Nestor Ospino

Cardiólogo Intervencionista, Medico lnternista. Formado en @hospitalclinic Barcelona, Catalunya. Tanatopraxia.

[Nestor Ospino @NEOR72]

@CarlosME67 @AlertaMundoNews Diagnostico: oligofrenico

[Nestor Ospino @NEOR72]

@Oscar010188 @ojocolombia2026 @petrogustavo Le regalo el diagnóstico, ud es oligofrenico tío.

[Davide Capodanno @DFCapodanno]

All the explanations I’ve heard today for the negative CLOSURE-AF result—some so strained they’re almost impressive.

1) The devices were “outdated” and therefore responsible for excess complications (the usual argument that things only go wrong elsewhere).
2) DAPT was used after LAAO, which is now said to be obsolete because of bleeding concerns compared with DOAC-based strategies (a claim that is often repeated, less often demonstrated).
3) Stroke rates were similar, so the signal is attributed mainly to bleeding and procedural issues—as if that were a minor point.
4) The composite endpoint is criticized for mixing different mechanisms, although if anything it should have favored non-inferiority.
5) The early phase of enrollment is invoked to argue that complications are not representative of current practice (again, complications seem to belong to others).
6) And then there are the usual remarks about loss to follow-up, crossovers, and lack of blinding.

What seems to be missed in this accumulation of arguments is straightforward: the burden of proof lies with LAAO, not with the control arm. The issue is the strength of the evidence supporting LAAO, not medical therapy, which remains the reference standard.

[Nestor Ospino @NEOR72]

@rodri_2310 @mauriciopedroza 🤭

[Davide Capodanno @DFCapodanno]

Finally published: the COBRRA trial, the first randomized head-to-head comparison of major DOACs — something the companies would never have done themselves, as a direct confrontation goes beyond their commercial interests. This was driven by independent investigators. The results somewhat support the idea of apixaban being the “safer” DOAC. That said, the list of study limitations is long, and for me, labeling something as “safe” is not enough — after all, even placebo is “safe” when it comes to bleeding. https://t.co/eYehndGzvB

[Nestor Ospino @NEOR72]

@intermilanoXI @FerAlvarez Las estadísticas no mienten. Dominicana es superior. No aceptarlo es oligofrenico.

[Nestor Ospino @NEOR72]

@FerAlvarez Mis respetos y admiración por tu objetividad. Venezuela podrá ganarle un partido de fútbol a Colombia pero jamás ha sido superior a mi sele. Igual en béisbol Venezuela es muy superior a Colombia pero no a Dominicana. Las estadísticas de jugador por jugador no tienen discusión.

[Nestor Ospino @NEOR72]

@extinguiendonos Se parece al q le hicimos la autopsia la semana pasada 😕

[Nestor Ospino @NEOR72]

@InesBetancur1 Se quedó corto el poli. Al de la moto lo espero en urgencias 🤭

[Nestor Ospino @NEOR72]

@MryRodrguez4 Los humanos.

[FC Barcelona @FCBarcelona]

HUGEEEEE WIN!!!

[Nestor Ospino @NEOR72]

@iingridrod Error de el. Cómo vas a salir con alguien con tan pocas aspiraciones en la vida. Ser Tik toker 🤨

[Nestor Ospino @NEOR72]

@nemotap777 @QuePocaMadre_Mx cosillas de tercer mundistas.

[Nestor Ospino @NEOR72]

@EsTendenciaEnX Está pidiendo ir a la mesa de disección

[Nestor Ospino @NEOR72]

@FerAlvarez 💪

[Nestor Ospino @NEOR72]

@EsTendenciaEnX Envíenme el cadaver. Un espécimen digno de estudiar presencia de Parenquima cerebral

[Nestor Ospino @NEOR72]

@FerAlvarez La más equilibrada de todas las series

[Nestor Ospino @NEOR72]

@RaulReyko @Dios_0ficial Divina mujer

[Nestor Ospino @NEOR72]

@GuillermoCelis 💪💪💪💪

[Nestor Ospino @NEOR72]

@FerAlvarez 💪💪💪💪