Nature Rev Neurosci

Nature Reviews Neuroscience features reviews, perspective articles and the latest research news. Tweets are from the editors.

[Dayu Lin @moccalin]

Happy to share our new review on Neural Mechanisms of Social Hierarchy across Species. We discussed how different individuals in various species, from fish to humans, achieve high social status and the neural circuits supporting each of those strategies.
https://t.co/4mxuXbqbHU

[Agustin Ibañez @AgustinMIbanez]

Brain–body-environment interactions must move beyond isolated exposures toward the expotype: the dynamic configuration of physical, social, lifestyle, and internal factors that jointly shape brain–behaviour phenotypes. At @NatRevNeurosci (https://t.co/FIMA1E1dxM), we propose a future agenda to assess the exposome as a complex, time-varying system that requires nonlinear models to capture interactions, thresholds, synergistic effects, and cross-domain buffering mechanisms. Although predictive machine learning can support individual risk estimation, the next frontier is to move from prediction to mechanism, from association to dynamic synergetic inference. Multivariate learning, causal machine learning, aging clocks, longitudinal designs, and generative biophysical digital twins are beginning to provide this bridge. Brain–body–environment diversity can reveal how ecology becomes biologically embedded. We call for a future exposomic neuroscience that integrates nonlinear temporal modeling, generative mechanisms, and population diversity to understand, simulate, and modify trajectories of brain aging and disease. Congrats Sarah Genon, @MasoudTahmasian & @INM7_ISN

[Nature Rev Neurosci @NatRevNeurosci]

Linking the exposome to the brain–behaviour phenotype — a Perspective by Sarah Genon, Agustin Ibanez, Masoud Tahmasian & Simon B. Eickhoff

https://t.co/ztvRmpQ5Os

[Nature Rev Neurosci @NatRevNeurosci]

Neural basis of social hierarchy across species — a Review by Rongzhen Yan & Dayu Lin

https://t.co/kHohup2Ydk

[Nature Rev Neurosci @NatRevNeurosci]

Rethinking hierarchy: the auditory system as an integrated cortical–subcortical network — a Review by Michael Lohse, Ben D. B. Willmore & Andrew J. King

https://t.co/p5FlxgXTvd

[Nature Rev Neurosci @NatRevNeurosci]

Large-scale electrophysiology at single-spike resolution — a Review by Joshua H. Siegle & Nicholas A. Steinmetz

https://t.co/LDnMNDCboO

[Nature Rev Neurosci @NatRevNeurosci]

Wired for immunity: neuroimmune control of the lung by sensory neurons — a Review by Anna M. Ehlers, Idaira M. Guerrero-Fonseca, Christophe Altier, Bryan G. Yipp & Sebastien Talbot

https://t.co/CssOaBG8FG

[Nature Rev Neurosci @NatRevNeurosci]

A social readout of circuit imbalance — a Journal Club article by Baolin Guo

https://t.co/WPM6EbjTA0

[Nature Rev Neurosci @NatRevNeurosci]

Making the primate cortex ‘see’ with mesoscale optogenetics — a Tools of the Trade article by Hao Li (李昊)

https://t.co/pzs1b3LNO6

[Nature Rev Neurosci @NatRevNeurosci]

Categorization is ‘baked’ into the brain — a Perspective by Lisa Feldman Barrett & Earl K. Miller

@LFeldmanBarrett @MillerLabMIT

https://t.co/gDGnwN2Iom

[Nature Rev Neurosci @NatRevNeurosci]

Opportunities and pitfalls of data contextualization in neuroimaging — a Roadmap by Jessica Royer, Casey Paquola, Sara Larivière, Justine Y. Hansen, Sofie L. Valk, Bratislav Misic, Robert Leech, Jonathan Smallwood & Boris C. Bernhardt

https://t.co/TghI7st0kU

[Mari Sanchez-Mico @mariv_sm]

So excited to share our latest review in @NatRevNeurosci highlighting the role of astroglial calcium in aging and neurodegenerative diseases https://t.co/AgZ8EwL03V

[Nature Rev Neurosci @NatRevNeurosci]

Role of dysregulated calcium homeostasis in astrocytes in neurodegenerative disorders — a Review by Maria V. Sanchez-Mico, Maria Calvo-Rodriguez & Brian J. Bacskai

https://t.co/ljL76BF9ZZ

[Nature Rev Neurosci @NatRevNeurosci]

Clarifying the conceptual dimensions of representation in neuroscience — a Perspective by Stephan Pohl, Edgar Y. Walker, David L. Barack, Jennifer Lee, Rachel N. Denison, Ned Block, Florent Meyniel & Wei Ji Ma

https://t.co/6Tap2kIZgZ

[Nature Rev Neurosci @NatRevNeurosci]

The gatekeeper of ongoing pain: an endogenous analgesic circuit that prioritizes survival — a Journal Club article by Sora Shin

https://t.co/gECZZyiQrj

[Nature Rev Neurosci @NatRevNeurosci]

Neural adaptation to climate change: mechanisms, limits and opportunities — a Comment article by Jan Siemens & Patrick Haggard

https://t.co/NxLO6iRDKK

[The Brain Prize @BrainPrize]

Warm congratulations to The Brain Prize winners 2026, Professor David Ginty and Professor Patrik Ernfors, for their pioneering work on how the nervous system detects and processes touch and pain.

@hhmi_science

#Neuroscience #BrainPrize2026

[Nature Rev Neurosci @NatRevNeurosci]

Mitochondrial dynamics in neurodevelopment and neurodevelopmental disorders — a Review by Carissa L. Sirois, Jiyoun Lee, Audrey L. Chambers & Xinyu Zhao

https://t.co/hJBDJJBbUG

[Nature Rev Neurosci @NatRevNeurosci]

Redefining the central pattern generator for vertebrate locomotion — a Review by Abdeljabbar El Manira

https://t.co/VYmIS1HMKf

[Ali Mahmoodi @alimahmoodi88]

We review studies showing that when brain areas face similar computational demands in social and non-social context, they perform the same computations. We argue that exaptation (repurposing of traits for new functions) played a key role in brain evolution.