Dongguang Wei

Associate Clinical Professor, Department of Pathology, UC Davis Medical Center

[Elizabeth Montgomery, MD @LizMontgomeryMD]

Horrible treatment (radiation) associated epithelial changes in duodenal mucosa. The p53 can be ignored, probably reflecting upregulation rather thana mutational event. The same can be seen in the stomach.
Hutchings DA, et al PMID: 36843539; PMCID: PMC10460459.

[Elizabeth Montgomery, MD @LizMontgomeryMD]

Esophagitis dissecans (sloughing esophagitis). The detached portion of the epithelium loses its glycogen!

[Histopathology @Histo_Journal]

A distinguished group of pathologists documents the molecular profile of adenosquamous carcinoma of the gallbladder, demonstrating significant differences between this rare, aggressive tumour and adenocarcinoma. #gipathology #pathtwitter @matteo_fassan
https://t.co/Z6JBJTWyC3

[JClinPath_BMJ @JClinPath_BMJ]

Not everything “benign” behaves that way.

Pancreatic serous neoplasms are usually indolent, but his study is a reminder that some do not follow the script.

This study showed meaningful risk of progression (~28%) on follow-up, without metastasis
.
🔍 What should make us pause:
• Infiltrative growth pattern
• Solid architecture
• Ki-67 higher than expected
Together, they shift the conversation.

💡 Take-home:
Sometimes the goal isn’t to label a case as benign vs malignant,
it’s to recognize when it deserves closer attention and follow-up.

🔓 Open access — worth a read: https://t.co/xIwDIgXpzt

[Yasamin Mirzabeigi, MD @YMirzabeigi]

Our Gynecologic Pathology cases @UMiamiPathology are fascinating! Here’s a striking example of pilomatrix-like high-grade endometrial carcinoma (PiMHEC), a recently described entity mostly driven by CTNNB1 mutations. Look for solid basaloid growth with conspicuous central tumor cell necrosis, and pilomatrix-like keratinization with the hallmark ghost cells. This case also had a focal conventional FIGO grade 1 endometrioid component. IHC shows diffuse nuclear β-catenin with loss of PAX8 and ER in the pilomatrix-like component. These tumors are believed to behave aggressively.

[Felipe Templo Jr. ,MD, MBA 🕊 @thejourneymate]

Collision Tumor versus Composite Tumor versus Tumor to Tumor Metastasis Defined 🔬

[Felipe Templo Jr. ,MD, MBA 🕊 @thejourneymate]

HISTOLOGY ARTIFACTS ATLAS 🔬

(c): Dr Rakesh Kumar

[Hepatology Communications @HepCommJournal]

📑 #HBV promotes epithelial-mesenchymal transition in #HCC and liver fibrosis through JNK-mediated autophagy❗️
#OpenAccess #LiverX

https://t.co/JAmYQeFYxy

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[Human Pathology @Human_Pathology]

New in #HumPathol: Thermal resection-margin artifact mimicking goblet cell adenocarcinoma in appendectomy specimens: clinicopathologic correlation with appendiceal stump technique. https://t.co/whNN8r3mOf #pathology #PathTwitter #PathX #GIpath

[Ari M @ariabdullah1978]

A 3.5cm cervical lymph node, was excised during a total thyroidectomy. This image represents a section from that lymph node, what do you think is the Dx?

[Sanjay Mukhopadhyay @smlungpathguy]

What do you think of when you see a granuloma in a vessel wall in the lung? Watch this 51 second YouTube short to learn a quick tip!

Link: https://t.co/OC67nRHHke

[Zemplén Pataki, MD, PhD @ZemplenPataki]

Liver. What is your diagnosis? 🔎

Poll and stain clues below 🗳️👇

#PathPuzzle 🕵️‍♂️
@UMichPath #Pathology #PathX #PathTwitter

[Mark Ong @DrMarkOng]

I didn't know this was a thing until my first case 2 years ago. Picked up by an eagle-eyed colleague.

Eosinophils everywhere, in keeping with allergic nasal polyp.

Surprisingly hard to see the emperipolesis within dense inflammatory cells.

https://t.co/MjTPAQsuro

[Craig Horbinski @CraigHorbinski]

This is one of the best examples of lymphocytic #vasculitis I've seen in ages. Here you can see the lymphocytes attacking the right side of the blood vessel, with associated damage to the vessel wall. #pathology #neuropath #pathtwitter

[UMiami Pathology @UMiamiPathology]

A flare of Behçet disease, a systemic vasculitis, can result in colorectal bleeding. Small blood vessels can be affected, resulting in patchy ischemic changes.

[Arch Pathol Lab Med @ArchivesPath]

Can AI help assess macrovesicular steatosis on donor liver biopsies? Find out here 👉 https://t.co/xpNXGraS5b

#CAP #Archives #LiverPath

[Elizabeth Montgomery, MD @LizMontgomeryMD]

An example of crystal storing histiocytosis; the patient needs to be evaluated for a plasma cell disorder or other lambda-restricted B cell neoplasm.
Arnold CA, et al. Am J Surg Pathol. 2018 Oct;42(10):1317-1324. PMID: 29878935.

[Zemplén Pataki, MD, PhD @ZemplenPataki]

Pancreas. What is your diagnosis? 🔎

Poll below 🗳️👇

#PathPuzzle 🕵️‍♂️
@UMichPath #Pathology #PathX #PathTwitter