As a final note, we point out the advantages of membrane binding and self-assembly over simpler passive mechanisms, chief among them being precise thresholding and magnitude of response.
I’m excited to finally share our new preprint! Membrane-associated assembly processes like CME function as precisely-tunable, spatially targetable, robust on/off switches that don’t require energy at decision-time.
#biophysics
https://t.co/X5EOr0m2kU
The real kicker, though: In order for this switching mechanism to be robust and functional, the component concentrations and affinities need to be tuned into fairly precise ranges. We find that evolution has done exactly that for the components of the endocytic machinery!
@AlexanderRKlotz I quite like it when a seminar opens by going through the most relevant textbook-level problem to make sure everyone is on the same page
MIssouri voters voting for abortion rights, an increase in the minimum wage, and paid sick leave, and a senator and a president who strongly oppose these things is where we are in a nutshell
@thomasahle@AdrienCorenflos@qberthet Saying this looks like magic after posting a thread of what look like a sorcerer's glyphs is at least a little bit funny