The description of the clinical profiles of pediatric-onset non-mastocytosis Mast Cell Activation disorders (#MCAD) may help to avoid diagnostic delay.
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#pai_journal#originalarticle#openaccess#hereditaryalphatryptasemia #KITmutation #mastcell #mastcellactivationsyndrome #tryptase #mastcellactivation
This study was a prospective, longitudinal cohort embedded within the Hong Kong Drug Allergy Delabelling Initiative. Adults referred for suspected penicillin allergy underwent standardized evaluation including skin test and drug provocation test. https://t.co/KwqDuuc6bL
#COVID history may increase the risk of developing #allergic#conditions like #asthma and #dermatitis, with significant findings across age groups. Clinicians should monitor for new #allergies up to 18 months post-infection. https://t.co/tsLtwis8Gt
Free Access: Protein Glycosylation: An Emerging Regulator of Allergic Diseases. Pan Li, Xianghong Wang, Ming Zeng, Zheng Liu
With over 140 references, this review article provides an overview of the role of glycosylation in type 2 inflammation, associated allergic diseases, and therapeutic implications. It includes a discussion on the glycosylation of key proteins involved in Th2 inflammation, including cytokines and their receptors, IgE, FcεRI, IgG, mucins, STAT6, cytotoxic T-lymphocyte-associated protein 4 (CTLA-4).
📢A translational approach to improve therapeutics in #AtopicDermatitis and beyond [Liu D, Patel D, Lau M, Largen J, Hu BD, He H, Guttman-Yassky E. J Immunol. 2025 Sep 1;214(9):2165-2179] @EmmaGuttman
👏https://t.co/55M9BSoqK5
📢#DrugAllergy Risk Stratification in Children With Immediate or Delayed Urticaria During Antibiotic Treatment [Mori F et al. Clin Exp Allergy. 2025 Nov 20. doi: 10.1111/cea.70181] @ClinExpAllergy@lenehgarvey 👏 https://t.co/FDJX9CNGj6
#Bradykinin-Mediated #Angioedema [The publication of this infographic was funded by Pharvaris and is based on a Pharvaris-sponsored symposium that took place on the 29th May 2025, in Budapest, Hungary. EMJ. 2025] Link: https://t.co/cxOv0zFf7B
#Unlabelled#Allergens Linked to Rising #Anaphylaxis Risk: analysis from the French Allergy-Vigilance Network has identified eight food allergens not currently covered by mandatory European labelling, yet frequently implicated in food-induced anaphylaxis. https://t.co/8GIYt8TTKi
#Foodallergies are a growing global health concern with symptoms ranging from mild to severe cases leading to anaphylaxis. Avoidance of foods containing the triggering allergen is typically recommended but may cause nutritional deficiencies if the patient is not following a personalized diet plan.
In this issue, Spolidoro et al., in their systematic review and meta-analysis, present the prevalence estimates for specific tree nut allergy/sensitization, including hazelnut, walnut, almond, Brazil nut, cashew nut, pistachio, chestnut, pecan nut, and pine nut based on data published between 2000 and 2021. A systematic review and meta-analysis by Riggioni et al., assesses the accuracy of diagnostic tests for IgE-mediated food allergy. Roth-Walter et al. discuss the opposing nutritional demands of regulatory and inflammatory cells with a focus on inflammation-linked nutrients such as iron, vitamins A, B, C, and other antioxidants. Okubo et al. identify wheeze trajectory in early childhood using group-based trajectory modelling in a nationwide representative birth cohort of Japanese mother–child pairs and examine the association between periconceptional maternal diet quality and wheeze trajectories. Radulovic, Foong, Bartha, Marques-Mejias and Krawiec et al. show that the basophil activation test is an effective tool for identifying patients at risk of developing severe symptoms to a small amount of baked egg. Immormino et al. use a mouse model to investigate whether particulate matter promotes sensitization to environmental exposure to peanuts and the development of peanut allergy. Castaño et al. show that the combination of avidin and CD63 enhances the identification of activated basophils and improves the classification accuracy of peanut allergy. Ferslew et al. evaluate the safety, tolerability, and immunogenicity of a peanut DNA vaccine, ASP0892, in adult and adolescent patients with peanut allergy in two phase 1 studies. Issa et al., using a mouse model, assess the effect of chronic perinatal exposure to a common food additive, titanium dioxide, on intestinal homeostasis and predisposition to food allergy. Voskamp et al. evaluate safety and tolerability of a peptide immunotherapy, PVX108, in peanut-allergic individuals. Landau et al. postulate that predictive modeling using routinely collected electronic medical record data can serve as a powerful tool to stratify an infant's risk of developing food allergy. He et al. demonstrate that β-1,3-glucan may exacerbate the development of food allergy, and act as a mucosal adjuvant increasing IgA levels.
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#MustRead Thymic Stromal Lymphopoietin #TSLP, Its Isoforms & the Interplay with the Epithelium in #Allergy and #Asthma [Smolinska S, Antolín-Amérigo D, Popescu FD, Jutel M. Int J Mol Sci. 2023 Aug; 24(16):12725. doi: 10.3390/ijms241612725] @DarioAntolin
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BSACI Guideline for the diagnosis and management of Pollen Food Syndrome/Oral Allergy Syndrome: MGP has produced a summary of the guideline which was recently published in CEA. Find out more at https://t.co/xxUtDPklWm
📢#MustRetweet: 2022 update of the Global Strategy for Asthma Management and Prevention!
📢#MustVisit ➡️https://t.co/svDRpBM2Kn
📢#MustRead: #GINA Main Report with Tracked changes➡️https://t.co/MCdrzLiHlq
📢#MustFolllow ➡️@ginasthma 👏👏👏
The virome refers to the collection of all viruses that reside in the human body and make up a large part of the human microbiome. An Editors’ Choice study reports that lung viromes may offer biomarkers of asthma disease progression. https://t.co/kImwzaF0bp
Introducing the October cover: this month's theme is Janus Kinase (JAK) Inhibitors. The Editors are grateful to Dr. Richard J. Looney for his assistance as Guest Editor of this issue.