Researchers at the University of Galway have revealed the results of a world-first study into how bowel cancer shuts down the immune system, and how this can be reversed to improve treatment. 🧬
Professor in Tumour Immunology at @galwaycmnhs Aideen Ryan, stated that unlike in melanoma and lung cancer, immunotherapy has had limited success in treating bowel cancer, leaving advanced-stage patients with few options and poor survival rates.
The breakthrough research discovery is the first to demonstrate that tumour stromal cells, which support cancer growth, are directly reprogramming the immune system. 🧫
These cells are coated in sialoglycans that bind to Siglec receptors on immune cells, switching off the body’s natural defences and making immunotherapy ineffective.
Read more 👉 https://t.co/DCM1IkbL55
@aideenryan1@researchirel@IrishResearch@BreakthroCancer@QuBelfast
#UniversityofGalway #CancerResearch #MedicalResearch
If you are interested in the role of sialylation in mediating stromal cell immunosuppression check out our new review led by @OAoise
We explore the role of the Sia/Siglec axis within stromal-rich, immunosuppressive TMEs. @MichaelodwyerMD
https://t.co/l5FQSdvAWW
A St Patrick’s Day treat ☘️
More excellent work from @aideenryan1 and her team, teasing apart the importance of stromal & immune communication networks in colorectal cancer 👇
Exciting news from #ASH24! Palleon contributed to new research showing promising ways to enhance treatment for #MultipleMyeloma. Honored to work with @MichaelodwyerMD & @aideenryan1 in advancing options for those fighting this disease.
🔗 https://t.co/9wJxE8cVA0
Could patients with stromal rich, CMS4 colorectal cancer benefit from innate immune targeting therapies? See our new paper exploring the complexe TME in CMS4 tumours, combining syngenic animal models, 3D culture systems and patient samples/datasets https://t.co/MuR7yYgl3T
Fantastic few days at #ECI2024 with the @aideenryan1 lab gang 🥳 great immunology talks. Delighted to have the opportunity to present my work in the glycosylation workshop today and to receive a bright spark award @EFIS_Immunology@yISI_ie @scienceirel
such a great experience in #ECI2024 to share my work which is CAFs subpopulation immunomodulation in CRC. Very lucky that I can work with these wonderful people. Thanks @EFIS_Immunology travel grant for supporting my trip.
Presented today at #ECI2024 on developing a 3D model to assess stromal mediated effects on T cells in the CRC TME.Enjoyed great discussions about my project.Very greatful to have received a travel grant from @EFIS_Immunology/ @EurJImmunol. Looking forward to the talks tomorrow!
Had a great day on Wednesday attending the @GalwayCMNHS research day. Was very motivational hearing about the research taking place through the college. Grateful to have received an award for the best rapid fire oral presentation.
Come join our teams @JoanneLysaght and I at @tcddublin and @uniofgalway for an exciting collaboration on immune checkpoint signalling in OAC. Great opportunity if you are interested in next generation anti-cancer immune therapies and collaborative research. @CancerUniGalway
Congratulations to the newest Dr in the Ryan lab @eileenreidy111. A privilege to work with Eileen on 3D CRC models, with co-supervisor @abhay_curam. Thanks to examiners Prof Jai Prakash, Dr Conall Dennedy and chair Prof Sharon Glynn @shazglynn@GalwayCMNHS @CancerUniGalway