Nikolaos V. Tzouras

Alexander Von Humboldt Fellow (RUB)
DSc (UGent)/PhD (UoA) - organometallic chemistry and catalysis
MSc - organic synthesis

[Nikolaos V. Tzouras @NVT_NHC]

A truly impressive palladium catalyst enables mild cross-coupling of challenging substrates and applications in late-stage functionalization of drug molecules.
Stay tuned for more of this chemistry coming soon.

[Sourav Manna @SouravM69071347]

MeNAP strikes again ⚡.
What if the real bottleneck isn’t the catalytic cycle—but catalyst activation?Our MeNAP–Pd triflate precatalyst rapidly generates active Pd(0), enabling N-arylation of sulfoximines with aryl chlorides at room temp.
https://t.co/iurvuuJjx8

[Nikolaos V. Tzouras @NVT_NHC]

https://t.co/Gvrj9aPH7p

[Nikolaos V. Tzouras @NVT_NHC]

After years of experience with Au(I)‐Aryls, we introduce a new synthetic route based on the use of aqueous ammonia, while presenting pitfalls (and some guidelines) regarding the transmetallation of arylboronic acids to gold @ChemEurJ @wileyinresearch
https://t.co/sqAdTDjYgg

[Nikolaos V. Tzouras @NVT_NHC]

Honored to be awarded the first EurJOC-KVCV-SRC Prize by @BeKvcv @EurJOC @ChemEurope at the @merckgroup MOCS2025 in Blankenberge. Returning two years after the Incentive award was an indescribable experience. Grateful to my mentors, Steven Nolan, @Vougioukalakis and @Nahra_Chem

[Nikolaos V. Tzouras @NVT_NHC]

Mild cross-coupling of bulky tertiary alkoxides with aryl chlorides enabled by a unique palladium NHC complex - appears in Chemical Communications https://t.co/Ofj8uXCunH
The catalyst will be made commercially available by @UmicoreM14365 @UmicoreGroup
Funded by @AvHStiftung

[Nikolaos V. Tzouras @NVT_NHC]

Congratulations to Jie for leading this challenging project on Palladium catalyzed C-F Amination and Para‐C─H Arylation - appears in @angewandte https://t.co/NzqlbBwLYr
Co-funded by @AvHStiftung

[Nikolaos V. Tzouras @NVT_NHC]

As always, very interesting hydrofluorination chemistry coming from the Paquin group - this time using the simplest Au-NHC catalyst: https://t.co/E2mmW4hMjP
Very grateful to see some of our complexes being used in such well-designed and innovative systems.

[Nikolaos V. Tzouras @NVT_NHC]

Selenium insertion into gold-carbon bonds: one of the two synthetic routes leading to a new generation of organometallic compounds with promising in vitro and ex vivo anticancer activity - now published in Chemical Science https://t.co/OB2XUMzHe9

[Chemistry News @ChemistryNews]

A New Generation of N-Heterocyclic Carbene (NHC) Gold-Selenolato Complexes as Potent Anticancer Agents: Distinct Synthetic Routes and Evaluation in 2D and 3D Cancer Models https://t.co/SsXsowqSFE

[Chemical Communications @ChemCommun]

New Communication from Jean-François Paquin, Raphaël Pronovost, Mathis Rion, Nikolaos V. Tzouras, Steven P. Nolan @jfluorine

'Gold-catalyzed hydrofluorination of terminal alkynes using potassium bifluoride (KHF2)'

https://t.co/BECYz2nlgv

[Nikolaos V. Tzouras @NVT_NHC]

Selenoureas reacting like carbenes in the presence of a phosphine? A paper 5 years in the making since the 1st reaction was done with @Nahra_Chem
@ChemEurJ: https://t.co/neroPB58tp
Thanks to @Vougioukalakis, D. J. Nelson, @XStruct_group + funding and institutions involved

[Nikolaos V. Tzouras @NVT_NHC]

@ThomasScattoli1 @ChemicalScience @OrganoMetalsPD @discunipd @MCDietl @_LauraOrian Congrats Thomas, nicely done and very interesting compounds

[Georgios C. Vougioukalakis @Vougioukalakis]

A very efficient strategy to synthesize azines bearing a guanidine core from NHC-derived selenoureas and diazo reagents just published in @ChemEurJ: https://t.co/04MpckkFFi (soon OA). Congrats to Stathis & @NVT_NHC and thank you to @uoaofficial @ELIDEK_HFRI & our collaborators.

[Nikolaos V. Tzouras @NVT_NHC]

Gold-alkoxides that are stable, accessible in 30 min under air, yet still reactive:
Synthesis and reactivity of N-heterocyclic carbene (NHC) gold-fluoroalkoxide complexes - now published in Dalton Transactions https://t.co/pC48YJNl2f

[Nikolaos V. Tzouras @NVT_NHC]

Glad to see this benzotriazole-based Carbene-Metal Amides story published in @DaltonTrans
Many thanks to all our colleagues from @uoaofficial and @ugent
Nice to have a star on this one, more soon
@Vougioukalakis @XStruct_group @Subh_Bhandary @npozsoni
https://t.co/qRCw8tDq63

[Georgios C. Vougioukalakis @Vougioukalakis]

Our new NHC-Au/Ag/Cu benzotriazolyl complexes, active in propargylamide cycloisomerization and carbonyl hydrosilylation, just published @DaltonTrans #OpenAccess! Congrats Angie & @NVT_NHC! Thank you: to our co-workers @ugent & @uoaofficial, @ELIDEK_HFRI https://t.co/nZg1JYgkVo

[Nikolaos V. Tzouras @NVT_NHC]

Glad to see our work in @ACSCatalysis highlighted in Advances in Engineering: https://t.co/gQ2MwD5As0
Thanks to the editors and the selection team of Advances in Engineering for this recognition.
@Vougioukalakis @uoaofficial @ugent @ELIDEK_HFRI @FWOVlaanderen

[Nikolaos V. Tzouras @NVT_NHC]

@Subh_Bhandary @XStruct_group @AnnaMKaczmarek1 @J_A_C_S @FWOVlaanderen @ResearchUGent Congratulations Subhrajyoti, great work.

[Nikolaos V. Tzouras @NVT_NHC]

@PapageorgiouLab @uoaofficial @Vougioukalakis Thank you!

[Nikolaos V. Tzouras @NVT_NHC]

I would like to thank the editors of https://t.co/blie4aZci2 for announcing the good news @uoaofficial @Vougioukalakis:
https://t.co/OCLwMTLGR8
https://t.co/p2tuJ04zpv

[Nikolaos V. Tzouras @NVT_NHC]

@sofiak1r @uoaofficial @Vougioukalakis Thank you