosome assembly, shedding new light on the machinery responsible for making proteins.

[brangwynnelab @brangwynnelab]

Excited that our nucleolus mapping paper just came out today in Nature! Truly an amazing study from even more amazing due of @sofiquinodoz & @jiang_lifei w/ @LafontaineLab & Sebastian Klinge and other fantastic co-authors https://t.co/68W7vEHmps

[Sofi Quinodoz @sofiquinodoz]

@ShechnerLab @dschweppe1 @oligopain @shaoenong @berteroale Congrats Dave!! Super cool

[Sofi Quinodoz @sofiquinodoz]

@rawatravans Thanks so much!

[Sofi Quinodoz @sofiquinodoz]

Excited to share a new preprint!
(1)🔬The nucleolus is the most prominent nuclear condensate, with a fascinating multilayered liquid-like structure, and is the site of ribosome biogenesis. But how does this multiphase architecture form and function?
https://t.co/xKP9tGFFlQ

[Sofi Quinodoz @sofiquinodoz]

@DavidWSanders2 @SuperSciJew @DrJorine @danielswlee @mitchguttman @_prashantbhat Thanks David 😊

[Sofi Quinodoz @sofiquinodoz]

@CreminsLab Thanks so much Jenn! Definitely a big team effort 💪😊

[Lifei jiang @jiang_lifei]

It has been a wonderful journey uncovering the mysteries of the multiphase nucleolus🤯🤩! So lucky to drive this project together with amazing postdoc @sofiquinodoz @brangwynnelab, and awesome collaborators, utilizing genomics, imaging, engineered rDNA🧬, and modeling approaches.

[Sofi Quinodoz @sofiquinodoz]

@jiang_lifei @brangwynnelab 💪🤩👩‍🔬🧬🔬 dream team!

[Sofi Quinodoz @sofiquinodoz]

@LomvardasLab Thanks so much Stavros!!

[Sofi Quinodoz @sofiquinodoz]

@C_wang_stories Thank you!

[Sofi Quinodoz @sofiquinodoz]

@KiWookKim816 Thank you!

[Sofi Quinodoz @sofiquinodoz]

@KalliKappel Thanks so much Kalli! And congrats on your position at UCLA! 🤩

[Sofi Quinodoz @sofiquinodoz]

@daph_cabi Thank you!

[Sofi Quinodoz @sofiquinodoz]

@yodai_takei Thank you Yodai :)!

[Sofi Quinodoz @sofiquinodoz]

@SuYapeng Thanks so much Yapeng!

[Sofi Quinodoz @sofiquinodoz]

@shrinivaslab Thanks Krishna :) !!

[Sofi Quinodoz @sofiquinodoz]

Also thanks to @SuperSciJew @DrJorine @danielswlee for initial inspiration/discussions for 5eU imaging to measure rRNA flux, and @mitchguttman @_prashantbhat for initial advice/protocols with 5eU-seq 🙏! Along with many others who helped with this work along the way!!

[Sofi Quinodoz @sofiquinodoz]

(12) Together, we find that different rRNA processing steps are not only spatially organized in distinct nucleolar phases, but also play an active role in building and arranging the nucleolar phases that serve as processing compartments.