Neuropsychopharmacology Reports (NPPR)

NPPR, the official publication of The Japanese Society of Neuropsychopharmacology, is an open access and peer-reviewed online journal.

[Neuropsychopharmacology Reports (NPPR) @NPPR_JSNP]

唾液中オキシトシン濃度は、自閉スペクトラム症（ASD）の有無にかかわらず、小児および思春期の対象者において、自尊心および知覚された社会的支援と関連していた。一方で、炎症マーカーとの有意な関連は認められなかった。これらの結果は、診断の有無にかかわらず、オキシトシン関連プロセスが社会情緒的機能に関与している可能性を示唆している。
https://t.co/TqfxN0CJeV

[Neuropsychopharmacology Reports (NPPR) @NPPR_JSNP]

Salivary oxytocin levels were associated with self-esteem and perceived social support across children and adolescents with and without ASD, whereas inflammatory markers showed no significant associations. These findings suggest that oxytocin-related processes may contribute to socio-emotional functioning regardless of diagnostic status.
https://t.co/TqfxN0CJeV

[Neuropsychopharmacology Reports (NPPR) @NPPR_JSNP]

Salivary oxytocin levels were associated with self-esteem and perceived social support across children and adolescents with and without ASD, whereas inflammatory markers showed no significant associations. These findings suggest that oxytocin-related processes may contribute to socio-emotional functioning regardless of diagnostic status.
https://t.co/TqfxN0CJeV

[Neuropsychopharmacology Reports (NPPR) @NPPR_JSNP]

New Article: Salivary Oxytocin and Socio-Emotional Functioning in Children and Adolescents With and Without Autism Spectrum Disorder https://t.co/wKSOANzwLm

[Neuropsychopharmacology Reports (NPPR) @NPPR_JSNP]

治療群には、アデニン、人参養栄湯、または炭酸リチウムを投与された統合失調症患者35名が組み入れられた。対照群は統合失調症患者81名で構成された。二要因混合分散分析の結果、治療により統合失調症患者の白血球数および好中球数が増加し、特に投与開始後2か月目からその傾向が認められた。
https://t.co/yg5bAZuvKB

[Neuropsychopharmacology Reports (NPPR) @NPPR_JSNP]

Thirty-five patients with schizophrenia who received adenine, Ninjin-yoei-to, or lithium carbonate were included in the treatment group. Eighty-one patients with schizophrenia comprised the control group. In the two-way mixed ANOVA, treatment increased white blood cell and neutrophil counts in patients with schizophrenia, particularly from 2 months after initiation.
https://t.co/yg5bAZtXV3

[Neuropsychopharmacology Reports (NPPR) @NPPR_JSNP]

Thirty-five patients with schizophrenia who received adenine, Ninjin-yoei-to, or lithium carbonate were included in the treatment group. Eighty-one patients with schizophrenia comprised the control group. In the two-way mixed ANOVA, treatment increased white blood cell and neutrophil counts in patients with schizophrenia, particularly from 2 months after initiation.
https://t.co/yg5bAZtXV3

[Neuropsychopharmacology Reports (NPPR) @NPPR_JSNP]

New Article: Changes in White Blood Cell and Neutrophil Counts in Patients With Schizophrenia Treated With Lithium Carbonate, Adenine, and Ninjin-Yoei-To: A Preliminary Study https://t.co/KLkFtYrFaV

[Neuropsychopharmacology Reports (NPPR) @NPPR_JSNP]

注意欠如・多動症（ADHD）の動物モデルである自然発症高血圧ラット（SHR）の側坐核において、VIP/PACAP受容体遺伝子であるVipr2の発現が選択的に亢進していたが、同遺伝子のCpGアイランドにおけるDNAメチル化レベルには変化は認められなかった。この領域特異的な過剰発現は、SHRにおけるADHD関連行動の一因となっている可能性がある。
https://t.co/QB5y12PWYD

[Neuropsychopharmacology Reports (NPPR) @NPPR_JSNP]

Expression of the VIP/PACAP receptor gene, Vipr2, was selectively upregulated in the nucleus accumbens of spontaneous hypertensive rats (SHRs), an animal model of ADHD, with no changes observed in DNA methylation levels at the CpG islands of the gene. This region-specific overexpression may contribute to ADHD-related behaviors in SHRs. https://t.co/QB5y12PWYD

[Neuropsychopharmacology Reports (NPPR) @NPPR_JSNP]

Expression of the VIP/PACAP receptor gene, Vipr2, was selectively upregulated in the nucleus accumbens of spontaneous hypertensive rats (SHRs), an animal model of ADHD, with no changes observed in DNA methylation levels at the CpG islands of the gene. This region-specific overexpression may contribute to ADHD-related behaviors in SHRs. https://t.co/QB5y12PWYD

[Neuropsychopharmacology Reports (NPPR) @NPPR_JSNP]

New Article: Vipr2 Gene Expression Is Upregulated in the Nucleus Accumbens of Spontaneous Hypertensive Rats During Early Life https://t.co/i9hw56q78d

[Neuropsychopharmacology Reports (NPPR) @NPPR_JSNP]

New Review article: Pharmacological Management, Safety, and Outcomes in Bipolar Disorder: An Integrated Narrative Review of Clinical and Translational Evidence https://t.co/fvURLK2NAK

[Neuropsychopharmacology Reports (NPPR) @NPPR_JSNP]

New Article: Vipr2 Gene Expression Is Upregulated in the Nucleus Accumbens of Spontaneous Hypertensive Rats During Early Life https://t.co/i9hw56q78d

[Neuropsychopharmacology Reports (NPPR) @NPPR_JSNP]

New Article: Changes in White Blood Cell and Neutrophil Counts in Patients With Schizophrenia Treated With Lithium Carbonate, Adenine, and Ninjin-Yoei-To: A Preliminary Study https://t.co/KLkFtYrFaV

[Neuropsychopharmacology Reports (NPPR) @NPPR_JSNP]

New Case report: Vortioxetine–Lurasidone Augmentation for Compulsive Scratching Behavior in Prader–Willi Syndrome: A Case Report https://t.co/dmqFOSlOWQ

[Neuropsychopharmacology Reports (NPPR) @NPPR_JSNP]

New Article: Clopidogrel, an ADP-P2Y12 Receptor Antagonist, Is Associated With Lower Opioid Consumption and a Reduced Incidence of Delirium in Cancer Patients Receiving Chemotherapy: A Nationwide Retrospective Cohort Study in Japan https://t.co/JV1RtnLfVD

[Neuropsychopharmacology Reports (NPPR) @NPPR_JSNP]

New Article: High Adherence to Pharmacological Treatment Guidelines in Recovery and Remission States Among Patients With Schizophrenia: A Cross-Sectional Study https://t.co/ixjGEkt65K

[Neuropsychopharmacology Reports (NPPR) @NPPR_JSNP]

New Article: Salivary Oxytocin and Socio-Emotional Functioning in Children and Adolescents With and Without Autism Spectrum Disorder https://t.co/wKSOANzwLm

[Neuropsychopharmacology Reports (NPPR) @NPPR_JSNP]

New Article: Real-World Vortioxetine Prescription for Patients With Major Depressive Disorder in Japan: A Retrospective Cohort Study Using a Japanese Health Insurance Claims Database https://t.co/kX31axEyyE

[Neuropsychopharmacology Reports (NPPR) @NPPR_JSNP]

New Article: Sex Difference in Effect of the OPRM1 Gene A118G (rs1799971) Single-Nucleotide Polymorphism on the Requirement for Postoperative Fentanyl in Japanese Patients Who Underwent Laparoscopic-Assisted Colectomy https://t.co/qGPGpjLZ6q

[Neuropsychopharmacology Reports (NPPR) @NPPR_JSNP]

Mitochondrial dysfunction is implicated in depression, and a pillow-based ELF-ELME device for nighttime use improved depressive symptoms in a preliminary 8-week open-label study of MDD without adverse events. This non-invasive intervention may offer a safe and feasible adjunctive treatment option.
https://t.co/zKi6KQHRCV

[Neuropsychopharmacology Reports (NPPR) @NPPR_JSNP]

New Article: A Preliminary Open-Label Pilot Study of a Pillow-Based ELF-ELME (Extremely Low-Frequency, Extremely Low Magnetic Environment) Intervention for Major Depressive Disorder
https://t.co/cYbr6Oqvba

[Neuropsychopharmacology Reports (NPPR) @NPPR_JSNP]

New Article: A Preliminary Open-Label Pilot Study of a Pillow-Based ELF-ELME (Extremely Low-Frequency, Extremely Low Magnetic Environment) Intervention for Major Depressive Disorder
https://t.co/cYbr6Oqvba

[Neuropsychopharmacology Reports (NPPR) @NPPR_JSNP]

ADHDの症状は幸福感の低下と関連しており、その関連は主に身体的および精神的健康要因――特に身体症状、混乱・集中困難、うつ症状――によって媒介されていた。このことは、ウェルビーイングを向上させるためには、こうした変更可能な媒介因子に焦点を当てることが重要であることを示唆している。 https://t.co/VU6hH7vbB5

[Neuropsychopharmacology Reports (NPPR) @NPPR_JSNP]

ADHD symptoms were associated with lower happiness, largely mediated by somatic and mental health factors—particularly physical symptoms, confusion/difficulty concentrating, and depression—highlighting the importance of targeting these modifiable mediators to improve well-being.
https://t.co/VU6hH7vbB5

[Neuropsychopharmacology Reports (NPPR) @NPPR_JSNP]

せん妄は、神経伝達物質の不均衡と神経ネットワークの障害を伴います。ラコサミドは、ナトリウムチャネルの調節を介して神経過興奮性を抑制することで理論的にはせん妄を治療できる可能性がありますが、臨床的証拠は不足しています。腸管神経系にナトリウムチャネルが存在するため、ラコサミドは抗コリン作用経路とは無関係に消化管運動障害を引き起こす可能性があります。これらのリスクと腸脳軸への潜在的な障害を考慮すると、適応外使用には極めて慎重な注意と厳格なモニタリングが必要です。　https://t.co/BUQnFuW9rn

[Neuropsychopharmacology Reports (NPPR) @NPPR_JSNP]

Delirium involves neurotransmitter imbalances and disrupted neural networks. Although lacosamide may theoretically treat delirium by reducing neuronal hyperexcitability via sodium channel modulation, clinical evidence is lacking. Sodium channels in the enteric nervous system mean lacosamide can cause gastrointestinal dysmotility independent of anticholinergic pathways. Given these risks and potential disruptions to the gut-brain axis, off-label use requires extreme caution and rigorous monitoring.
https://t.co/BUQnFuWHgV

[Neuropsychopharmacology Reports (NPPR) @NPPR_JSNP]

我々は、青年期におけるニコチン、エタノール、またはそれらの組み合わせへの慢性的な曝露が、成人期におけるニコチンに対する条件性場所選好（CPP）にどのような影響を与えるかを調査した。薬物曝露群のいずれにおいても有意なCPPは観察されず、青年期における依存性物質への曝露がニコチン報酬に対する脆弱性を一律に高めるわけではないことが示唆された。 https://t.co/gSCUokd0k2

[Neuropsychopharmacology Reports (NPPR) @NPPR_JSNP]

We investigated how chronic exposure to nicotine, ethanol, or their combination during adolescence influences adult conditioned place preference (CPP) for nicotine. No significant CPP was observed in any of the drug-exposed groups, suggesting adolescent exposure to addictive substances does not uniformly increase vulnerability to nicotine reward.
https://t.co/gSCUokd0k2