Nienke van Hoogenhuijze

PhD student #reproductivemedicine @UtrechtUniversity | MD | fertility physician @UMCUtrecht

[Frank Broekmans @FrankBroekmans]

De 200ste inclusie in SCRaTCH OFO gevierd.. in het Diac Utrecht...

[Nienke van Hoogenhuijze @Nienke_vanH]

Happy to announce that the results of the SCRaTCH trial are online and downloadable! https://t.co/ctnuGgpMF2 Next steps: finish the IPD on this topic... to be continued

[Nienke van Hoogenhuijze @Nienke_vanH]

Looking back at a great ESHRE Annual Meeting with our research team! Many new experiences during this all-online event 🖥️🎙️#ESHRE2020 #ESHREvirtual @SchoutenNienke @FrankBroekmans @UMCUtrecht

Thanks to the organising committee for their hard work! @ESHRE

[Nienke Schouten @SchoutenNienke]

Behind the scenes, presenting our study results at ESHRE 2020: contole center Nienke H & Nienke S #ESHRE2020 #ESHREvirtual @ESHRE @Nienke_vanH @UMCUtrecht

[Nienke van Hoogenhuijze @Nienke_vanH]

Still cannot conclude if (and/or for whom) endometrial scratching works. 3 large trials (with different populations) had different results. To be continued... #IPD #ESHRE2020

[Frank Broekmans @FrankBroekmans]

ESHRE presentation by Nienke van Hoogenhuijze: Endometrial SCRaTCHing in RIF conditions: show is not over, wait for the IPD...

[Frank Broekmans @FrankBroekmans]

ESHRE presentation by Nienke van Hoogenhuijze: Endometrial SCRaTCHing in RIF conditions: show is not over, wait for the IPD...

[Nienke van Hoogenhuijze @Nienke_vanH]

Interesting new model on dose selection! @SchoutenNienke

[Rui Wang @RuiWangMD]

Nienke Schouten from @UMCUtrecht will be presenting our #IPDMA on gonadotropin dose selection model for #individualised ovarian stimulation in session 32 #ESHRE2020
@FrankBroekmans @bwmol

[Nienke van Hoogenhuijze @Nienke_vanH]

@maclaudiaa @ESHRE @FrankBroekmans @samueldsribeiro @MackensShari #ESHREjc Thanks for the invitation @maclaudiaa and great to see how this topic resulted in a lively discussion 👏
Very inspiring to exchange thoughts with so many experts!

[Nienke van Hoogenhuijze @Nienke_vanH]

@jd_wilko @ProfJoyceHarper @susan_bewley @MaxEzzatiMD @pash22 @uberbarrensclub @MinaNMincheva @AllanPacey @RuiWangMD @RitaVassena @germcells @SIGPsyCounsel @dremilybarnard @CindyFarquharNZ @jimgthornton @p_saunder @NHSEngland @HFEA @FertilityNUK @deb_cohen @carlheneghan @FertilityFest @Tommys_baby @bpas1968 @NICEComms @mdimairo Yes! We'll present our final results (with 12-month follow-up) @ESHRE virtual meeting (O-076) #ESHREjc #ESHRE2020

Curious to see the results of the Endometrial Scratch Trial as well @metwally01

[Nienke van Hoogenhuijze @Nienke_vanH]

@susan_bewley @jd_wilko @MaxEzzatiMD @pash22 @uberbarrensclub @MinaNMincheva @AllanPacey @RuiWangMD @RitaVassena @ProfJoyceHarper @germcells @SIGPsyCounsel @dremilybarnard @CindyFarquharNZ @jimgthornton @p_saunder @NHSEngland @HFEA @FertilityNUK @deb_cohen @carlheneghan @FertilityFest @Tommys_baby @bpas1968 @NICEComms Possible harm should not be overlooked - that's why it's important to have follow-up until live birth, and include pregnancy complications and parameters such as birth weight.
Luckily the latest RCTs also registered (some of) these parameters #ESHREjc

[Nienke van Hoogenhuijze @Nienke_vanH]

@RuiWangMD @maclaudiaa @SofiaMakieva @jd_wilko Agree with this order of logical studying; but where to start looking for the biomarker 🩸?
In the IPD? Or by searching for tissue markers🔬🧬?
#ESHREjc

[Nienke van Hoogenhuijze @Nienke_vanH]

@maclaudiaa @LaurCraciunas @samueldsribeiro Some studies do describe exactly what they did, but there is no single guideline for how to do it. So I guess everyone tries to come up with the best method #ESHREjc

[Nienke van Hoogenhuijze @Nienke_vanH]

@MackensShari @LaurCraciunas @SofiaMakieva Exactly. It all started in search for the underlying biology, but then was quickly overtaken by studies on efficacy. These two should go more hand in hand: the possible biology could help us direct whether to continue our search and also which timing / method to apply #ESHREjc

[Nienke van Hoogenhuijze @Nienke_vanH]

@LaurCraciunas Based on the current evidence we can neither say that it does work nor that it doesn't work. We should first wait for the results of our own SCRaTCH trial as well as the one by @metwally01 and the IPD. Then see if that's enough.. #ESHREjc

[Nienke van Hoogenhuijze @Nienke_vanH]

@samueldsribeiro @maclaudiaa They will follow soon, at the ESHRE virtual meeting! #ESHREjc

[Nienke van Hoogenhuijze @Nienke_vanH]

@MackensShari @samueldsribeiro @maclaudiaa Hopefully the IPD will provide some answers (or at least a clue where to look further).. I think the best strategy is to gather all available data and see if that gives us an answer #ESHREjc

[Nienke van Hoogenhuijze @Nienke_vanH]

@MinaNMincheva @maclaudiaa @samueldsribeiro Fully agree. At this moment there is not enough evidence to say if it does or does not work, so it should not be part of daily practice #ESHREjc

[Nienke van Hoogenhuijze @Nienke_vanH]

@juliauraji @maclaudiaa @samueldsribeiro @SofiaMakieva Blinding is indeed a problem in scratch research. Some trials perform something like this @juliauraji but as @SarahLensen described in her thesis, many women could still guess their allocation https://t.co/dr5NTbTRQQ

[Nienke van Hoogenhuijze @Nienke_vanH]

@juliauraji All good points 👆. the biological effect of scratching was unknown but we started testing its effectiveness in patients; there are so many variations possible (patient characteristics, timing, scratch device) that it’s difficult to find out what works, if it works #ESHREjc