A long sought after hypothesis has been that organizing biomolecules in and around nuclear bodies is essential for functional RNA processing. We now provide direct evidence of this in @Nature for nuclear speckles and mRNA splicing. Check out this thread!
https://t.co/DoXSB7SINt
What are the functional roles of 3D genome organization? Our paper in @Nature led by @_prashantbhat demonstrates how dynamic 3D genome organization around nuclear speckles plays a crucial role in regulating mRNA splicing efficiency. https://t.co/8KwfJHQWTt
4/2015: First day visiting Caltech
4/2026: Same spot, last day in Pasadena 11 years later!
Kudos to my mom for remembering this picture and wanting to recreate it. Moms know best :)
Also, she wants you to know she didn't age.
@uclacaltechmstp@Caltech@CaltechBBE
I matched to my #1 program at @UCSFPath in their Clinical Pathology/Physician Scientist Program!
Excited to meet my co-residents & colleagues! Kudos to @uclacaltechmstp, @mitchguttman, Zhen Mei, Dave Dawson and many others at @UCLA_Pathology for their support!
SF, here I come!
Many proteins bind RNA, yet we still don’t know what RNAs most bind because methods map one RBP at a time. In @CellCellPress, with the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. https://t.co/Zs2Rn35D3s
Excited that our nucleolus mapping paper just came out today in Nature! Truly an amazing study from even more amazing due of @sofiquinodoz & @jiang_lifei w/ @LafontaineLab & Sebastian Klinge and other fantastic co-authors https://t.co/68W7vEHmps
Excited to share our new paper out in @Nature revealing cell-type specific nuclear organization and its link to gene regulation using new spatial multi-omics technologies! https://t.co/0LC2GlEpQs
Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in @NatureGenet describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment.
https://t.co/0aINMj2MTu
Hi! I’ll be speaking at @harvardmed Department of Biomedical Informatics on December 5th about genome organization and splicing/speckles. Thank you to the organizers for the invite! Harvard/MIT/affiliate trainees can RSVP to attend with this link:
https://t.co/crLBGqb5Zf