Collin Nadarajah

MD/PhD Candidate | Washington University School of Medicine @ErikMusiek Lab Alum. Glia and neurodegeneration

[Collin Nadarajah @Neuro_Nada]

A week ago, I defended my PhD thesis about the role of REV-ERBs in astrocytes in neurodegeneration. None of this was possible without the support of my family, my PI, my wonderful lab and my friends. Now onwards into clinic

#PhDone #mstp #washumed

[Erik Musiek @ErikMusiek]

REV-ERBa/b DKO causes massive changes in brain gene expression and induces cell-autonomous astrocyte reactivity, enhancing aSyn degradation and lysosomal fxn in vitro, and mitigating aSyn spreading in vivo. These finding further support REV-ERB inhibition as a therapeutic target.

[Collin Nadarajah @Neuro_Nada]

Excited that my thesis work from @ErikMusiek lab is out now! We describe the role of REV-ERB alpha and beta in regulating key neurological phenotypes, including modulating astrocyte reactivity and function in a cell-autonomous manner. Out in @PNASNews now

[Erik Musiek @ErikMusiek]

Please that @Neuro_Nada's paper in REV-ERBs is out today in @PNASNews. It shows that deletion of REV-ERB alpha & beta unmasks striking phenotypes.

REV-ERB-alpha and -beta coordinately regulate astrocyte reactivity and proteostatic function | PNAS https://t.co/bliMnCGOQw

[Erik Musiek @ErikMusiek]

Please that @Neuro_Nada's paper in REV-ERBs is out today in @PNASNews. It shows that deletion of REV-ERB alpha & beta unmasks striking phenotypes.

REV-ERB-alpha and -beta coordinately regulate astrocyte reactivity and proteostatic function | PNAS https://t.co/bliMnCGOQw

[Collin Nadarajah @Neuro_Nada]

Making a thesis defense presentation while my street got hit by the #STL #Tornado yesterday. Thankfully, I’m alright. God is sending a message but I’m not sure what it is.

[Collin Nadarajah @Neuro_Nada]

Thesis has been submitted and in 2 weeks, it’s Defense time #PhDlife #MSTP

[Collin Nadarajah @Neuro_Nada]

Turning 30 today and this decade is going to bring some fun and interesting things real soon:

-Defending my PhD Thesis in a couple months
-Going back to med school in June
-Go to residency and learn how to be physician

[Collin Nadarajah @Neuro_Nada]

4 years ago on #ElectionDay , I was studying for Cardio, Pulm, Renal, and Path block exams that week (that was a fun time 😅)

Now during #Election2024 I’m putting together my first solo first author manuscript.

Times change and yet the stress and deadlines remain

[Collin Nadarajah @Neuro_Nada]

the weirdest places I’ve seen the Eduroam WIFI so far: a small monastery on a lake an hour outside Munich and the Dachau concentration camp memorial

[Erik Musiek @ErikMusiek]

MSTP student extraordinaire @Neuro_Nada delivering his talk on astrocyte REV-ERBs at #CSHLglia. It's a big stage but he did very well. My first time at the meeting and it was great. Thanks to @ErinMGibson for highlighting our glial circadian translatome paper.

[Collin Nadarajah @Neuro_Nada]

Very rewarding to see all of Michelle’s hard work and persistence pay off. Fantastic student and budding scientist.

[Erik Musiek @ErikMusiek]

Congrats to super-student Michelle Li and her bench mentor @Neuro_Nada on winning best undergraduate poster at the @WUADRC pre-AAIC poster session!

[Collin Nadarajah @Neuro_Nada]

The only time I’ll be able to post this. Started the MSTP as a bright eyed 24 year old. Now hopefully in the second half 😅😅

[Collin Nadarajah @Neuro_Nada]

I’ve only written the wrong year on my samples twice so far. It’s the small joys.

[Collin Nadarajah @Neuro_Nada]

Lab has been rough of late but that doesn’t matter…

THE TEXAS RANGERS ARE AMERICAN LEAGUE CHAMPIONS!!!

#GoAndTakeIt

World Series here we come!!

[Pat Sheehan @patwsheehan]

Very happy to finally present my PhD paper in the Musiek lab where we find astrocyte activation via loss of Bmal1 abrogates intra-neuronal tau/synuclein pathology! We also find Bag3 upregulation in a cluster of astrocytes in human AD patients that resemble DAA astrocytes! 👇

[Erik Musiek @ErikMusiek]

Excited to share @patwsheehan and @Neuro_Nada's new paper with @GusDavisLab out in @NeuroCellPress! Circadian clock disruption via Bmal1 KO protects against tau and synuclein pathology. How can this be? It’s the astrocytes! This led us to astrocyte BAG3 as a protective response.

[Collin Nadarajah @Neuro_Nada]

Our @NeuroCellPress paper is finally out! We found a Bmal1-Bag3 axis in Astrocytes that is protective against Tau and Synuclein pathology! Check out the thread from fellow first-author @patwsheehan who spearheaded this awesome project

[Pat Sheehan @patwsheehan]

Very happy to finally present my PhD paper in the Musiek lab where we find astrocyte activation via loss of Bmal1 abrogates intra-neuronal tau/synuclein pathology! We also find Bag3 upregulation in a cluster of astrocytes in human AD patients that resemble DAA astrocytes! 👇

[Collin Nadarajah @Neuro_Nada]

@KeystoneSymp #KSNeurodegen23 #KSNeuroimmune23 was a fantastic experience! Seeing the forefront of groundbreaking research/therapy was incredibly heartening, and presenting our own was rewarding. Plus swam in a Canadian lake, had great food, and marveled at wondrous vistas

[Guoyan Zhao @gzhao11]

Thrilled to find out that our prediction of BAG3 regulation of tau aggregation in astrocytes published in https://t.co/dEUTn3mRTJ has been validated by Collin Nadarajah @Neuro_Nada in the @ErikMusiek lab at #KSNeurodegen23 #KSNeuroimmune23 @KeystoneSymp poster presentation!

[Collin Nadarajah @Neuro_Nada]

@gzhao11 @ErikMusiek @KeystoneSymp @KeystoneSymp working as intended: connecting scientists and facilitating the sharing of cool science. Encouraging others found what we see! #KSNeurodegen23 #KSNeuroimmune23