🎙️ New #ESMO Podcast – Controversies in Upper GI Cancers
📌 Radiotherapy in borderline resectable #PDAC:
Evidence vs practice �� when does it make sense?
@NiuSanford & @BasGrootKoerkam join me to discuss a case & key trials.
🎧 Listen: https://t.co/mgtMiKFkUI
#PancreaticCancer
Excited to share our new study published in JNCI! 🧬
In >500 real-world BTC pts treated with cisplatin, gemcitabine & durvalumab, we found: ✔️ SMAD4 mut = better outcomes ❌ TP53 & TERT mut = worse survival 🔬 A new clinico-molecular score for patients
https://t.co/RS2BSYVEl7
🔬 our last study on #BTC patients
Our findings reveal key clinical and molecular factors linked to maintenance #immunotherapy with #durvalumab in advanced BTC. These insights could guide better patient selection and personalized treatments.
https://t.co/PLNiGqNl0a
Five-year OS update from the HIMALAYA study of tremelimumab plus durvalumab in unresectable HCC
@JHepatology
https://t.co/wrmzv3agRm
👉OS rate at 5 yrs: 19.6% vs 9.4%
🧐Interesting OS data for pts w/ disease control & any degree of tumour shrinkage
@myESMO@EASLedu@ILCAnews
Original Article
Outcome and management of patients with hepatocellular carcinoma who achieved complete response to immunotherapy-based systemic therapy
Scheiner et al.
#LiverX
https://t.co/uMMVd2fC0O
Clinical and molecular variables associated with early progression to checkpoint inhibitors in MSI-high metastatic colorectal cancer: a retrospective cohort study.
https://t.co/krvolqOPBc
Baanbrekende studie TRANSMET toont het aan: patiënten met uitgezaaide dikkedarmkanker naar de lever kunnen geholpen worden met een #levertransplantatie. "Voor jongere kankerpatiënten met een levertumor uit de darm betekent dit de kans op een nieuw leven."
https://t.co/DSgTQ0HQtS
Check out poster 507-TOP @EASL2024.
👉Immune- versus angiogenesis-driven response to #atezobev in #aHCC
⛔️ Resistance related to TREM2+ macros and stromal activation
❗️associated with survival
Also, best Poster Award, third year in a row, still can't quite believe it...
NIVO + IPI vs LEN (90%) or SORA as 1st line treatment for HCC #ASCO24
🤩Exciting times: More & more options in 1st line HCC
💪Clear improvement in OS with ICI based therapy & sequential therapy
🎯Now, we need biomarkers to guide treatment decisions
@myESMO@ILCA@EASL #livertwitter
Last weekend, a CCB delegation cycled the #1000km of @komop_tgkanker 🚴🚴
Together with 1250 other teams, they managed to collect almost 7M EUR to support cancer research!
Amazing effort, amazing team 🤩
Thank you Bram, Shauni, Isabelle, Lars, Alexandra, Frederik en Amelie!
Check out our #openaccess review on single-cell omics for liver cancer research including nice figures (by @PeetersFre) and an overview table of all previous efforts! @JHEP_Reports
Leuvense onderzoekers keken met single cell technologie tot op het diepste niveau van de cellen in de tumor en vonden een #biomerker die kan voorspellen of een patiënt met #leverkanker zal reageren op #immuuntherapie of niet. 🔬
Meer weten? 👉https://t.co/zxhg1ejWJd
📢📢 PAPER OUT !!
🤔What biology underlies response to #atezobev in #HCC ?
🔬scRNA and scTCR sequencing of tumour and blood samples
🔜tweetorial of the amazing @CappuynsSarah
🙏Fruitful collaboration with @LambrechtsDlab
👀#OpenAccess Paper is here: https://t.co/zohwSm3jGJ
🌟 October is #LiverCancerAwarenessMonth, a time to shed light on the various types of liver cancers. 🌟
Liver cancers originate in different liver cells, and understanding them is crucial for early detection and treatment. Knowing these types and their unique characteristics is a step towards early diagnosis and better outcomes.
Share this information to raise awareness and save lives! 💚
https://t.co/L5YehZoiVm
@EASLEUAffairs@dice_europe@EuropeLiver@ILCAnews