Peritoneal Dialysis International Journal

Peritoneal Dialysis International (PDI) - Official Journal of @ISPD1 #PeritonealDialysis
EIC: @NephroShah
SoMe Ed: @dr_nikhilshah
VA: @edgarvlermamd @jmteakell

[Peritoneal Dialysis International Journal @PDI_Journal]

Is burnout among people on PD associated with clinical outcomes? In a prospective cohort of 183, high cynicism was associated with transfer to HD (adjusted HR, 3.47; 95% CI, 1.14-10.58; p =.029).

#PDI #PeritonealDialysis #ISPD
@ISPD1
https://t.co/JB1Vo6twcW

[Peritoneal Dialysis International Journal @PDI_Journal]

Can a quality improvement project lower culture-negative PD peritonitis? Rates fell from 33% (45/135) to 20% (41/201) after adding a water-lysis step and increasing effluent sample volume.

#PDI #PeritonealDialysis #ISPD
@ISPD1
https://t.co/5rzaK4GHWw

[Peritoneal Dialysis International Journal @PDI_Journal]

The authors conclude that NNMT and MNAM exert protective effects in experimental peritoneal fibrosis, and that the NNMT/MNAM metabolic axis may represent a potential therapeutic target for PF.

@ISPD1
https://t.co/fMSzoUZF8y

[Peritoneal Dialysis International Journal @PDI_Journal]

A preclinical study in a rat model of peritoneal fibrosis and in primary rat mesothelial cells: NNMT overexpression and its metabolite 1-methylnicotinamide (MNAM) reduced fibrotic changes.

#PDI #PeritonealDialysis #ISPD
https://t.co/fMSzoUZF8y

[Peritoneal Dialysis International Journal @PDI_Journal]

Exogenous MNAM also reduced fibrotic changes and partially improved peritoneal transport parameters in PF rats. NNMT overexpression was accompanied by increased cGAS and STING expression in both models.

[Peritoneal Dialysis International Journal @PDI_Journal]

📚 Previously published in PDI | What characterises NTM-PD infections? In a 10-year retrospective analysis, all M. abscessus infections (n = 5) required transition to hemodialysis, vs 46% in other species.

#PDI #PeritonealDialysis #ISPD
@ISPD1
https://t.co/NDcEP4exRx

[Peritoneal Dialysis International Journal @PDI_Journal]

📚 Previously published in PDI | What is the risk of PD peritonitis in patients undergoing capsule endoscopy (CE)? Of 12 patients on PD who underwent CE alone, none experienced an episode of PD peritonitis.

#PDI #PeritonealDialysis #ISPD
@ISPD1
https://t.co/nht70rT2IM

[Peritoneal Dialysis International Journal @PDI_Journal]

From haemodialysis to peritoneal dialysis and back: A patient and family perspective on time on peritoneal dialysis.
Borg B et al.

#PDI #PeritonealDialysis
@ISPD1
https://t.co/4GegMkG5dA

[Peritoneal Dialysis International Journal @PDI_Journal]

Reducing dialysis system fragility in Japan by expanding and strengthening peritoneal dialysis: Lessons learned from the Great East Japan earthquake.
Mori T et al.

#PDI #PeritonealDialysis
@ISPD1
https://t.co/xQWN6YAtNs

[Peritoneal Dialysis International Journal @PDI_Journal]

📚 Previously published in PDI | How can mNGS aid diagnosis of PD peritonitis caused by atypical and rare pathogens? A review summarising mNGS use in recent clinical cases alongside new ISPD guidelines.

#PDI #PeritonealDialysis #ISPD
https://t.co/ob5gI4oYGx

[Peritoneal Dialysis International Journal @PDI_Journal]

The authors conclude that international guidelines for PD-associated peritonitis can continue to recommend the fixed-dose regimen for those on APD, with plasma Cmin monitoring after 3 days to assess for drug accumulation.

https://t.co/mL7KhjRECI

[Peritoneal Dialysis International Journal @PDI_Journal]

📚 Previously published in PDI | A pharmacokinetic simulation compared two IP aminoglycoside regimens for peritonitis on APD: both reached >90% optimal peak/MIC and AUC/MIC ratios on days 1 and 5.

#PDI #PeritonealDialysis #ISPD
https://t.co/mL7KhjRECI

[Peritoneal Dialysis International Journal @PDI_Journal]

Outcomes: time with peritoneal peak/MIC >10, AUC/MIC >74, and plasma Cmin. The loading-dose regimen gave IP exposures 2.5 times greater in the peritoneal compartment on day 1. By day 5, plasma Cmin was similar: 2.5-3.4 vs 2.4-3.3 mg/L (loading vs fixed).

[Peritoneal Dialysis International Journal @PDI_Journal]

The authors conclude that patient screening and assessment for home dialysis requires a comprehensive evaluation of clinical, psychosocial and logistical factors, supported by up-to-date training and education for providers and patients.

https://t.co/ZEUL72Rslb

[Peritoneal Dialysis International Journal @PDI_Journal]

📚 Previously published in PDI | A scoping review of tools and guides for screening and assessing patient suitability for home dialysis: 23 studies in adults with kidney failure met inclusion criteria.

#PDI #PeritonealDialysis #ISPD
https://t.co/ZEUL72Rslb

[Peritoneal Dialysis International Journal @PDI_Journal]

Major themes influencing screening and assessment for home dialysis candidacy: screening tools and guidelines (n=8), relative contraindications (n=4), patient or program education (n=9) and socioeconomic factors (n=2).