Penn Medicine Division of Hematopathology

Official Penn Medicine Division of Hematopathology
Interesting cases and department contributions.
Cases not current/opinions are our own.

[Penn Medicine Division of Hematopathology @PennHemePath]

Dr. Bagg will be moderating an interactive virtual workshop organized by Curio Science focused on the pathology of AML! Please join him and other hematopathologists for this workshop by registering via https://t.co/XPFB9PWnKS.

#hemepath #hematopathology #PathTwitter

[Penn Medicine Division of Hematopathology @PennHemePath]

Congratulations to our Hematopathology Fellows, Class of 2023!!! 🎉🎉🎉

[Penn Medicine Division of Hematopathology @PennHemePath]

Congratulations to our Hemepath Fellows, class of 2022!!!🎉So Proud! They grow up so fast 🥹

[Siddharth Bhattacharyya, MD @Siddhar35280812]

Congratulations  to our hematopathology fellows!!! I know we can all expect great things in the future!!!

@PennHemePath @PennPathLabMed

[Penn Medicine Division of Hematopathology @PennHemePath]

This great opportunity is only 1 week away! Sign up below.

[Penn Medicine Division of Hematopathology @PennHemePath]

Dr. Bagg will be moderating an interactive virtual workshop organized by Curio Science focused on the pathology of AML! Please join him and other hematopathologists for this workshop by registering via https://t.co/XPFB9PWnKS.

#hemepath #hematopathology #PathTwitter

[Penn Medicine Division of Hematopathology @PennHemePath]

We're accepting applications to our Hematopathology Penn Medicine Clinician position 🔬

Apply now! https://t.co/2VConbCX6e

#hemepath #hematopathology

[Brad Drumheller, MD @BradDrumheller]

Why am I posting this classic peripheral blood smear? The answer will give you nightmares.
#hemepath #PathTwitter

[SocforHemepath @SocforHemepath]

#ISLH2021 Dr. Vinodh Pillai (@pillai_vinodh) presents his work on hematology laboratory correlates in setting of CAR T cell therapy, including a review of post-infusion morphologic changes. #hemepath

[SocforHemepath @SocforHemepath]

Dr. Stephanie Hurwitz from @PennPathLabMed @PennHemePath presented a case of TdT+ high-grade B-cell lymphoma #EAHPSH2021 #hemepath.

[Penn Medicine Division of Hematopathology @PennHemePath]

CAR T cell morphology and abs lymphocyte kinetics after infusion. Incredible work from our CHOP team!

[Blood Advances @BloodAdvances]

Absolute lymphocyte count proliferation kinetics after CAR T-cell infusion impact response and relapse https://t.co/tLOL4XrPKi

[Penn Medicine Division of Hematopathology @PennHemePath]

Final Diagnosis: Mast cell leukemia, aleukemic variant
✅Criteria for systemic mastocytosis
🦴Diffuse infiltrate of atypical mast cells comprising >20% of the marrow cellularity
🩸 <10% circulating in peripheral blood
☠️Poor prognosis (<1yr)

Kit sequencing pending

[Penn Medicine Division of Hematopathology @PennHemePath]

63 year old male presenting with B symptoms and rapid progression to multi-system organ failure.

WBC 12.8
Hb 10.1
PLT 14
76% neut
15% lymph
5% mono
2% myelo
2% metamyelo

A BM biopsy is performed.
What stains would you order?
Diagnosis on morphology?
#hemepath #PathTwitter

[Penn Medicine Division of Hematopathology @PennHemePath]

Great differentials! We withheld the elevated Tryptase level to generate discussion. Plasma cell neoplasms may rarely contain azurophilic granules, which are often larger than the fine granules here. These cells are partially degranulated. What is your diagnosis now? Note the CBC

[Penn Medicine Division of Hematopathology @PennHemePath]

@RohitGulati_RG @MushalNoor6 @pillai_vinodh @BradDrumheller @MilaGhosh318 @Siddhar35280812 @LDorka88 Yes! The IHC you requested. Thoughts? (By the time stains arrived, the patient's Tryptase level was found to be >2000)

[Penn Medicine Division of Hematopathology @PennHemePath]

@ashrafelfiky1 @BradDrumheller @MushalNoor6 @pillai_vinodh @MilaGhosh318 @Siddhar35280812 @LDorka88 CD138 would be negative

[Penn Medicine Division of Hematopathology @PennHemePath]

@alaaomran235 @MushalNoor6 @pillai_vinodh @BradDrumheller @MilaGhosh318 @Siddhar35280812 @LDorka88 These would all be negative

[Penn Medicine Division of Hematopathology @PennHemePath]

@essel_eda @Siddhar35280812 @MushalNoor6 @pillai_vinodh @BradDrumheller @MilaGhosh318 @LDorka88 Good thought
CD138 negative
SPEP and UPEP would be unrevealing in this case

[Penn Medicine Division of Hematopathology @PennHemePath]

@marypouri @MushalNoor6 @pillai_vinodh @BradDrumheller @MilaGhosh318 @Siddhar35280812 @LDorka88 That's a great thought, especially with the rapid clinical picture. We'll post some IHC shortly

[Penn Medicine Division of Hematopathology @PennHemePath]

@Construction3rd @MushalNoor6 @pillai_vinodh @BradDrumheller @MilaGhosh318 @Siddhar35280812 @LDorka88 Well done. The tryptase level was >2000

[Penn Medicine Division of Hematopathology @PennHemePath]

@KaranVeer6263 @MushalNoor6 @pillai_vinodh @BradDrumheller @MilaGhosh318 @Siddhar35280812 @LDorka88 Excellent. Sometimes plasma cells can have azurophilic granules, similar to those seen in these images. CD138 would be negative in this case. The rapid clinical decline and some other lab work pointed us in another direction.