PRED4

Predicting serious drug side effects on Gastroenterology
Please note that this site is only monitored during working hours

[CLARITY IBD @clarityibd]

Week 2 @NIHRresearch.

✅84 🏥 in set up.
✅30 🏥 ready to 🟢!
✅52 patients recruited.
✅ 3500 patient packs sent.

Active #IBDresearch collaborations in 🏴󠁧󠁢󠁷󠁬󠁳󠁿 🏴󠁧󠁢󠁳󠁣󠁴󠁿 🏴󠁧󠁢󠁥󠁮󠁧󠁿

[PRED4 @PRED4research]

Following the guidance issued by the NIHR (link below), we are pausing the PRED4 study until further notice.

Thank you for your understanding at this extremely difficult time, the Exeter team are available via email to answer any queries you may have.

https://t.co/x5NcS7E80B

[Claire Bewshea @ClaireBewshea]

As of today the Exeter IBD Research admin team will be working from home. @PANTSresearch @PRED4research

[Charlie Lees @charlie_lees]

This is @PANTSresearch - collaborative UK IBD research at its best. Led tirelessly by @tariqahmadIBD + @ClaireBewshea ... driven by @DrNickKennedy + @alehins ... & many of us with brilliant sites & >1500 patients, prospective data and a gene hit of direct clinical utility.

[Edward Loftus @EdwardLoftus2]

Genetic variant influences anti-TNF immunogenicity in Crohn’s https://t.co/G2GZwjqxkt HLA-DQA1*05 essentially doubles the rate of immunogenicity @HealioGastro @AGA_Gastro

[Eric Topol @EricTopol]

The main treatment for #Crohns disease is a TNF-antibody, but many patients develop an immune response. It turns out that a common HLA allele (40% w/ European ancestry) is tied to this problem https://t.co/HlAMUZEGnB @AGA_Gastro @AmerGastroAssn #PGX

[Nick Kennedy @DrNickKennedy]

Our #GWAS of immunogenicity to anti-TNF in #Crohns has just gone online at @AGA_Gastro. Thanks to all the patients, PIs, nurses and the hard work of the @PANTSresearch team led by @tariqahmadIBD and @anderson_carl's group at @sangerinstitute! https://t.co/EbzGUKWU1z

[RAPIDIBD @PANTSresearch]

Eight years later, the pub’s still the best place for PANTS ideas. Watch this space...

[RBFT Gastro Research Team @RBFTgastroRteam]

Something we participated here at Royal Berks! Met some amazing patient over the years and it has been great to work with @PRED4research

[Anjan Dhar @anjan_dhar6]

It has been a privilege to contribute to this enormous project, as well as adjudicate some arms, and be a part of the publications arising from PRED4. Tariq Ahmad changed the world of Pharmacogenetics in IBD.@CDDFTRnI

[Charlie Lees @charlie_lees]

BRAVO @PRED4research Tariq & @ClaireBewshea - Not only transforming the pharmacogenetic landscape in #IBD, but also launching a vintage era for IBD research in the UK - collaborative, #bigdata projects - demonstrating what is possible with vision & grit on a shoestring.

[PRED4 @PRED4research]

... from 1st September 2019 as we now have enough recruits to the study we will be closing all arms except anti TNF induced skin reactions in IBD (ANTS) so please keep recruiting to ANTS! Thank you for your support 🧬😀

[PRED4 @PRED4research]

3000 patients 👩‍👩‍👦, 7 years 🗓️, 9 arms 🧬, 162 sites 🏥 later... thank you to all the patients, research nurses and PIs who have contributed to @pred4research....

[Claire Bewshea @ClaireBewshea]

Genetic Variants Associated With Thiopurine-Induced Myelosuppression in IBD https://t.co/7IluhYAmEf

[Claire Bewshea @ClaireBewshea]

@PRED4research @PANTSresearch @RDEResearch @OfficialNIHR @UKPGxStratmed

[Claire Bewshea @ClaireBewshea]

This is PANTS! A UK Longitudinal multi- centred observational study - possibly the largest of it kind investigating anti-TNF drug response /or not in Crohn’s patients.(Dr T Ahmad) @UofE_Research @RDEResearch @PANTSresearch #research #personalised

[Claire Bewshea @ClaireBewshea]

@OfficialNIHR @NIHRCRN_SWPen @NIHRCRN

[Nick Kennedy @DrNickKennedy]

First paper from PANTS, our UK-wide 1610-patient study of #antiTNF in #Crohns has been published online. Thanks to the patients, doctors, nurses & #research teams who made this possible! ⁦@gutsandgenes⁩ ⁦⁦@RDEResearch⁩ ⁦⁦@UniofExeter https://t.co/hnspUIpN8t

[Claire Bewshea @ClaireBewshea]

@PRED4research @gutsandgenes @CrohnsColitisUK

[Claire Bewshea @ClaireBewshea]

@PRED4research @RDEResearch @CrohnsColitisUK