@Dr_SwatiNehete@Nature The data on aspirin and other anticoagulants during and after Covid are very mixed and it’s not very clear cut that this will provide across-the-board benefit.
Clotting isn’t specific to #COVID, it’s just more profound & longer lasting w this 🦠
I’ve been shocked in COVID by my patients clotting on full heparin drips.
In🧵👇I give examples & discuss data - it can happen w bacteria, but the pathology persists in #LongCOVID
5/ Let’s pose some Important Questions:
✔️Are these findings COVID-specific?
✔️How long do these genetic/cell function changes last?
✔️Do they contribute to #LongCOVID?
✔️What’s the cost of repeat infections?
4/ Monocytes of COVID pts display abnormal markers of inflammation & clotting that drives us to immuno-thrombosis & vascular platelet+cell aggregates.
Very scary stuff if you want a body & brain to get blood, food & oxygen normally.
I highlighted excellent discussion points👇
3/ Taking blood from 2 UK SARS CoV2 studies…
📍They compared COVID🩸(N=62 mild/mod dz) to normal controls
📍Then conducted genetic, metabolic & functional assays
👀 Look how different gene expression was (color difference) in COVID vs. HC (healthy control) pts
What’s it mean?
2/ These data explain how the COVID virus places our bodies at risk for macro (large) blood clots in acute dz (which we see often), brain disease due to down-stream micro-clotting, and possibly later cardiovascular dz.
What did these London investigators find?
1/🧵 Our cell’s genes are rewired in MILD COVID 🧬
Stunning data in @Nature
White Cells (monocytes) switch gene expression from an established innate immune profile to a pro-clotting signature in COVID.
We’re immunocompromised.
Let’s unpack this…
https://t.co/3kByQdnJPM
“Yesterday I was stripped of my board certifications in Internal Medicine and Cardiology after decades of perfect clinical performance, board scores, and hundreds of peer reviewed publications. None of this will stop until there is a "needle in every arm." https://t.co/Fm85L7xsG4