Variant76

[Variant76 @MuffintopMogul]

@BB_Updates Worst BB ever

[Variant76 @MuffintopMogul]

@BB_Updates These people are idiots should have kept Jason they are going down one by one

[Variant76 @MuffintopMogul]

@realalexlains Parabéns! 🇺🇸🇵🇹

[Variant76 @MuffintopMogul]

Hey @FOXSoccer we don’t care about what “celebrities” are at the soccer game. Just let us watch the GAME

[Dr. Lynn Fynn-derella (ret) 🐭 @Fynnderella1]

Though NO ONE here will need this, here's the comprehensive picture on **repurposed drugs and antihistamines for hantavirus**, based on what's actually in the scientific literature:
DRUG REPURPOSING STUDIES ON HANTAVIRUS**

**1. Major Drug Repurposing Screen (March 2026)**

**Study:** "Drug repurposing high-throughput screen identifies candidate antiviral compounds against Puumala Orthohantavirus"  
Published in bioRxiv (preprint), March 2026 [biorxiv](https://t.co/Q2x0WemyQI)

**Key findings:**
- Tested **annotated drug space** (repurposable drugs) in A549 lung cells and HUVECs (human endothelial cells)
- Screened live **Puumala virus (PUUV)** — a European hantavirus causing HFRS
- **Identified 70 drugs with antiviral activity** across both cell systems
- Validated across two different cell types (more reliable than single-cell studies)

**7 drugs/compound classes identified:**

| Class | Specific Examples | Mechanism |
|-------|------------------|-----------|
| **Heat shock protein inhibitors** | — | Block infection via HSP pathway |
| **mTOR pathway inhibitors** | — | Block host pathway needed for viral infection |
| **Nucleotide synthesis inhibitors** | — | Deplete building blocks virus needs |
| **Certain antibiotics** | (specific ones not named in snippets) | New avenue unexplored for hantavirus |

This is a **systematic drug repurposing map** — the first large-scale screen specifically for hantavirus host-directed drugs. [biorxiv](https://t.co/Q2x0WemyQI)

***

**2. Entry Inhibitors Identified (2021)**

**Study:** "Identification of Novel Antiviral Compounds Targeting Entry" (PubMed ID: 33923413) [pubmed.ncbi.nlm.nih](https://t.co/sXM3NFw0fB)

**Hantaviruses tested:**
- **Hantaan virus (HTNV)** — Old World hantavirus
- **Andes virus (ANDV)** — New World hantavirus (most deadly in Americas)

**Key findings:**
- Screened compounds against pseudoviruses for HTNV and ANDV
- **Validated with infectious HTNV in BSL-3 lab** (high-containment facility for dangerous viruses)
- Two hits strongly validated:

| Compound | Mechanism |
|----------|-----------|
| **Emetine dihydrochloride** | Protein synthesis inhibitor, blocks viral entry |
| **Tetrandrine** | Calcium channel blocker, blocks entry |

Both are **old repurposed drugs** with established safety data. This study genuinely identified **entry inhibitors** that work against dangerous hantavirus strains. [pubmed.ncbi.nlm.nih](https://t.co/sXM3NFw0fB)

***

**CURRENTLY USED OR STUDIED REPURPOSED DRUGS FOR HANTAVIRUS**

**1. Ribavirin** (Antiviral nucleoside analog)

**Evidence status:**
- ✓ **Shown effective for HFRS** (Old World strains: Hantaan virus) in randomized controlled trials [healthline](https://t.co/YsUL27OSG5)
  - CDC 2004 trial: 242 HFRS patients
  - Reduced mortality, peak creatinine, duration of oliguria
- ✗ **Not effective for HPS** (New World strains: Sin Nombre, Andes virus causing cardiopulmonary syndrome) [hantacount](https://t.co/NUQaXAeERl)
  - 2004 RCT showed insufficient efficacy and safety issues
  - Retrospective analysis of American Southwest HPS cases: no significant difference between treated/untreated groups
- ✓ **May help if given VERY early** (febrile prodrome, before pulmonary symptoms) [healthline](https://t.co/YsUL27OSG5)
  - Animal study (2021): ribavirin + favipiravir worked against Hantaan virus
- ✗ **No benefit once respiratory failure begins** — damage becomes inflammatory rather than viral [hantacount](https://t.co/NUQaXAeERl)

**Use:** Some South American centers still use iv ribavirin empirically for early HPS, but evidence is weak. [hantacount](https://t.co/NUQaXAeERl)

***

**2. Favipiravir** (RNA polymerase inhibitor)

**Evidence:**
- 2021 animal study: **ribavirin + favipiravir** combined showed positive results against Hantaan virus [healthline](https://t.co/YsUL27OSG5)
- Favipiravir is a repurposed influenza antiviral now used for COVID-19 in some countries

[Variant76 @MuffintopMogul]

@WilkowMajority check section 50310 of the California billionaire tax allows the legislature to tweak the law with two-thirds vote. So looks like the added a way to get everyone after it is passed

[Tony Kinnett @TheTonus]

BREAKING: Black smoke signals that the College of Mullahs has not reached a decision on the new Ayatollah today.

[Variant76 @MuffintopMogul]

@TheTonus @DailySignal This wins the best x post of the day🤣🤣

[Elon Musk @elonmusk]

Think in probabilities

[Variant76 @MuffintopMogul]

@unusual_whales Not a surprise Eric Adam’s told everyone it would happen in 2023

https://t.co/lFPj5U0Gkh

[Variant76 @MuffintopMogul]

@TheInsiderPaper Ya and using American tax payer dollars to do it with most likely

[Leading Report @LeadingReport]

BREAKING: Trump admin is looking into normalizing portable mortgages, allowing Americans to keep their interest rate, term and lender when moving to a different home.

[Variant76 @MuffintopMogul]

@WorldDarkWeb She didn’t want a divorce she wanted her husband to beg for her to stay so she could humiliate him and he said not today bitty 🤣

[Variant76 @MuffintopMogul]

@usanewshq Yes 100% and I have parents who hold dual citizenship

[Variant76 @MuffintopMogul]

@newtgingrich https://t.co/8N8RSFPhM8

This is about the UK but is becoming increasingly relevant here in the US

[David | Fink | Markets Talk, We Translate @Fink_Money]

How the UK traps the middle class.

Important watch!

[Variant76 @MuffintopMogul]

@NYGovPress Texas mandates all law enforcement agencies report to NIBRS since September twenty twenty-three-over one thousand agencies submit monthly, making their data pretty complete and detailed. New York only about twenty-five percent of its five hundred eighty-three agencies report

[Variant76 @MuffintopMogul]

@phpfyi @MmeHuckleberry @mtgreenee Are you mental!! There isn’t a single country on this planet where medical professionals work for free! They are paid by the government who tax the shit out of the people to pay for it.

[Variant76 @MuffintopMogul]

Happy Birthday America

[Variant76 @MuffintopMogul]

@unusual_whales And just like that it’s back

[Defiant L’s @DefiantLs]

Crazy to think about…