Pelican Expression Technology

Recombinant protein expression for vaccine development via the Pelican Expression Tech® platform & PeliCRM197® carrier protein. cGMP compliant & proven.

[Pelican Expression Technology @PelicanExpTech]

Our cGMP PeliCRM197® carrier protein is the only CRM197 available in milligram to kilogram quantities? This ensures your late-stage clinical development and commercial requirements are covered, de-risking your #supplychain and costs.

https://t.co/aPsJtuWpfD

#VaccineDevelopment

[Pelican Expression Technology @PelicanExpTech]

#DidYouKnow: Recombinant CRM197 expressed by Pseudomonas fluorescens is highly similar to #CRM197 produced by C. diptheriae? Unlike CRM197 produced by E. coli, the PeliCRM197® protein lacks N-Met residues, a common contaminant of heterologous proteins.

https://t.co/h8UvPL5B0J

[Pelican Expression Technology @PelicanExpTech]

Russ Coleman is the Director of Strain Engineering at @Ligand_LGND, managing early process development and workflow automation activities to enable high-yield production of difficult-to-express #therapeuticproteins.

#PelicanExpressionTechnology #ProteinExpression

[Pelican Expression Technology @PelicanExpTech]

Our PeliCRM197® carrier protein is produced in compliance with Current Good Manufacturing Practices (cGMP) with inspections performed by multiple global health authorities, including the US FDA, UK MHRA, India CDSCO, and Health Canada since 2011.

https://t.co/aPsJtuWpfD

[Pelican Expression Technology @PelicanExpTech]

#DidYouKnow: CRM197 has been used as a carrier protein in conjugate vaccines for over 30 years! The first vaccine to use CRM197 was approved in 1990 to protect against Haemophilus influenzae type b (Hib).

#TidbitTuesday

[Pelican Expression Technology @PelicanExpTech]

The Pelican Expression Technology® group has provided our PeliCRM197® carrier protein for vaccine development since 2011.

Together, we can combat infectious diseases & make a #globalhealth impact.

https://t.co/aPsJtuWpfD

#NationalImmunizationAwarenessMonth

[Pelican Expression Technology @PelicanExpTech]

Proteins that fail to adequately express in other cell expression systems, such as E. coli and CHO cells, have been successfully produced by the Pseudomonas fluorescens-based Pelican Expression Technology® platform.

#PelicanExpressionTechnology #ProteinExpression

[Pelican Expression Technology @PelicanExpTech]

The Pelican Expression Technology® platform integrates a variety of molecular assays to ensure the quantity and quality of proteins produced by our Pseudomonas fluorescens expression strains.

Learn more: https://t.co/YmtZRXlTOd

[Pelican Expression Technology @PelicanExpTech]

Ever wondered where the Pseudomonas fluorescens strain used to power our Pelican Expression Technology® originated?

#PelicanExpressionTechnology #ProteinExpression #TidbitTuesday

[Pelican Expression Technology @PelicanExpTech]

An anthrax vaccine candidate incorporating a #recombinantprotein optimized and manufactured by the Pelican Expression Technology® platform has shown positive immunogenicity and safety data in Phase I clinical studies.

https://t.co/xKBNQ6u9GB

#SuccessStories #clinicalstudies

[Pelican Expression Technology @PelicanExpTech]

Why choose a microbial expression system, like our Pelican Expression Technology® platform, over a mammalian system?

Other microbes, like our P. fluorescens, are cheaper and faster to grow and often produce higher yields than mammalian cells!

https://t.co/R5yLuVVc6e

[Pelican Expression Technology @PelicanExpTech]

Which features of DNA expression plasmids have you optimized to maximize your protein yield?

Our Pelican Expression Technology® platform optimizes all of these features (and more!) at once using high-throughput screening.

#ProteinExpression

[Pelican Expression Technology @PelicanExpTech]

A well-executed technology transfer for bioprocesses is critical for process and product reproducibility and quality.

Learn how we can help: https://t.co/uQE0Fp2w9C

[Pelican Expression Technology @PelicanExpTech]

It's been 12 years since the publication of our seminal paper, "Reliable protein production in a Pseudomonas fluorescens expression system," where we first described our Pelican Expression Technology® toolbox.

Give it a read here: https://t.co/U16Vz7FpAr

#ProteinExpression

[Pelican Expression Technology @PelicanExpTech]

Meet Elizabeth Orchard, PhD, a Group Lead in Fermentation at Pelican Expression Technology®!

Throughout her career, Elizabeth has developed upstream processes with various organisms, from algae to E. coli, and now Pseudomonas fluorescens!

#MeetTheTeam

[Pelican Expression Technology @PelicanExpTech]

We're taking a moment to honor the accomplishments of Dr. Janet Mertz, whose contributions to the discovery of #recombinantDNA technology laid the groundwork for #biotechnology companies like ours.

https://t.co/XbqTjbq4kS

#ProteinExpression

[Pelican Expression Technology @PelicanExpTech]

Our Pelican Expression Technology® system combines a variety of codon-optimized genes, expression vectors, and P. flourescens phenotypes to produce thousands of unique expression strains to be screened in parallel.

https://t.co/HDBmmuEviG

#ProteinExpression

[Pelican Expression Technology @PelicanExpTech]

Our Pelican Expression Technology® system's technology uses #highthroughput screening to identify strains of P. fluorescens that highly express active, soluble target proteins to use in your research and product development.

https://t.co/hsZOrcqood

#ProteinExpression

[Pelican Expression Technology @PelicanExpTech]

Experiencing difficulty expressing your #recombinantproteins?

Our Pelican Expression Technology® platform optimizes high-yield #proteinexpression candidates to ensure solubility, proper folding, and functional activity.

https://t.co/xqOKYOdYLI

#PelicanExpressionTechnology

[Pelican Expression Technology @PelicanExpTech]

Congratulations to our partner @SerumInstIndia and their collaborators! Our PeliCRM197® carrier protein is a key component in this vaccine and many others that require a consistent and robust supply.

Learn more: https://t.co/c9gAkQc7wT