Nick Banovich

Husband, Dad, Associate Professor at @TGen. Interested in functional genomics of disease. Also like trout.

[Nick Banovich @NeBanovich]

I started my Twitter account in January of 2014. I've used this platform to connect with my professional network and find exciting science. Over the past year the experience has degraded. I'm moving over to @bluesky as my platform of choice, with limited cross posting here.

[Maor Sauler @maorsauler]

Excited to share this work, now out in @NatureGenet . There is no cure for #COPD. To tackle this challenge, we performed nuclear sequencing, spatial transcriptomic, and proteomic analysis of lung tissue from 141 subjects to better understand this disease. https://t.co/XMPSDXzEkt

[Francesca Polverino @FrancyPolverino]

@NeBanovich @maorsauler led this, kudos to him for this herculean effort that is going to move the field of COPD forward. And..Hi friends ;)

[Nick Banovich @NeBanovich]

Amazing study! Grateful to Francy and Maor for letting us be a small part of this project.

[Maor Sauler @maorsauler]

Excited to share this work, now out in @NatureGenet . There is no cure for #COPD. To tackle this challenge, we performed nuclear sequencing, spatial transcriptomic, and proteomic analysis of lung tissue from 141 subjects to better understand this disease. https://t.co/XMPSDXzEkt

[Nick Banovich @NeBanovich]

Short answer is yes! A single sample can be prepped with both chemistries and through two sequential runs you can have Prime and V1 data from the same cells. Data are highly correlated with single chemistry runs – with a small drop in sensitivity on the prime.

[Nick Banovich @NeBanovich]

A fun little project. We were curious if you could prep a single sample using both 10X Genomics Xenium V1 probes and Prime probes – allowing users to profile 480 genes at high sensitivity and 5,000 genes at lower sensitivity inline. https://t.co/dfx0Syans9

[Nick Banovich @NeBanovich]

Great new work led by Aaron Kwok from Davis McCarthy’s group. A tool to “denoise” contaminating transcripts from image based spatial data.

https://t.co/cqa7i7xzJL

[Jonathan Pritchard @jkpritch]

I want to try something again at #ASHG25 this year: I'll block some time on Thursday and Friday afternoons to meet with trainees who would be interested to chat on any topic.
I did this last year and it was great to meet a whole bunch of new people, at all career stages!

[euan ashley @euanashley]

Atul Butte died yesterday.
The world lost a giant.
A big bear of a man.
With a huge smile.
With love for everyone.
With energy that could power a room.
I loved everything about Atul.
I loved how he was always happy.
I loved how excited he was about science and helping people.

[Jen Srygley Sucre @sucre_jen]

Overjoyed to share the 1.2 million spatially-resolved cells from lungs in various stages of development and injury, led by @saahithi_4708 @NeBanovich @JKropski in partnership with @shawyonshirazi, Laurie Eldredge, and Gail Deutsch. Full data explorer here: https://t.co/pv11hAEP0u

[Nick Banovich @NeBanovich]

Proud mentor altert!!!!

Excited to share @saahithi_4708's first manuscript from head school!

[Saahithi Mallapragada @saahithi_4708]

I am so excited to share the Banovich Lab's most recent work & my first big project as a graduate student! We used spatial transcriptomics to study cell-cell communication in human lung development. Here’s the full study: https://t.co/Y8y1giM0e4
(1/17)

#lung #genomics #bpd

[Harvard University @Harvard]

“No government—regardless of which party is in power—should dictate what private universities can teach, whom they can admit and hire, and which areas of study and inquiry they can pursue.” - President Alan Garber https://t.co/6cQQpcJVTd

[Francesca Polverino @FrancyPolverino]

We’re recruiting a postdoc to join our lab through our T32 training program. U.S. citizenship or green card required. We study COPD and asthma using both human and experimental models. Reach out if you’re interested or want to learn more
https://t.co/s0rVghi3Gd

[Sharareh Gholamin @Shararehshgh]

As our understanding of resistance in solid tumors deepens, we’re excited to share our latest study, now live on bioRxiv:
https://t.co/a3TyltwzSm

[Nick Banovich @NeBanovich]

This is the product of a fantastic collaboration, building on 8 years of work w/ Christine Brown. However, the true superstars of this study are Heini Natri from my group and @Shararehshgh from Christine’s. They did an amazing job leading this study and I’m so proud of the work.

[Nick Banovich @NeBanovich]

Excited to share our new work exploring strategies to overcome resistance to CAR T cell therapy in solid tumors. Using scRNA-seq, mouse models, and functional studies, our work points to SPP1 signaling in the TME as a critical component of this resistance. https://t.co/Qm19wnInKK

[Nick Banovich @NeBanovich]

Finally, we demonstrate that blocking SPP1 in the JAK1 KO model and a mouse glioma model resulted in dramatic therapeutic improvement and broad remodeling of the suppressive TME. We are excited to push this work forward and work to improve outcomes for patients with solid tumors.