Matthew Murphy

Life science consulting. @nyulangone PhD, @Cornell alum. Baseball, wine, biology, and Jesus, not in that order. Tweets are my own personal opinion.

[Matthew Murphy @MurphyBiotech]

@bradloncar No, NOW you’ve experienced what it’s like to be a Knicks fan

[Matthew Murphy @MurphyBiotech]

Up at 5:20am to fly from BOS > Chicago and got to #AACR25 just in time for the opening plenary session!

[Matthew Murphy @MurphyBiotech]

@Mykalt45 @BowTiedBiotech What are your thoughts on combining 2 MOAs in a single dual-payload ADC vs just combining two separate products. Makes sense if second payload also has systemic tox, but if it’s manageable like PARPi why not give yourself room to optimize each dose separately?

[Matthew Murphy @MurphyBiotech]

@bradloncar Could be partly due to the approach as well, no? (i.e., higher costs of viral manufacturing vs. gene editing using non-viral delivery)

[Matthew Murphy @MurphyBiotech]

Exciting milestone for the gene editing field — just the beginning!

[U.S. FDA @US_FDA]

Today we approved two milestone treatments - the first cell-based gene therapies to treat sickle cell disease in patients 12 years and older. https://t.co/az8lDdRyz0

[Matthew Murphy @MurphyBiotech]

@zhaoweiasu Do we know that viral integration is actually the driver of secondary malignancy here? Or is it possible some of the cells that are transduced (and CAR+) happen to carry mutations that increase risk of secondary malignancy (and these may be enriched during ex vivo expansion)?

[Matthew Murphy @MurphyBiotech]

Happy opening day! #stlcards #nooooooooot

[Matthew Murphy @MurphyBiotech]

@Mykalt45 In vivo HSC targeting certainly has some attractive gene editing applications. Will be interesting to see how they fare in the in vivo CAR space going after HSCs while most others are directly targeting T cells. Haven't seen much public data from them yet though

[Matthew Murphy @MurphyBiotech]

@BowTiedBiotech @Mykalt45 Cancer applications will be tricky given that hypomethylation is primarily anti-cancer but can be pro-tumor in some contexts. And possible that by the time you have cancer Dx you’re past the point where modulating HM matters. Slower progressing diseases could be a better fit?

[Matthew Murphy @MurphyBiotech]

@dgoold Any tips on where a Cardinals fan who will be in Jupiter next week for what was supposed to be spring training can see some of the players practice?

[Jonathan Tjarks @JonathanTjarks]

Does My Son Know You? https://t.co/37lKB9pGgJ via @ringer

[Matthew Murphy @MurphyBiotech]

This was interesting but a bit overwhelming tbh — Daily Quordle #19
4️⃣6️⃣
7️⃣9️⃣
https://t.co/e2yDkRM6Ol

[Matthew Murphy @MurphyBiotech]

Am I doing this right?
Wordle 203 5/6

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🟩🟩🟩🟩🟩

[Matthew Murphy @MurphyBiotech]

Multiple effective oral small molecule antivirals, in record time, and with different MOAs which may be amenable to combination -- great news for the fight against COVID (especially on a global scale given ease of manufacturing)

[Norm Macdonald @normmacdonald]

Scripture. Faith. Grace. Christ, Glory of God. Smart man says nothing is a miracle. I say everything is.

[Michael Gilman @michael_gilman]

This is why we have the internet.

[Matthew Murphy @MurphyBiotech]

Wow — @zjanewkirk putting in work! #legend #Jeopardy

[Matthew Murphy @MurphyBiotech]

Fascinating example of what we can learn about virus transmission when cases are rare and strong contact tracing programs are in place -- and highlights an important point that while avoiding "close contact" can reduce transmission risk, it doesn't confer complete protection

[Los Angeles Times @latimes]

A South Korean study raises concerns that six feet of social distance may not be far enough to keep people safe from the coronavirus.

https://t.co/V12iHkm3Ft

[Matthew Murphy @MurphyBiotech]

Important reminder for everyone in Massachusetts -- new COVID measures go in place midnight tonight, including requirement to wear masks in public spaces regardless of whether you are within 6 feet of anyone else

[Charlie Baker @MAGovArchive]

Today we are taking several targeted measures to curb rising #COVID19MA cases + hospitalizations.

Our goal is to disrupt this trend now, so the Commonwealth can keep our economy + schools open and prevent the need to roll back to Phase I or II.

➡️ MORE: https://t.co/FCUWR035Vf