Tim Palzkill Lab

Professor/Chair of the Dept of Biochemistry and Molecular Pharmacology at BCM. Using structural and molecular biology to answer the big questions since 1991.

[Tim Palzkill Lab @PalzkillLabBCM]

We rarely question buffers — maybe we should.
In a recent study from our lab, we show that phosphate inhibits KPC-2, underestimating enzyme activity and inhibitor potency.

Great work @DigniteN 👏 Go check it out 👇
https://t.co/v7vUqJ3XCa
@ASMicrobiology

[Tim Palzkill Lab @PalzkillLabBCM]

Long overdue shoutout to
@paoriverat, a second-year graduate student in Dr. Palzkill Lab, for earning a competitive Molecular Basis of Infectious Diseases (MBID) training grant.

[Tim Palzkill Lab @PalzkillLabBCM]

Congratulations to Michael A. Lopez, a second-year graduate student in the Palzkill Lab, for being awarded the Training Interdisciplinary Pharmacology Scientists Program (TIPS) predoctoral fellowship! Your hard work and dedication are truly commendable.

[Tim Palzkill Lab @PalzkillLabBCM]

🎓🌟 Big shout out to Dr. @postdoctorallie , Dr. Lynn Su, and Dr. Jane Park, former lab graduates, who rocked the stage at the recent hooding ceremony, donning their well-deserved hooding hats! 🎩👏 Keep shining bright, champs! 💫 #Graduation #BCM

[Allison (Allie) Judge @catalliesys]

Well, now it feels officially, officially official (I think it’s the hat)

[Tim Palzkill Lab @PalzkillLabBCM]

Congratulations to Jiayi Fan for winning first place for Poster Presentations in the BCM GSBS Symposium, great work!

[Tim Palzkill Lab @PalzkillLabBCM]

Check out our latest publication in PNAS about using large-scale deep mutational scanning to study epistatic interactions in an enzyme active site.
Great work done by @itsDrAllie.

https://t.co/fS9NYtVJqq

[Allison (Allie) Judge @catalliesys]

50,000+ enzyme variants tested. A new catalytic mechanism. A highly interconnected, substrate-dependent network of amino acid interactions discovered. Blood, sweat, tears (mine). This story has it all, folks: https://t.co/9d8zvAOpDN

@PNASNews @PalzkillLabBCM

[Tim Palzkill Lab @PalzkillLabBCM]

A happy gathering of our lab group at the Biochemistry and Molecular Pharmacology Holiday Luncheon. 🎄

[Allison (Allie) Judge @catalliesys]

Some work by my labmates @PalzkillLabBCM that I helped with during my PhD went live over the holidays! We used DNA-encoded libraries to find highly potent inhibitors of two prominent carbapenemases, NDM-1 and OXA-48.

https://t.co/utVZoGltkQ

[Tim Palzkill Lab @PalzkillLabBCM]

Check out our latest publication in the Journal of Medicinal Chemistry about the use of DNA encoded libraries to discover novel beta-lactamase inhibitors.

https://t.co/GJ6jK8s6PH

@JiayiFan217 @tgpalzkill

[Tim Palzkill Lab @PalzkillLabBCM]

Check out our recently published work on the proposed mechanism of how KPC-44 acquires ceftazidime-avibactam resistance:
https://t.co/m8NmJzealJ

[Tim Palzkill Lab @PalzkillLabBCM]

On another (totally unrelated…) note, the BCM graduate school application opens September 1st for those interested in continuing the legacy of these three newly-minted PhDs!

https://t.co/oIqAjCRTji

[Tim Palzkill Lab @PalzkillLabBCM]

We have one more defense to finish out the month! Allie Judge will defend her dissertation Thursday at noon.

[Tim Palzkill Lab @PalzkillLabBCM]

We have a second dissertation this week! Lynn Su will defend her dissertation tomorrow at 2 PM, and you can listen in person or via Zoom.

[Tim Palzkill Lab @PalzkillLabBCM]

Jane Park will be defending her thesis tomorrow at 2 PM—be sure to come by or tune in!

[Allison (Allie) Judge @catalliesys]

So happy to share this story and that I was able to play a small part in it! We discovered and validated highly potent small molecule inhibitors of the SARS-CoV-2 main protease, including variants that show resistance to current antiviral treatments.

[Communications Chemistry @CommsChem]

A new type of SARS-CoV-2 Mpro inhibitor is discovered by DNA-encoded chemical library screening, reported by @bcmhouston & @DamianYoung29 & @Srini_Chamakuri & @PalzkillLabBCM https://t.co/966Pt6Jd4O

[Tim Palzkill Lab @PalzkillLabBCM]

Dr. Cristina Materon recently published a review on polymyxin resistance mediated by MCR-1 https://t.co/NUtGVbXQcU

[Tim Palzkill Lab @PalzkillLabBCM]

Check out our recently published work from graduate student Lynn Su on Norovirus epitopes for potential vaccine targets: https://t.co/yKbAuEe85v