NMorais Lab

Disease Transcriptomics Lab, led by Nuno Barbosa-Morais, at @nova_medschool.
bsky:

[Biomics Twinning @BiomicsTwinning]

🧬 From Data to Discovery!

On 9 October, BIOMICS welcomed @emblebi experts to @GIMM_Institute for @uniprot training (15 participants), a Biomedical Data Science Seminar & a new @BiomicsTwinning Friends interview! 🎥

#BIOMICS #UniProt #Bioinformatics

[NMorais Lab @NMoraisLab]

@BiomicsTwinning @EMBO_YIP @embl @ItaiYanai @MartinJLercher He looks forward to not only bring creativity training to Portugal but also incorporate some of the concepts in his Critical Thinking teaching, which also covers Day Science.

[NMorais Lab @NMoraisLab]

Thanks to the support of @BiomicsTwinning and @EMBO_YIP, Nuno is now a Certified Night Science Trainer, after attending the wonderful “train the trainer” event at @EMBL Heidelberg last week, led by the two and only @ItaiYanai and @MartinJLercher.

[Itai Yanai @ItaiYanai]

This week we held our second-ever “train the trainer” event in Heidelberg at EMBO/EMBL to pass on our teachings on the creative scientific process to 50 instructors. We're on our way to achieving our mission of bringing creativity training to all scientists worldwide!

[NMorais Lab @NMoraisLab]

New preprint 📢! We analysed stress granule transcriptomes and found differential centrifugation is strongly biased by RNA length. Correcting for this erases most reported overlap. Mitochondrial RNAs remain as a modest signal, hinting at immune signalling. https://t.co/kQw0Hx8Ye0

[NMorais Lab @NMoraisLab]

When the PI’s away, the Lab will happily and productively play. 🙂

[NMorais Lab @NMoraisLab]

Farewell and welcome: Marta Bica 🇵🇹(PhD alumna, 2018–2026) moves to Botton-Champalimaud Pancreatic Cancer Centre as a single-cell/spatial transcriptomics expert, while Alessandro Minguzzi 🇮🇹joins today, becoming a PhD student in Sept, studying CDKN2A in cancer. #Alumni #PhD

[NMorais Lab @NMoraisLab]

(4/4)

Software can expose assumptions, but interpreting them is still on us. That scrutiny is what @BiomicsTwinning , our Horizon Europe project, aims to instil in the next generation of researchers.

Explore our tools 🧬https://t.co/orGVYB3le4
#OpenScience #CriticalThinking

[NMorais Lab @NMoraisLab]

Garbage In, Plot Out 🧠
A bioinformatics pipeline will always give you something: a plot, a p-value, a cluster. It won’t tell you whether the parameters you chose were the right ones. That’s the black box problem in bioinformatics📊.
A thread on why critical thinking matters 🧵

[NMorais Lab @NMoraisLab]

(3/4)
Same story in alternative splicing. A gene either “looks” differentially spliced or it doesn’t, depending on the threshold you pick. betAS models each PSI estimate with a beta distribution, so the uncertainty behind it is visible.

[NMorais Lab @NMoraisLab]

🚀 Our new research lab website is now live!
After a few months of moving, settling in, and rebuilding, the Disease Transcriptomics Lab is now online:
https://t.co/JzcYcqyvML
Find out more about our research, tools, people, ethos, and opportunities to join us.

[Rafael Irizarry @rafalab]

Congratulations to the R Core Team on receiving the 2026 Rousseeuw Prize for Statistics. For over 30 years, R Core has maintained one of the most important pieces of infrastructure in statistics. Little recognition, thousands of volunteer hours, and enormous impact. Thank you!

[NOVA Medical School, Faculdade de Ciências Médicas @nova_medschool]

NOVA Biomedical Research (NBR) is a program for those who want to discover, question, and advance science.

1/4

[NMorais Lab @NMoraisLab]

Finally out, a much improved peer-reviewed article published in NAR Genomics & Bioinformatics @OUPAcademic.
👏 @ritamtbs and @AKaizeler!
https://t.co/eZPIq97WOL

[NMorais Lab @NMoraisLab]

Following the @Bioconductor package, the
@biorxivpreprint preprint: "Exploring molecular signatures of senescence with markeR, an R toolkit for evaluating gene sets as phenotypic markers". 💻🧬📰
👏 @ritamtbs 💪
https://t.co/e8jR3kv0Ie

[Biomics Twinning @BiomicsTwinning]

🎥 NEW Getting to know BIOMICS Members episode!
Meet @mirimiam from @CRGenomica, sharing his scientific journey, perspectives on collaboration, and research in evolutionary medical genomics.
📺 https://t.co/fH0hqivHUf

#BIOMICS #HorizonEurope #Genomics #BiomedicalScience

[Biomics Twinning @BiomicsTwinning]

🚀 Today’s #BIOMICS course at @GIMM_Institute: A packed room exploring probabilistic #model #building, #Bayesian thinking, #AI, diffusion models, and active learning 🧠
Fantastic discussions and engagement throughout the day!
#BIOMICS #DataScience #MachineLearning #HorizonEurope

[Biomics Twinning @BiomicsTwinning]

🚨 Now at
@GIMM_Institute, Mafalda Dias & Jonathan Frazer, from @CRGenomica talking about how we can read #evolutionary constraints with #deep #learning.

#EUfunded #BIOMICS #EvoMG

[Biomics Twinning @BiomicsTwinning]

Happening now 🚨
BIOMICS Seminar by Manuel Irimia on “Evolutionary landscapes of zygotic genome activation across animals”
📍 In-person at GIMM Lisboa + live on Zoom
#BIOMICS #Seminar #Genomics

[NMorais Lab @NMoraisLab]

@UMinho_Oficial @AKaizeler @francisca_xb @ritamtbs

[NMorais Lab @NMoraisLab]

The Lab was well represented at the Bioinformatics Open Days @UMinho_Oficial, with Nuno giving a keynote lecture and @AKaizeler, @francisca_xb, and @ritamtbs presenting posters.