Carlos Villavicencio

🇲🇽 Mexican Nephrologist | 🎓Universidad de Guadalajara @nefrohgr46 | 🔬 Glomerular Disease Fellow @GlomCon | 🌎 Traveler

[Carlos Villavicencio @Nephroaholic]

En el 52° Congreso de la Sociedad Española de Nefrología @SENefrologia #Senefro22 con amigos del @nefrohgr46 🇲🇽 y @FJDNefrologia 🇪🇸

[Nefrología ISSSTE Tepic @NefrologiaTepic]

¿QUIERES SE RESIDENTE DE NEFROLOGÍA? 🔥🔝😎

Fecha límite pre-registro 🆘 26 de Julio 2026

Te compartimos la convocatoria del ISSSTE⬇️ https://t.co/1cYIgCiUmx

Si te interesa saber sobre nuestra sede 👀sigue leyendo ➡️➡️➡️

[Nefrología ISSSTE Tepic @NefrologiaTepic]

Plasmaféresis en paciente con MAT por SAF/LES Y GNRP🤓

[Nefrología ISSSTE Tepic @NefrologiaTepic]

Trabajo aceptado en el Congreso Mundial de Nefrología 2026 en Yokohama, Japón 🇯🇵 por residente de primer año de nefrología @MORALESROJA03

[Nefrología ISSSTE Tepic @NefrologiaTepic]

Biopsia de injerto renal guiada por ultrasonido

[Nefrología ISSSTE Tepic @NefrologiaTepic]

Colocación de catéter tunelizado femoral en paciente con estenosis venosa central

[Nefrología ISSSTE Tepic @NefrologiaTepic]

Colocación de catéter no tunelizado guiado con ultrasonido por residente de primer año.

[Nefrología ISSSTE Tepic @NefrologiaTepic]

Primera generación de nefrólogos que será formada en el Estado de Nayarit.

[Carlos Villavicencio @Nephroaholic]

@OscarTahuahua Muchas gracias amigo, a ponernos a leer.

[Laura Fuentes Méndez @laufuentesm]

Finally, graduation day is here! . Grateful for the opportunity to learn from talented colleagues who share my passion for glomerular diseases. It's an incredible experience.Thank you for all the support and knowledge gained. @GlomCon #HouseofPodocytes #glomerulardiseases

[Carlos Villavicencio @Nephroaholic]

@RoRvm Ufff chulada jajaja ojalá alguien siga la bonita costumbre de preguntar eso en las entregas 🤙🏼

[Carlos Villavicencio @Nephroaholic]

📚References:

1⃣ DOI: https://t.co/NeD4OCcWzo
2⃣ DOI: 10.1097/MNH.0000000000000358
3⃣ DOI:10.1159/000517259
4⃣ DOI: 10.2215/CJN.00280121
5⃣ DOI: 10.1056/NEJMc1202500
6⃣ DOI: https://t.co/ppGdjp3DUQ

[Carlos Villavicencio @Nephroaholic]

The identity of the circulating permeability factor is not known. The main suspects are:

•Serum soluble urokinase plasminogen activator receptor (suPAR)
•Apolipoprotein A1 (apoA-1)
•C-C motif chemokine ligand (CCL)
•Anti-CD40 autoantibody
•Anti-nephrin antibody

📚6⃣

[Carlos Villavicencio @Nephroaholic]

I hope you find it useful. Thank you for your time.

[Carlos Villavicencio @Nephroaholic]

However, several reports support the theory of a circulating factor:

1.- Serum increases in vitro glomerular permeability
2.- Plasma exchange can reduce protein excretion (which increases when injected into rats)
3.- Retransplation with complete resolution

📚5⃣

[Carlos Villavicencio @Nephroaholic]

Role of Electron Microscopy:

EM in the setting of transplant kidney biopsies plays a crucial role.

FSGS evolves from early podocyte foot process effacement (Hours to weeks) "Minimal change phase" to focal and segmental sclerosis and finally to diffuse sclerosis.

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[Carlos Villavicencio @Nephroaholic]

Mechanisms:

Is still largely unknown, although the presence of a circulating factor toxic to podocytes is highly suggestive.

📚4⃣

[Carlos Villavicencio @Nephroaholic]

Risk Factors:

1.- Agressive native disease
2.- Diagnosis at a younger age
3.- Severe proteinuria
4.- Nephrectomy
5.- Prior recurrence
6.- Lower BMI at trasplantation

📚2⃣

[Carlos Villavicencio @Nephroaholic]

Let's start with Recurrent Primary FSGS:

1.- Recurrence rates vary from 30%–60%
2.- Presenting immediately or within months
3.- Clinical signs include hypertension, proteinuria (nephrotic range) and allograft dysfunction
4.- Resistant disease and graft loss remain common

📚2⃣

[Carlos Villavicencio @Nephroaholic]

First of all, what is the importance of the recurrence of a glomerular disease?

1.- Important cause of allograft failure
2.- Reported rates vary from 2.6% to 50%
3.- The risk of recurrence is based on the type of GN
4.- Limitations to accurate treatment of recurrent GN

📚1⃣