Proteoglycan Research

[Proteoglycan Research @PGResearch_]

Dear PG lovers, in the SI on Hyaluronan Biology, Dodd et al. reports that IL13 is a modulator of the HA matrix during lung challenge in IL13-/- mice, thereby linking IL13‐mediated HA regulation to tissue repair pathways.
https://t.co/Zbb5lwltb6

[Proteoglycan Research @PGResearch_]

Dear PG lovers, a new research paper from the team of the Ronzoni Institute in Milan has generated a novel functionalized hyaluronan, HYLACH® , that binds & suppresses Galectin‐3 function, offering a new tool to combat idiopathic pulmonary fibrosis.
https://t.co/88ZIU6ZR4X

[Proteoglycan Research @PGResearch_]

Dear PG lovers, read this lovely research paper from Hiroshi Nakato, Minnesota. Using a sophisticated genetic approach, the authors discovered that independent of sulfation, extra NDST-dependent HS structural features play key roles in tissue patterning.
https://t.co/AqLwWLh2xH

[Proteoglycan Research @PGResearch_]

Dear PG lovers, a great research paper just published in Proteoglycan Research from Fuchuan Li lab. They discovered that VAR2HP, a protein probe that recognizes a unique heparin‐like decasaccharide, has a great potential in targeted cancer therapy.
https://t.co/cAW8E8k2jI

[Proteoglycan Research @PGResearch_]

Dear fellow proteoglycan connoisseurs, check out this new research report from Masola & co-workers, University of Padova, on the role of Heparanase‐1 and MMPs in Covid‐19 and non Covid‐19 pneumonia. Hope you enjoy reading this open access paper.
https://t.co/cIM1lLNwkE

[Proteoglycan Research @PGResearch_]

Dear Proteoglycanologists, we have a new important research paper from Hiroshi Kitagawa , Kobe Japan, showing that chondroitin sulfate proteoglycans, such as biglycan, promote APRIL‐induced proliferation of triple-negative breast cancer cells.
https://t.co/GpzAgIrbRB

[Proteoglycan Research @PGResearch_]

@iozzo_v @halfnoise

[Renato V. Iozzo, MD PhD (Honoris causa) @iozzo_v]

Dear Hyaluronan lovers,
We are launching a Special Issue on Hyaluronan Biology lead by Aaron Petrey: [email protected] & Stephen Reeves: [email protected]. We aim to publish Research Articles, Brief Reports & Minireviews to be submitted by 6/30/24.

[Proteoglycan Research @PGResearch_]

Dear fellow proteoglycan enthusiasts, check out the new minireview of Hide Watanabe on Versican and versikine, an N-terminal processed form with biological activity. Hope you enjoy the reading of this open access article.
https://t.co/J5yL7KgD04

[Renato V. Iozzo, MD PhD (Honoris causa) @iozzo_v]

We just published in iScience a comprehensive review on the global impact of proteoglycan science on human diseases. We focused on their roles in neurodegenerative diseases, autophagy, angiogenesis, cancer, and infections. We hope you enjoy reading it. https://t.co/pt4xVWjl5W

[Proteoglycan Research @PGResearch_]

Dear Proteoglycanologists, we have a great research paper from S. Ricard-Blum and S. Samsonov on the interplay between the HS chains and the protein core of Syndecans 2/4. This interaction leads to changes in conformational dynamics of both syndecans.
https://t.co/Wa0Pl0hMrf

[Proteoglycan Research @PGResearch_]

Dear Fellow Proteoglycanologists, Proteoglycan Research has just published an outstanding review by Kyoko Hida lab on Biglycan & its role in both cancer & stromal cells & in regulating tumor angiogenesis, metastasis & chemoresistance.
https://t.co/VFoQMCqL6y

[Proteoglycan Research @PGResearch_]

Dear Proteoglycan lovers, we published a great research paper on Functional and Structural Insights into human NDST activities using Cryo-EM, AlphaFold2 modeling and structure-driven mutagenesis. These new data shed light on heparan sulfate maturation.
https://t.co/hP96SLuG8W

[Proteoglycan Research @PGResearch_]

@BostonChildrens

[Proteoglycan Research @PGResearch_]

We have just published a great research paper from Pyong Park's lab, Harvard, which highlights the importance of sulfated motifs in heparan sulfate that inhibit Streptococcus pneumoniae adhesion onto fibronectin and attenuate corneal infection
https://t.co/JgQuvjQ0rz

[Proteoglycan Research @PGResearch_]

Dear Proteoglycan lovers, Proteoglycan Research has just published a very interesting paper from Vince Hascall & Co-workers: A perspective on hyperglycemia-evoked intracellular hyaluronan and its effects on autophagy and the ER stress pathway. https://t.co/wYxiuiEkp1

[Proteoglycan Research @PGResearch_]

Dear Proteoglycan lovers, we have a new comprehensive review on Heparanase from Dr. Vlodavsky. This review discusses both the enzymatic and non-enzymatic functions of Heparanase. We invite you to showcase your breakthrough research on any aspect of proteoglycan biology.

[Renato V. Iozzo, MD PhD (Honoris causa) @iozzo_v]

Dear proteoglycan lovers, I am happy to announce the birth of Proteoglycan Research, a new open-access journal published by Wiley. This new journal is devoted to all research on proteoglycans, hyaluronan, sulfated-glycosaminoglycans, and related molecules. https://t.co/AoUH8PF2xC

[Renato V. Iozzo, MD PhD (Honoris causa) @iozzo_v]

Dear proteoglycan researchers, the journal is now a reality. We received several papers which are under review. The editorial board includes many renowned researchers, see URL below. SUBMIT YOUR BEST RESEARCH NOW. Contact me first if you plan to submit mini-reviews/perspectives.

[Renato V. Iozzo, MD PhD (Honoris causa) @iozzo_v]

Dear fellow proteoglycanologists, the Editorial describing the rationale for an open access journal dedicated to the biology of proteoglycans, hyaluronan and sulfated glycosaminoglycans, is out: https://t.co/6gCPbVCYNU
Submit your best work to Proteoglycan Research!