Mohammed Albishi ⌬

#UQUPharm35 || UQU alumnas🎓 || Fitness 🏋🏻|| Pharmacist @KFSHRC 💊

[Mohammed Albishi ⌬ @PHMohammed_]

Drug of choice 💉📕
بشكل بسيط وسهل للحفظ❤️💭

[عــهہ‏‏ود 🖤🎨 @aa_h05]

@PHMohammed_
السلام عليكم اخوي محمد البيشي.
عملت رسمه لصورتك وإن شاء الله تنال اعجابك 🙏🏻
وأتمنى منك تشجعني وتفرحني بمبلغ بسيط. لأن الرسم هو مصدر رزقي الوحيد لي ولعائلتي 🤍

[Mohammed Albishi ⌬ @PHMohammed_]

💊 Cyclophosphamide + Mesna

Cyclophosphamide is a widely used alkylating agent in oncology and several autoimmune conditions. However, its metabolism produces acrolein, a toxic metabolite that accumulates in the urinary tract and may lead to hemorrhagic cystitis. 🩸

🔹 How does Mesna help?
Mesna (2-Mercaptoethane Sulfonate Sodium) binds to acrolein in the urine, forming a non-toxic compound that is safely excreted, thereby protecting the bladder from chemical injury.

📌 Clinical Pearls:
• Mesna does not reduce the antitumor efficacy of cyclophosphamide.
• Most commonly used with high-dose cyclophosphamide and ifosfamide regimens.
• Adequate hydration and frequent voiding remain essential preventive measures.
• Patients should be monitored for hematuria and urinary symptoms during therapy.

✅ Key Point:
Mesna + hydration = cornerstone strategy for preventing cyclophosphamide-induced hemorrhagic cystitis while maintaining treatment effectiveness.

[Mohammed Albishi ⌬ @PHMohammed_]

G-CSF vs Pegfilgrastim: Practical Comparison in Oncology Practice
Granulocyte colony-stimulating factors (G-CSF) are essential in reducing chemotherapy-induced neutropenia, but choosing between short-acting and long-acting agents requires more than convenience alone.

🔹 Short-acting G-CSF – Filgrastim:
• Daily dosing (typically 5–7+ days).
• Flexible: can be started/stopped based on ANC recovery.
• Preferred when close monitoring is needed (e.g., BMT, unstable patients).
• Lower upfront cost, but requires repeated administration.

🔹 Long-acting G-CSF – Pegfilgrastim:
• Single dose per chemotherapy cycle.
• Self-regulating clearance (neutrophil-mediated).
• Improved adherence and patient convenience.
• Commonly used in outpatient solid tumor regimens.

🔹 Key clinical differences
• Flexibility vs convenience: Filgrastim allows dose titration; Pegfilgrastim simplifies care
• Setting: Filgrastim often preferred in inpatient/BMT settings; Pegfilgrastim in outpatient oncology.
• Timing: Pegfilgrastim should not be given within 24 hours before or after chemotherapy.
• Cost considerations: Vary by institution and biosimilar availability.

🔹 Guideline perspective:
According to American Society of Clinical Oncology and National Comprehensive Cancer Network, both agents are appropriate for primary prophylaxis in high-risk febrile neutropenia (≥20%), with selection based on patient-specific and logistical factors.

🔹 Clinical insight:
In real-world practice, the decision often comes down to patient stability, need for dose flexibility, and care setting rather than efficacy alone.
Clinical pharmacists play a key role in optimizing selection, ensuring correct timing, and balancing cost-effectiveness with patient outcomes.

[Mohammed Albishi ⌬ @PHMohammed_]

Dexrazoxane with Doxorubicin: Protecting the Heart Without Losing Efficacy

Doxorubicin is highly effective—but its dose-dependent cardiotoxicity remains a major limitation, especially at higher cumulative doses.

🔹 Role of Dexrazoxane:
A cardioprotective agent used to reduce anthracycline-induced cardiac injury.

🔹 Mechanism (clinical view):
• Chelates iron → ↓ free radical formation
• Reduces oxidative myocardial damage.
• Inhibits topoisomerase IIβ in cardiac tissue.

🔹 When to use:
• Consider in patients approaching cumulative doxorubicin doses ≥300 mg/m²
• Particularly important in patients with high cardiac risk
• Use based on institutional protocol and patient factors .

🔹 Administration (key rule):
➡️ Give Dexrazoxane IV ~30 minutes BEFORE doxorubicin
• Typical ratio: 10:1 (dexrazoxane : doxorubicin dose)
• Example: Doxorubicin 50 mg/m² → Dexrazoxane 500 mg/m²

🔹 Clinical considerations:
• Monitor for myelosuppression
• Dose adjustment may be required in renal impairment.
• Timing and correct ratio are critical for effectiveness.

🔹 Guideline perspective:
Supported by American Society of Clinical Oncology for cardioprotection in selected patients receiving anthracyclines.

🔹 Clinical insight:
Cardiotoxicity prevention is not an afterthought—it’s part of the treatment plan from the start.

Clinical pharmacists play a key role in identifying candidates, optimizing dosing, and ensuring safe integration into chemotherapy protocols.

[Mohammed Albishi ⌬ @PHMohammed_]

- مقارنة حياتك مع الاخرين هي اسهل طريق إلى الاكتئاب.

- لا يمكنك إسعاد الجميع واذا حاولت فستخسر نفسك.

- اكبر قاتل للأحلام هو الإدمان على اراء الاخرين عنك.

-المشكلة لا تكمل بالدخل المادي التي تجعل الجميع يفلس بل طريقة انفاقهم هل المشكله.

[Mohammed Albishi ⌬ @PHMohammed_]

"تــوكل على الله في كــل امورك"

قال ابن القيم رحمه الله تعالى التوكل نصف الدين والنصف الثاني الإنابة فإن الدين استعانة وعبادة، فالتوكل هو الاستعانة والإنابة هي العبادة.

[Mohammed Albishi ⌬ @PHMohammed_]

الصيدلي 💔

[Shahad🍯 @shazss__]

من جد اي مصيبة يحطوها فينا :

[Mohammed Albishi ⌬ @PHMohammed_]

في بيئة العمل قد تُهمَّش أو يُنسَب جهدك لغيرك،
لكن تذكّر: الله لا ينسى.
اعمل بإخلاص لا من أجل التصفيق، بل من أجل الأجر، رزقك ليس بيد مدير ولا تقييم، بل بيد الله.
اصبر، فكل عمل تؤديه بأمانة يُثمر يومًا ما،
ولو بعد حين. 🌿

[Mohammed Albishi ⌬ @PHMohammed_]

المريض كل يوم عند الصيدلية بدون وصفة😭😂

[Mohammed Albishi ⌬ @PHMohammed_]

لعلك سعيت، لعلك رجوت، لعلها قريبة آتيـة

[Mohammed Albishi ⌬ @PHMohammed_]

.​ سبحان الله
. ​الحمد لله​
. ​لا إله إلا الله​
. ​الله أكبر​
. ​لا حول ولا قوه إلا ﺑﺎلله​
. ​أستغفرالله​ العظيم وأتوب إليه
. ​سبحان الله وبحمده​
. ​سبحان الله العظيم​
. ​اللهم نجني من عذابك يوم تبعث عبادك
. اللهم انك عفو تحب العفو فاعف عني

[Mohammed Albishi ⌬ @PHMohammed_]

@Pharmalani الدنيا دواره كنا مبسوطين ونقولها لكم السنه الماضيه😂 لكن م زال الدوري باليد ان شاءالله 🙏🏻🏃🏻‍♂️

[Mohammed Albishi ⌬ @PHMohammed_]

@it0z2 If you have order for kcl bolus and you don't read lab results for KCL and it’s was high and enter by mistake instead of Mg for example pharmacist is last line so need to know everything literally.

[Mohammed Albishi ⌬ @PHMohammed_]

Message to you:

[Mohammed Albishi ⌬ @PHMohammed_]

مع هدوء الفجر: اللهم إجعلني لنفسي خيراً ولغيري نوراً ولمن حولي أثراً طيباً

[Mohammed Albishi ⌬ @PHMohammed_]

@bajawi1997 صيدلي ثالث حديث تخرج او خبرته اقل من سنتين بالاضافة العمل يكون بالتحضير سواء صيدلية داخلية او خارجية نادر يكون له تواصل مباشر مع المريض

صيدلي ثاني خبرة سنتين اقل شي العمل يكون جوكر شامل التحضيرات وتشيك وصرف الادوية للمريض والتواصل المباشر مع المريض واغلب مقدمين الرعاية الصحية

[Mohammed Albishi ⌬ @PHMohammed_]

@MuathSufyani انشهد