Asymmetric allylation of oxetanones and azetidinones from @KrischeLab@nicholas_1658.
Enantioselectivity possible via enantiotopic π-facial discrimination of the transient σ-allylmetal nucleophiles due to the chiral cyclometallated iridium catalyst. https://t.co/ndBfpVTfSj
Congratulations to Nick and his team for their 50-example study on the asymmetric allylation of oxetanones and azetidinones – all things symmetric deserve a twist! https://t.co/mVozyntLvY @ACSCatalysis
#TotalSynthesis of the Acetyl CoA Carboxylase Inhibitor Soraphen A: Asymmetric Tsuji Reduction Enables Successive Olefin Metathesis by Tabitha T. Schempp and Michael J. Krische @KrischeLab@UTChemistry in @J_A_C_S https://t.co/xMhDlVuwXB
Congratulations to Cole, Nick, and Mel for demonstrating the utility of ethanol as an abundant renewable feedstock in catalytic enantioselective C-C coupling. Time for some EtOH consumption to celebrate! https://t.co/QNivc0OJZu