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1/n. I refuse to pay for twitter / X blue tick so this will be a long post. Bear with me. Over the last couple of weeks, it has been interesting to see that my science views are unlike many outstanding clinician scientists who I know. I do not actually practice medicine anymore
Dr Philips, we will skip the insults and answer the science.
Unlike your argument, Protocol32 is NOT for anyone with cancer, we NEVER claimed it. It is for healthy adults, especially vegetarians who run short on B12, DHA and creatine.
Our answers are below, with the source links in the 4 images.
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IMAGE 1: Cancer
We agree with the study you linked. Johnson et al. in JAMA Oncology 2018 found that the extra deaths came from patients refusing or delaying standard treatment.
No supplement should ever replace cancer treatment, and anyone on any medicine should show their doctor our label first.
The cancer paper you linked flags B6, B12, zinc and vitamin E only at many times our dose. It does not discuss NAC, vitamin C or astaxanthin.
Yuvraj beat cancer with chemotherapy. Since 2012 his foundation, YouWeCan, has screened over 1.4 lakh people for cancer and paid for hospital treatment for children whose families could not afford it.
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IMAGE 2: Liver
NIH LiverTox rates bacopa and boswellia E, unlikely to cause liver injury.
Curcumin and ashwagandha carry a real but very rare risk. Our booklet says so in print, and members get ALT and GGT tested on day 1 and day 90, for subscribers its paid by us.
You say 13 of our ingredients carry toxicity risks. Name them, with the dose at which each harm was found, and we will answer each one in public.
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IMAGE 3/4: Evidence behind all 32
19 have a randomised controlled trial behind them, 6 a pooled analysis of trials, and 1 a controlled feeding study. 6 have no trial at our dose, and we say so.
Nine sit at or near their trial dose. The rest are lower on purpose. Protocol32 is taken every day for years, while most of these trials ran for weeks or months, so we set maintenance amounts, not treatment doses. We do not claim a trial result at a dose the trial did not test.
Every one of the 32 ingridents is on the FSSAI permitted list, within its FSSAI limit.
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Why We Publish Everything
Many brands hide their doses in a proprietary blend. We print every dose, form and specification, and even what the raw material costs us.
We did that so any doctor could check our work and question it. We welcome that.
A clinical trial of Protocol32 is under way, and we will publish the results, whatever they show.
Some of your points are fair. Where we can do better, we will.
Everything is at https://t.co/mcPCCm8TOq
This is in very bad faith Yuvraj.
You are a good cricketer, you are a strong human, a cancer survivor. But you are an absolute health and science illiterate.
People like you and your business of bad science deeply damages science literacy and public health in our society. It is a pathetic.
You can be powerful allies for cancer patients and oncology societies and use your voice to educate people on evidence-based preventative care and direct cancer patients towards science-based care for improved survival outcomes.
But instead, you chose to team up with unethical businessmen - some with long degrees, lengthy certifications and in high positions without any functioning brain cell - and among them, one of the worst "health" influencers on the internet right now, the so-called cancer surgeon Arpit Bansal who is a pseudoscience sympathizer, an Ayurveda apologist and quite similar to Luke Coutinho, but with actual medical degrees wasted.
Know this first: Cancer patients who use alternative medicine die sooner, study finds - https://t.co/pvkpRmuyhC
Now coming to your product - P32
Among the 32 listed ingredients with 35+ distinct compounds in them, 13 carry documented risks of organ toxicity, mineral toxicity, capable of causing/promoting atherosclerosis inducing toxin generation, and with high rates of toxic environmental contamination.
Four ingredients - Ashwagandha, Bacopa, Curcumin and Boswellia are among the most frequently implicated botanicals in liver injury in LiverTox registries. When they come together, it is going to be disastrous.
https://t.co/Gya0Ycqdpc - The person who designed this complex formulation is really a clown.
Nearly all 30 active ingredients in this 32-ingredient supplement lack solid scientific proof for the health benefits promised on the label. First, the company's own chart admits that eight ingredients have no gold-standard human trials behind them - two are just inactive fillers, and six rely on weaker data or are added only for safety, yet are still marketed as multi-organ boosters.
At least 11 ingredients are "fairy-dusted," meaning the sachet contains only a tiny fraction of the daily dose actually proven to work in human studies.
High-level clinical and translational evidence demonstrates that several components in this sachet can actually increase cancer risk or accelerate tumor progression in healthy adults: Vitamin E (prostate cancer), combined folic acid+B12 (lung and colon cancer) and NAC, Vit E, Vit C, Astaxanthin (increase risk of cancer spread). See this paper:
Supplement Use and Increased Risks of Cancer: Unveiling the Other Side of the Coin - https://t.co/xqiDq6jL5c
Finally, the product stretches basic science by assuming that because a nutrient deficiency harms certain organs, taking extra amounts will supercharge those same organs in healthy adults who already get enough nutrients.
Your product is absolute BS just like the whole of herbal and dietary supplement industry is. Have some shame selling this nonsense to public and people with cancer.
I hope nobody accepts your stupid invite.
Dr Philips, we will skip the insults and answer the science.
Unlike your argument, Protocol32 is NOT for anyone with cancer, we NEVER claimed it. It is for healthy adults, especially vegetarians who run short on B12, DHA and creatine.
Our answers are below, with the source links in the four images.
---
IMAGE 1: Cancer
We agree with the study you linked. Johnson et al. in JAMA Oncology 2018 found that the extra deaths came from patients refusing or delaying standard treatment.
No supplement should ever replace cancer treatment, and anyone on any medicine should show their doctor our label first.
The cancer paper you linked flags B6, B12, zinc and vitamin E only at many times our dose. It does not discuss NAC, vitamin C or astaxanthin.
Yuvraj beat cancer with chemotherapy. Since 2012 his foundation, YouWeCan, has screened over 1.4 lakh people for cancer and paid for hospital treatment for children whose families could not afford it.
---
IMAGE 2: Liver
NIH LiverTox rates bacopa and boswellia E, unlikely to cause liver injury.
Curcumin and ashwagandha carry a real but very rare risk. Our booklet says so in print, and members get ALT and GGT tested on day 1 and day 90, for subscribers its paid by us.
You say 13 of our ingredients carry toxicity risks. Name them, with the dose at which each harm was found, and we will answer each one in public.
---
IMAGE 3/4: Evidence behind all 32
19 have a randomised controlled trial behind them, 6 a pooled analysis of trials, and 1 a controlled feeding study. 6 have no trial at our dose, and we say so.
Nine sit at or near their trial dose. The rest are lower on purpose. Protocol32 is taken every day for years, while most of these trials ran for weeks or months, so we set maintenance amounts, not treatment doses. We do not claim a trial result at a dose the trial did not test.
Every one of the 32 ingridents is on the FSSAI permitted list, within its FSSAI limit.
---
Why We Publish Everything
Many brands hide their doses in a proprietary blend. We print every dose, form and specification, and even what the raw material costs us.
We did that so any doctor could check our work and question it. We welcome that.
A clinical trial of Protocol32 is under way, and we will publish the results, whatever they show.
Some of your points are fair. Where we can do better, we will.
Everything is at https://t.co/mcPCCm8TOq
@hyderabaddoctor Dr Sudhir, these are the right questions, and the image answers all three.
The short version: no trial of the full formula is published yet. Ours is under way, and we will publish the results, whatever they show.
The evidence behind each of the 32 is in images 2 and 3.
@cspramesh Dear Pramesh, you asked for the evidence. Here it is.
Protocol32 is not for anyone with cancer, and no supplement should replace treatment.
Every dose, trial and journal is below. Our trial of the full formula is under way, and we will publish the results, whatever they show.
@drcheruvarun Dr Varun,
Only 4 of the 32 are B vitamins, close to the daily requirement. Together they cost us less than 1% per sachet.
The other 28, from creatine and algal DHA to CoQ10, are in the images with every dose and its evidence.