Miguel Ramalho-Santos Lab

The Miguel Ramalho-Santos Lab does research on Developmental Epigenetics at the Lunenfeld-Tanenbaum Research Institute and the University of Toronto, Canada.

[Miguel Ramalho-Santos Lab @MRSantosLab]

Learn more about the lab's research and news at:
https://t.co/JBDoaj85bn
and
https://t.co/rlNYMz8N8C

[Miguel Ramalho-Santos Lab @MRSantosLab]

The #LTRI in Toronto is a diverse + and inclusive community in a multicultural city: we encourage candidates from underrepresented groups to apply! 2 PI positions, by Oct 20.
#womeninscience
#BlackandSTEM
#NativeinSTEM
#NativeScience
#LatinXinSTEM
#MarginSci
#DiversityinSTEM
👇

[Sinai Health @SinaiHealth]

Job Alert 🚨
We are looking for outstanding candidates to join our institute!
Find out more & apply:
Biomedical Discovery ➡️ https://t.co/HOjgJmHio7
Population Health Data Science ➡️ https://t.co/qBl4JkKXcf

[Miguel Ramalho-Santos Lab @MRSantosLab]

🚨 JOB ALERT 🚨
We are hiring TWO principal investigators in systems, cellular, chemical or molecular biology in Toronto, Canada at @SinaiHealth. We provide a generous startup, fully funded salary and academic appointment at U of Toronto.
Apply now or repost!

[Sinai Health @SinaiHealth]

Job Alert 🚨
We are looking for outstanding candidates to join our institute!
Find out more & apply:
Biomedical Discovery ➡️ https://t.co/HOjgJmHio7
Population Health Data Science ➡️ https://t.co/qBl4JkKXcf

[Miguel Ramalho-Santos Lab @MRSantosLab]

@DanielHermes1 @generegulation Updated link as below: https://t.co/5bH8PV8TNL

[Miguel Ramalho-Santos Lab @MRSantosLab]

Ending 2024 in style! We found that LINE1s are key “architects” of the nucleolar genome in human embryonic stem cells. This work brings together 2 facets of Barbara McClintock’s pioneering work: nucleolar organizer regions and transposable elements. https://t.co/2mZaMPtNuQ...

[Miguel Ramalho-Santos Lab @MRSantosLab]

Also noted: Ribosomal DNA copy number is associated with body mass in humans and other mammals. https://t.co/D5PmTst3D2

[Miguel Ramalho-Santos Lab @MRSantosLab]

Discussed in @MRSantosLab
lit review: Stem cell activity-coupled suppression of endogenous retrovirus governs adult tissue regeneration: Cell https://t.co/FGmgLn74q4

[Miguel Ramalho-Santos Lab @MRSantosLab]

Happy Halloween!

[Sinai Health @SinaiHealth]

In a groundbreaking discovery, Sinai Health researchers have found that transposable DNA elements – long considered “junk DNA” because they had no known function – are critical for early human development.

Congrats to Dr. Ramalho-Santos & team at LTRI!

https://t.co/H36s7fcy0y

[Miguel Ramalho-Santos Lab @MRSantosLab]

@Dev_Cell Highlights:
-Knockdown of LINE1 RNA induces reversion of naive hESCs to 8C-like cells
-LINE1 RNA and PRC2 maintain nucleolar architecture in hESCs
-Disruptions of the nucleolus de-repress the 8C program
-Chr19 is enriched for 8C genes and dissociates from the nucleolus in 8CLCs

[Miguel Ramalho-Santos Lab @MRSantosLab]

📢@MRSantosLab - LINE1 RNA prevents developmental reversion of human embryonic stem cells to the 8 cell-like state! + new insights on PRC2, nucleolus and chr. 19. Revised and expanded now @Dev_Cell, free access until Dec 4th (earlier version on bioRxiv):
https://t.co/tdVo5Gj2Xo

[Miguel Ramalho-Santos Lab @MRSantosLab]

Excellent team effort driven by postdoc Juan Zhang @LesleyZ618, working with Lamisa Mizan @mizanlam and Kirti Mittal in our lab, and in collaboration with Miguel Esteban, @jeffwranalab and @michaelhoffman. Thanks to all!
Watch this space for an update in the next few months…

[Miguel Ramalho-Santos Lab @MRSantosLab]

📣Sharing the latest research from the @MRSantosLab, just released on bioRxiv! We found LINE1 RNA promotes nuclear compartmentalization to repress the 8-cell state in human embryonic stem cells.
https://t.co/uE06Xx3QcY

👇Key findings:

[Miguel Ramalho-Santos Lab @MRSantosLab]

The results point to a conserved role for LINE1 in repression of developmental reversion in both mouse (@MPercharde et al, Cell 2018) and human. The findings raise fascinating questions regarding transposon evolution and their role in genome compartmentalization.

[Miguel Ramalho-Santos Lab @MRSantosLab]

Recent review from @MRSantosLab. Everything you wanted to know about hypertranscription but were afraid to ask! This review discusses concepts of hypertranscription & technological advancements to probe global transcriptional shifts in stem cell biology. https://t.co/cvFS4AHWSY

[Miguel Ramalho-Santos Lab @MRSantosLab]

Postdoc positions in the @MRSantosLab! Please RT. Upcoming departure of several very successful lab members + new funding = postdoc positions! Exciting new avenues in mouse development, hypertranscription, dormancy and environment-epigenome interactions.
https://t.co/1vyyptbUSb