N John Adams

Patient advocate & mgt consultant.

[N John Adams @NJohnAdams12]

https://t.co/eOLy5fyWWG

[N John Adams @NJohnAdams12]

https://t.co/vOdSV4DEBh

[Afshine Emrani MD FACC @afshineemrani]

I'm a cardiologist. For months I've been telling you that inflammation is the fire behind heart disease — not just cholesterol. That we've been treating the smoke while the fire kept burning.

Penn Medicine just built the fire extinguisher.

They took the most powerful immune technology in cancer medicine — CAR T-cell therapy — and flipped it. Instead of engineering killer cells to destroy tumors, they engineered regulatory T cells to suppress the chronic arterial inflammation that causes heart attacks.
Published in Circulation. The results stopped me cold.
In CAR T cancer therapy, doctors extract your T cells, genetically engineer them to recognize a specific target, and infuse them back into your body as precision-guided missiles. It has cured previously terminal blood cancers. The technology won its developers a Nobel Prize.

The Penn team asked a question no one had asked before: what if we aimed this at the arteries?
They engineered regulatory T cells — Tregs, the immune cells whose job is to calm inflammation rather than cause it — to specifically target oxidized LDL. OxLDL is the molecule that starts the entire atherosclerotic cascade. It infiltrates your artery wall, triggers macrophages to gorge on it and become foam cells, releases inflammatory cytokines, recruits more immune cells, and builds the plaque that eventually ruptures and causes a heart attack.

OxLDL is the match that lights the fire. These engineered CAR Tregs are designed to find that match and snuff it out — at the arterial wall itself.

The results in mouse models of atherosclerosis:
Blocked macrophage foam cell formation — the cellular process that builds plaque. Dramatically reduced arterial wall inflammation. Prevented over 70% of plaque buildup compared to untreated controls. And critically — preserved normal immune function everywhere else.

That last point is essential. Previous anti-inflammatory approaches to atherosclerosis failed because they suppressed the entire immune system — leaving patients vulnerable to infections and other complications. Colchicine works modestly. Canakinumab in the CANTOS trial reduced events but increased fatal infections. The immune system is a sledgehammer. You can't just turn it down globally.
CAR Tregs solve this by being targeted. They don't suppress your whole immune system. They patrol your arteries specifically, calming the inflammation at the exact site where it's causing damage — and leaving the rest of your immunity intact.

One infusion. Targeted. Precise. The cells do the work.
Lead author Robert Schwab of Penn Medicine put it directly: "If we can get the immune system to see OxLDL and provoke an anti-inflammatory response, it would reduce inflammation and essentially stop the pathogenesis in its tracks."

Senior author Avery Posey: "Our study shows for the first time how CAR T cell technology could be used to treat the underlying cause of the most common form of heart disease — the leading cause of death worldwide."
As a cardiologist who has spent twenty years treating the downstream consequences of arterial inflammation — the stents, the bypasses, the cardiac rehab, the second heart attacks — I need you to understand what this represents.

Every treatment I currently have manages the damage after the fire has burned. Statins lower the fuel supply. Blood pressure meds reduce the mechanical stress. Stents prop open arteries that have already narrowed. These save lives. I use them daily.
But none of them put out the fire itself.
CAR Tregs are engineered to extinguish the inflammation at its source — inside the artery wall — before the plaque builds, before the vessel narrows, before the rupture, before the heart attack.
This is the shift from managing disease to correcting the biological process that causes it. At the cellular level. With living medicine.

This was demonstrated in mice, not humans. The leap from mouse models to human cardiovascular trials is enormous and filled with failures. Manufacturing CAR T cells is currently expensive — roughly $400,000 per treatment in cancer. Scaling this for a disease that affects billions would require a manufacturing revolution. Long-term safety of engineered immune cells patrolling human arteries for years or decades is completely unknown. Human trials are likely years away.
But 70% plaque reduction. With preserved immune function. Targeting the exact inflammatory mechanism I've been writing about for months. Published in Circulation — the flagship journal of the American Heart Association.
The trajectory is unmistakable.
Gene editing to permanently lower cholesterol. Personalized mRNA vaccines to hunt cancer. GLP-1 drugs rewiring metabolism. Cellular reprogramming to reverse aging. And now — living immune cells engineered to extinguish the inflammation that causes the number one killer on earth.
Every one of these treats the root cause instead of managing the downstream damage. Every one of them was impossible a decade ago. Every one of them is in trials or approaching trials right now.
I've held dying hearts in my hands in the cath lab at 3 AM. Hearts that were destroyed by inflammation I could see but couldn't stop.
The day I can infuse a patient with cells engineered to stop that inflammation before it ever builds the plaque — that's the day cardiology changes forever.
We're not there yet. But the fire extinguisher just passed its first test.

[N John Adams @NJohnAdams12]

Loophole in Patent Law Brings ‘Miracle Drug’ to Patients Who Can’t Afford It https://t.co/0UEZUQGmvB via @NYTimes @picardonhealth

[Warren Kinsella @kinsellawarren]

My new book has received zero mentions on CBC, CTV, Globe, Star et al. Zero.

It's been a bestseller for two months and is now in its second printing, despite that.

Actually, not "despite that." *Because* of that, I now think.

[Rand Paul @RandPaul]

For years, I raised alarms about dangerous gain-of-function research being farmed out to foreign countries, and I was told it was a conspiracy theory. Now, declassified documents show that the U.S. funded over 120 biolabs across more than 30 countries. Some of this research was conducted overseas precisely because scientists knew it would face scrutiny on American soil.

I'm calling for a presidential commission of scientists to review all gain-of-function research going forward. We're going lab by lab and pathogen by pathogen until the American people know the full truth.

https://t.co/gtv6sZ7viR

[Afshine Emrani MD FACC @afshineemrani]

1/5
An open letter to @TheLancet from an Iranian-Jewish cardiologist.
Today, one of the world's most prestigious medical journals published a campaign to suspend the Israeli Medical Association from the World Medical Association — the body founded after WWII to ensure physicians would never again be weaponized by political ideology.
I'm a cardiologist. I'm an Iranian Jew who grew up under a regime where medicine was subjugated to the state.
What The Lancet just did is a disgrace to my profession.
Here's what they published — and what they deliberately left out.

[Open Source Intel @Osint613]

Bill Clinton: “I killed myself trying to give the Palestinians a state. I had a deal they turned down that would have given them all of Gaza and 97% of the West Bank. You name it. They turned it down.”

The Palestinians never wanted peace.

This must be shared every single day.

[N John Adams @NJohnAdams12]

Fruit and Vegetables Are Toxic to My Daughter, Says Mom of 4-Year-Old Girl ⁦@BMC_Patients⁩ @canpku ⁦@CBCNews⁩ https://t.co/hNVqRa6uSX

[Heather Exner-Pirot @ExnerPirot]

Facts:
1. TMX is a government asset whose costs are covered by tolls from O&G producers. It is profitable.
2. Oilsands are not the most expensive barrel anymore, because it’s not 2015. They are generally among the lowest break-even barrels in North America.
3. Oilsands are not the most carbon intensive barrels. They are only 1-3% higher emitting than the average US refinery barrel, and are lower emitting than heavy oil competitors Iraq, California and Venezuela.
Sources in thread /1

[Brian Lilley @brianlilley]

We need more of this.

[David Krayden @DavidKrayden]

Andrew Coyne on the spring economic statement and the Canada Strong sovereign "wealth" fund:

"If you subtract the CPP and the QPP, we have a debt to GDP ratio of only 10%. "Well, you can't actually use pension funds to pay off your debts. It's a completely bogus comparison.

"But this is the thing. It's the same complacency. It's the same very top-down government directed, state run pension investment funds and this kind of thing. There's really not any sort of new development."

[N John Adams @NJohnAdams12]

⁦@elonmusk⁩ https://t.co/T0kSHr4zS9

[Dr Alo, DO, FACC @MohammedAlo]

What is Lipoprotein a and what can we do about it?
https://t.co/s6munauXNK

[Heather Exner-Pirot @ExnerPirot]

A bit lost in the good news of the Enbridge $4B Sunrise expansion is that 36 nations got a 12.5% stake in Enbridge’s Westcoast natural gas pipeline system last year with the first federal Indigenous loan guarantee, to help pave the way for this.
It's good to be reminded that there are pathways for mutual benefit and we have good tools and willingness to find those, including in BC and including on pipelines.
There's Indigenous ownership in over 5000km of pipelines in Canada.
https://t.co/a0tzzzRRuj

[Eric Topol @EricTopol]

A harsh critique of the recent @cochranecollab meta-analysis of the anti-amyloid drugs for Alzheimer's disease
https://t.co/EU4JMOVWkV
'These results and their overarching conclusion that “successful removal of amyloid from the brain does not seem to be associated with clinically meaningful effects in people with mild cognitive impairment or mild dementia due to Alzheimer’s disease” are, however, fundamentally undermined by pooling agents with markedly different, and in some cases negligible, target engagement.'

[N John Adams @NJohnAdams12]

A.I. ‘Hallucinations’ Created Errors in Court Filing, Top Law Firm Says https://t.co/rmsX3k8ZnP via @NYTimes

[N John Adams @NJohnAdams12]

Source: Mexico News Daily https://t.co/QSgIaoZOxM

[David Frum @davidfrum]

mRNA vaccines = miracle drugs.