Osiel Recoder

[Ming "Tommy" Tang @tangming2005]

A nice python package for creating Publication-Ready Scientific Plots https://t.co/WX2kvXtzxU

if you use R, take a look at https://t.co/HgyiQA7CbA

[Niko McCarty. @NikoMcCarty]

New book chapter: "How to Weigh a Cell."

This chapter explains how scientists have weighed cells throughout history, often using simple equipment and back-of-the-envelope calculations.

It has lots of interactives, so you can "repeat" the experiments directly in your browser.

[The Fuchs lab @ElaineFuchsLab]

Our paper is out in @ScienceMagazine
Here we describe how stem cell retain epigenetic inflammatory memory long-term. Full text in the link below!
Congratulations @chris_cowley14 @SairajSajjath @LFSoto12 and everyone else involved!
https://t.co/G2MLNwTh6D

[Waggoner Lab @LabWaggoner]

The epigenome "remembers" inflammation and primes stem cells for cancer @snaga13 @Nature @JD_Buenrostro @Harvard
https://t.co/I9OlwackI8
https://t.co/Ed9USKB6OP

[Molecular Cell @MolecularCell]

Density transitions in the regulation of transcription https://t.co/addvpubiul

[NatureStructMolBiol @NatureSMB]

New online! Global reorganization of genome architecture at the transition to gametogenesis https://t.co/VVUlt9hZNt

[Dr. Dominic Ng @DrDominicNg]

Writing forces your brain to coordinate memory, reasoning, and meaning-making simultaneously.

Every time you write, you rewire toward clearer thinking. Every time you let an LLM do it, you rewire toward consumption.

[Barkai Lab @BarkaiLab]

(1/8) Still wondering how low complexity intrinsically disordered regions (IDRs) guide transcription factors (TFs) to bind in genomes? Previous studies on sequence grammars; our new @MolCell paper takes the next step: de novo design of functional TF IDRs!
https://t.co/qJugw2V3qE

[Prof. Nikolai Slavov @slavov_n]

Is there a formula for a competitive NIH grant application?

This Perspective aims to provide an inclusive roadmap on the elements of NIH funding.

Elements of successful NIH grant applications

[Nature Reviews Molecular Cell Biology @NatRevMCB]

New Online! Organization of replicated chromosomes by DNA loops and sister chromatid cohesion https://t.co/Nkp15pYyXV

[Oz @oznova_]

This is what amino acids look like if you let the side chains flop around on the page

[Nature Reviews Molecular Cell Biology @NatRevMCB]

New Online! Critical constituents and assembly principles of centriole biogenesis in human cells https://t.co/8wkay7gIvb

[nature @Nature]

Five years ago, researchers at Google DeepMind unveiled AlphaFold2

https://t.co/0XK0t0dRm8

[Niko McCarty. @NikoMcCarty]

Here are 30 great essays about biology. I consider these to be my "personal canon," and think that they are all basically perfect in their own ways, despite being different in form and style. All have shaped my own writing considerably.

I'm not including links here, but you can easily search and find these.

1. Diagnosing the decline in pharmaceutical R&D efficiency, Jack W. Scannell et al., 2012
2. Predictive validity in drug discovery: what it is, why it matters and how to improve it, Jack Scannell et al., 2022
3. Is the cell really a machine?, Daniel J. Nicholson, 2019
4. How academia and publishing are destroying scientific innovation: a conversation with Sydney Brenner, Elizabeth Dzeng, 2014
5. A Future History of Biomedical Progress, Adam Green (Markov), 2022
6. The pharma industry from Paul Janssen to today, Alex Telford, 2023
7. The Lives of a Cell, Lewis Thomas, 1974
8. The maddening saga of how an Alzheimer’s ‘cabal’ thwarted progress toward a cure for decades, Sharon Begley, 2019
9. The Scientific Virtues, Slime Mold Time Mold, 2022
10. First Clean Water, Now Clean Air, Fin Moorhouse, 2023
11. I should have loved biology, James Somers, 2020
12. The Baffling Intelligence of a Single Cell, James Somers & Edwin Morris, 2024
13. Biology is more theoretical than physics, Jeremy Gunawardena, 2013
14. Can a biologist fix a radio?, Yuri Lazebnik, 2002
15. Cells are very fast and crowded places, Ken Shirriff, 2011
16. Life at Low Reynolds Number, E.M. Purcell, 1976
17. Lena, qntm, 2021
18. Sequences and Consequences, Sydney Brenner, 2010
19. The NIH Report, Matt Faherty, 2022 (I edited this one)
20. Simplicity in biology, Uri Alon, 2007
21. A breakthrough from 60 years ago: “General nature of the genetic code for proteins” (1961), Matthew Cobb, 2021
22. Molecular “Vitalism”, Marc Kirschner, John Gerhart, Tim Mitchison, 2000
23. The Coming Technological Singularity, Vernor Vinge, 1993
24. Review of Scientific Self-Experimentation, Brian Hanley & William Bains & George Church, 2018
25. Coming full circle-from endless complexity to simplicity and back again, Robert Weinberg, 2014
26. Nothing in Biology Makes Sense Except in the Light of Evolution, Theodosius Dobzhansky, 1973
27. The Impersonator: The Fake Data Were Coming From Inside the Lab, Uri Simonsohn, 2024
28. The Longevity FAQ, José Luis Ricón (Nintil), 2020
29. The Perfect Human is Puerto Rican, Lior Pachter, 2014
30. No Evidence of Disease, Stephanie Bourque, 2012

[Nature Reviews Molecular Cell Biology @NatRevMCB]

New Online! Mechanistic insights into cargo sorting and export from the Golgi apparatus https://t.co/e1ePhf2kCn

[Oscar Arias @OACerebro]

Enjoy!

https://t.co/27CubVJcU9

[Jan Broder Engler @JanBroderEngler]

In its first year https://t.co/j0S95nhvJa has become the go-to data viz for many life science researchers, got 620+ stars on Github, ~30K CRAN downloads, and 11 citations. Thank you for using, sharing, citing, and feedback! There is more to come 🤩

#rstats #dataviz #phd

[nature @Nature]

Nature research paper: Adenosine signalling drives antidepressant actions of ketamine and ECT

https://t.co/MxaGj7kqNp

[nature @Nature]

Scientists have created the most detailed maps yet of how our brains differentiate from stem cells during embryonic development and early life

https://t.co/h81hvjdu9h

[Prof. Nikolai Slavov @slavov_n]

The protein concentration in the cytoplasm is so high that the average protein has a water hydration shell of only ≈ 10 water molecules separating it from the adjacent protein hydration shell.