Peersen Lab

Structural biology and biochemistry of RNA virus replication proteins, at Colorado State University.

[Peersen Lab @PeersenLab]

A new update (v4) to the polymerase structure alignments is available on Zenodo - this July 2022 release has 917 structures from 628 PDB entries. https://t.co/AcBmKGc8Fg https://t.co/R4Due4ahuT…

[Patrick Cramer @mpgpresident]

The polymerase of #coronavirus #SARSCoV2 can adopt an alternative structure: an antiparallel dimer with only one nsp8 that may bind only one nsp13. We speculate the dimer facilitates template switching and synthesis of subgenomic viral #RNA.

Manuscript: https://t.co/RiGv5eeOYr

[Peersen Lab @PeersenLab]

A long overdue update to my structure alignments - now up to 802 structures from 534 PDB entries. Includes 21 CoV nsp12 solved in the last year. Polymerase Structure Alignments - v3 Update (March 2021) https://t.co/d1eAVPFkjl

[Patrick Cramer @mpgpresident]

Our paper describing the #coronavirus RNA polymerase structure is online. The nsp8 extensions contact RNA far away from the active site, apparently enabling processive replication of the very long #SARSCoV2 genome.
Publication: https://t.co/go28YxOvaO
PR: https://t.co/bT7ig1Oyjc

[Peersen Lab @PeersenLab]

New paper on SARS nsp12 polymerase biochemistry, drug incorporation, and virology from my great sabbatical with @canardbruno @AFMBLab. https://t.co/gTuKgsvrQZ

[Decroly Etienne @DecrolyE]

Thanks to A Shannon F. Ferron and the Canard team: Remdesivir and SARS-CoV-2: structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites https://t.co/aZStEWPXKE

[American Society for Virology @AmerSocVirol]

Due to public health concerns regarding the COVID-19 pandemic, ASV 2020 has been cancelled. Please see our full statement here: https://t.co/R51JMn2ixY

[American Society for Virology @AmerSocVirol]

#ASV2020 Program and abstract submission are now live at https://t.co/1VhPhakHXU. Coming/opening soon: registration, residence hall registration, travel award and ASVCares applications, and *NEW* for 2020, onsite childcare. #LoveVirology

[Peersen Lab @PeersenLab]

@canardbruno Thanks for the shoutout, Bruno. This is an evolving project and I’m more than happy to take suggestions for new/improved alignments or analyses. It’s a resource for polymerase geeks, and perhaps some instructors.

[Peersen Lab @PeersenLab]

Polymerase Structure Alignments - v2a Update (October 2019)

New structures of L proteins from RSV and HMPV, picornaviral polymerases with a Ser1 residue, bluetongue virus polymerase, more flu structures, and a FMDV 3Dpol.

https://t.co/FX9DgJ5GK4

[Peersen Lab @PeersenLab]

@VignuzziLab One of your favorite conference venues, as I recall. If it wasn’t already sunny here in Marseille I would consider it 😄.

[Peersen Lab @PeersenLab]

My years long project aligning viral polymerase structures is finally out - details in the Viruses paper below and all the coordinates can be found on Zenodo - https://t.co/lR9D2jUfnI ... soon to be updated with the latest structures https://t.co/AbL9kcxUpz