Paul B

[Paul B @PaulBr4]

@CameronJParry @tallymoney Get your shareholders sorted out. Who would open an account with tally with you as CEO?

[Sean Dent @SeanDentBsc]

In 2023, Novartis' global head of drug development said #AVCT's pre|CISION platform is doing exactly what it was designed to do: deliver a RANGE of chemotherapies across MULTIPLE different tumour types and it was demonstrating *very impressive* tolerability to-date.

All that remained was to demonstrate the common sense thesis that putting MORE of a drug KNOWN to be efficacious into a tumour would lead to enhanced efficacy. Not rocket science, "that bit has already been done ;-)".

Fast-forward 24 months to now:-
• 2-weekly dosing confirmed safe
• No MTD found despite dosing at 4x max dose strength & up to max cumulative dose of 550mg/kg
• Cardiotoxicity eliminated
• 100 - 1 tumour/plasma ratio

**• 91% DCR rate achieved in SGC
• PFS more than doubled in SGC & still improving
**
Sounds like enhanced efficacy to me, but Avacta weren't finished there...

They then bolted exetecan (the most potent topo1 inhibitor) onto pre|CISION and found
• 75x improvement in therapeutic index
• half-life extension from hrs to days
• Developed a range of linkers and capping groups to modulate drug delivery
• in-vivo multiple complete durable responses

* sounds like further efficacy signs to me, but Avacta weren't done there...

They then developed AVA6207, which delivers 2 warheads to the tumour simultaneously (just showing off now) & that also shows same the same thing which AVA6K, AVA3996 & AVA6103 have shown: that this really works.

The holy grail in cancer treatment is to target tumours and spare healthy tissue and Avacta are doing it across a range of tumour types, with a range of warheads in a range of settings.

Fast-forward to June 2026, circa 30 months since Janet's comments and it's highly likely Avacta can add the following list of achievements to it's CV

• AVA6103 proved to be safe in humans & early signs of efficacy (remember, exetecan has already overcome resistance to irinotecan and is more permeable than deruxtecan which is used in Enhertu)
* there's the word "efficacy again" 👀
• AVA6K proven safe & showing early signs of efficacy in breast cancer indication
• ODD status achieved for SGC (on- top of already having it for STS)
• Clear pathway for Accelerated approval/ FDA fast-track
• Strong efficacy signals from P1B (STS & SGC).

Now, let's remember some of the advantages pre|CISION has over ADC's:-
1. 10x cheaper to make
2. Micropeptide unseen by immune system
3. No acquired resistance or loss of target
4. None of the off-target toxicities such as pneumonitis
5. It targets FAP which is expressed in 90% of solid tumours
6. Is works by the bystander effect

So pre|CISION is far cheaper, drastically better & much more broadly applicable than ADC's which big pharma have spent £XXXBn developing. Notably, Novartis are the BP who have hitherto spent the least on ADC development which could be critical as negotiations and bids intensify.

There's a LOT more I've not said such as AVA7100 development, agreement with Tempus etc but the point I want to make here is that it's really not a question of IF Avacta get bought out, it's for how much. I think the "when" is now slowly coming into focus also.

Who blinks first because as CC said "Game Over. It works" 🍿😬

[Kent Nielsen Denmark @Kentfrihedniels]

Now the second farmer from Denmark has come forward. It's the same story about sick cows and reduced milk production. Remember that food poisoning is also taking place.

Make this go viral, please🐄🇩🇰💚

11/3 25
Kent Nielsen

[Craig Brockie @CraigBrockie]

Fenbendazole is the future of cancer treatment.

It's helped terminal cancer patients achieve complete remission when chemo failed.

Big Pharma can't patent it, so they ignore it.

Here's everything you need to know: 🧵

[Steve Grady (Lord) @SteveGrady]

How do you not understand this Richard? Tax the wealthy too much and they relocate and take the many millions that they already pay in tax with them. It’s that simple. If you can take your envious hat off for a moment, you’d totally understand. You might also thank these creative billionaires for bolstering your pension fund whilst you’re at it. Socialism never, ever works.

[Paul B @PaulBr4]

@Nigel_Farage time to apologise when you are factually wrong. Do not fall into the gutter with the rest of cabal.

[Tommy Robinson 🇬🇧 @TRobinsonNewEra]

ADMIN POST

This is a statement from Tommy's ex-wife after hearing about @Nigel_Farage's lie on LBC - that Tommy has convictions for 'violence against women':

It has been really upsetting to hear Nigel Farage has accused my ex husband Stephen Lennon of perpetrating violence against women. Having to sit down and talk to my children about these false allegations which are all over social media is not something any mother should have to do.

I have never ever been assaulted or abused by Stephen (Tommy) ever in my life. There has never ever been a call to the police about violence towards me or any other woman for that matter. Stephen (Tommy) has never ever been charged or accused of violence towards me or any other woman. These lies have to stop. Our children don't deserve to have these allegations thrown in their faces by their peers or questioned about it in their friendship groups.

Who the hell does Nigel Farage think he is? What gives him the right to spread lies and misinformation about my ex-husband? What gives him the right to upset my children with his false allegations?

I am so sick of hearing absolute lies spread about Stephen which affects our children.

Stephen isn't a perfect man, hes never claimed to be a perfect man. We have had our challenges as a family because of his activism and his journalism, that goes without saying, but I cannot, and will not have a high profile politician like Farage spread fake news about my children's dad.

The lies have to stop, they have to stop now. Nigel must apologise for what he has said. My children have endured enough lies and misrepresentations about their dad to last them a lifetime.

[Paul B @PaulBr4]

@RichardBurgon Concentrate on your constituency you clown

[John Olooney @OlooneyJohn]

Doctors Killed in Plane Crash Vowed To Release Evidence Linking mRNA to Turbo Cancer

Eight cancer doctors who dedicated their lives to saving others and blowing the whistle on the devastating turbo cancer epidemic sweeping the world have been found dead.

The bodies of six world-leading oncologists and two resident medics were found on Friday in the wreckage of a plane that plunged from the sky in Brazil and exploded in a fireball, killing all 62 people on board.

The doctors were on their way to an international conference in Sao Paolo where they were set to present their findings that mRNA and the COVID-19 vaccines are responsible for the explosion of turbo cancers and autoimmune disease wreaking havoc around the world today.

Mainstream media are working overtime to brush this story under the carpet on behalf of Big Pharma, but the facts are damning and we are not going to let them cover up the truth.

⏯ @RealWorldNewsChannel
✳️ @RealWorldNewsChat

[Rush @exRAF_Al]

Why is private healthcare giving so much money to Labour MPs and what is Wes Streeting doing for his money?

Wes Streeting £193225
Keir Starmer £157500
Stella Creasey £5000
Yvette Cooper £231817
Rachel Reeves £14840
Angela Rayner £50000
David Lammy £1640 https://t.co/Wb1sSwZcTL

[Paul B @PaulBr4]

@tom_the_bomb__ Tom. Yes it would but they haven't got an up front payment. Please try to keep actual facts.

[Paul B @PaulBr4]

@SeanDentBsc Who is the BDO please?

[Cumulus @Cumulus51896691]

Greg Alexander, who owns 75% of Conifer Management LLP reportedly manages the personal wealth of Charlie Munger. His fund is massively concentrated in just 10 stocks. And yet he is an active buyer of #avct

[Paul B @PaulBr4]

@tom_the_bomb__ #avct is not funded until early 2025. This was made clear in the latest presentation. Now if some other payment comes into the company in the meantime you may be correct.

[Tony Fawcett @tony_fawcett]

@Avacta are revolutionising the treatment of #cancer with its targeted #chemotherapy with its second pre|CISION TM drug #AVA3996 in pre-clinical research. #AVCT

#MelanomaMonday #MelanomaAwarenessMonth23 #melanoma

@CureMelanoma

[Britain People @Britain_People]

🚨SENSATIONAL UPDATE

🔴RISHI SUNAK: WIFE'S FINANCES🔴

No wonder Rishi Sunak does not want disclosure of his wife's finances. 👇

💥Take a look 👀

[Britain People @Britain_People]

🔴MICHELLE MONE

WHERE is our money, Baroness Mone?

RETWEET to refresh her memory.

#PPEScandal

[June Slater @juneslater17]

This will resonate with many people

[Paul B @PaulBr4]

Disgusting. What is going on here? This is supposed to be a democracy. Andrew Bridgen should not be silenced. He is a democratically elected MP and his views are supported by an ever growing number of people.

[Paul B @PaulBr4]

@YorkshirPuddin @Stocksniper28 @Towlie1981 Jake. He's shorting #avct and does not care about what else is on offer. If he gets his target he will go long. Just making money off people who listen to him. Interact with those who know what you are talking about.