Oscar Jenkins

CEO, co-founder Rayon AI, Entrepreneur, & Start-up Expert. Dynmark founder. Mobile veteran & tech junkie. Dad, skier, climber & burner.

[Massimo @Rainmaker1973]

A new shot literally regrows knee cartilage.

Researchers at Stanford Medicine have identified a novel strategy to regenerate articular cartilage in knees and potentially prevent or treat osteoarthritis (OA).

The method targets 15-hydroxyprostaglandin dehydrogenase (15-PGDH), an age-related enzyme—or "gerozyme"—that accumulates in aging tissues and drives degeneration.

In aged mice, small-molecule inhibitors of 15-PGDH, delivered systemically or via intra-articular injection, promoted cartilage thickening and regeneration of functional hyaline articular cartilage.

This occurred without recruiting stem or progenitor cells; instead, existing chondrocytes underwent transcriptional reprogramming to a youthful state, with reduced populations of inflammatory and hypertrophic/degradative cells and expanded matrix-producing articular chondrocytes.

The inhibitors also reversed natural age-related cartilage thinning, improved joint function, and—when administered after simulated ACL injuries—strongly mitigated post-traumatic OA progression and associated pain.

Human OA cartilage explants from total knee replacements responded similarly in vitro, showing decreased degradation markers and evidence of new articular cartilage formation.

Given that an oral 15-PGDH inhibitor has already completed Phase 1 safety trials for age-related muscle atrophy, the findings open a path toward disease-modifying, regenerative therapies that could delay or obviate the need for joint replacement surgery.

[Agarwal, P., Su, S., Ancel, S., et al. (2025). Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration. Science. DOI: 10.1126/science.adx6649]

[Oscar Jenkins @OscarJenkins]

Second article in my using #VoiceAI about adding real intelligence to #ContactCenterSolutions to improve engagements as well as reduce operating costs. @rayon_ai #trucking #logistics #LoadBoard

https://t.co/NClnnqGS9H

[Oscar Jenkins @OscarJenkins]

@brad72287 @rayon_ai @brad72287 Nope, Human with all accompanying frailties:-)

[Oscar Jenkins @OscarJenkins]

At Rayon AI @rayon_ai we're breaking new ground using #voiceAI and #VirtualAgents to add intelligence to #ContactCenters. Here is the first in a series of articles "What is a Hight IQ/EQ Contact Center?"...https://t.co/ILt1ZelEsi

[Kosmos AI Technologies Inc @KosmosAITech]

My name’s Amelia. I’m another of Kosmos’ 27 totally unique personal assistants. We’re truly clever AI agents. We're all officially on the job starting TODAY. Come visit us at #TCDisrupt, Stand BI8 to find out what sets us apart from all other AI agents. #aivoice @kosmosaitech

[Kosmos AI Technologies Inc @KosmosAITech]

I’m Harry, one of 27 totally unique personal assistants at Kosmos. I’m a truly clever AI agent and officially on the job starting 2 October 2019. Come visit me at TechCrunch Disrupt to find out what sets us apart from all other AI assistants. #TCDisrupt #aivoice #aisolutions
#ai

[Alexander Stojanovic @stojanovic]

TensorFlow.js: machine learning for the web and beyond | the morning paper https://t.co/5T6F2tKCfp

[Oscar Jenkins @OscarJenkins]

Voicemail-Replacing AI Software - The Kosmos Reception Offers an Alternative to Voicemail Systems https://t.co/P8mQ1oXkW6

[Oscar Jenkins @OscarJenkins]

Well TrendHunter thinks what we're up to here at Kosmos is "FRESH" and "COOL". Thanks @trendhunter and Grace Mahas! @KosmosAITech #AIVoice #ConversationalAI #NLP #RIPVoicemail https://t.co/P8mQ1oXkW6

[Oscar Jenkins @OscarJenkins]

The Uncanny Valley Nobody's Talking About: Eerie Robot Voices - WIRED https://t.co/2WBqWq9l4i

[Oscar Jenkins @OscarJenkins]

How AI Will Rewire Us - The Atlantic....? Yep.... #Ai #NLP @kosmos https://t.co/WgQGveXLhb

[Oscar Jenkins @OscarJenkins]

Researchers create 'malicious' writing AI - BBC News US https://t.co/fjeTddKJ3c

[Oscar Jenkins @OscarJenkins]

IBM CEO Rometty: This is what could topple the whole digital economy - CNBC https://t.co/FLAOVcpLuh

[Oscar Jenkins @OscarJenkins]

It’s time to spend less time on Facebook and actually learn something - via @techreview https://t.co/PhVG0ECrFj

[Oscar Jenkins @OscarJenkins]

A fast-evolving new botnet could take gadgets in your home to the dark side - via @techreview https://t.co/jleE4Xmin8

[Oscar Jenkins @OscarJenkins]

I’ll share my thesis soon...... Researchers Discover Two Major Flaws in the World’s Computers - The New York Times... https://t.co/gOc6tMm1sE

[Oscar Jenkins @OscarJenkins]

The Internet of Things Is Going to Change Everything About Cybersecurity - Harvard Business Review https://t.co/djj1RaITqG

[Oscar Jenkins @OscarJenkins]

@crayfishX @anildash Thank you @crayfishX!!! Fond memories!

[Oscar Jenkins @OscarJenkins]

Agree..... Is there an alternative to Internet? Cybercrime: 'We've only seen the beginning,' expert warns https://t.co/5RRh0JBaQ3

[Oscar Jenkins @OscarJenkins]

I have officially exited #oldmessaging and can now focus on #newmessaging :-) RIP @dynmark