Piush Mandhane

[Piush Mandhane @PiushMan]

@theo_moraes @CHILDSTUDY @AllerGen_NCE Thanks Theo. Was my pleasure to present at SickKids.

[Piush Mandhane @PiushMan]

@RenuMandhane @magriggles @CHILDSTUDY maybe not ice cream sandwiches but home made fruit juice Popsicles would work. Moms are so smart.

[Piush Mandhane @PiushMan]

@PedsResp it's a nice use of existing data to try to answer an important question without spending money to recollect primary data

[Piush Mandhane @PiushMan]

@PedsResp different qol questionnaires used for each study

[Piush Mandhane @PiushMan]

@PedsResp really low participation rates. Affects generalizability. Neither rct powered for the primary outcome of interest

[Piush Mandhane @PiushMan]

@PedsResp it's an interesting question with relevance to canada. We have had lots of question around setting up spirometry in the community

[Piush Mandhane @PiushMan]

Call it Centre Ice. Not #icedistrict

[Piush Mandhane @PiushMan]

@MeghanAzad @JAMAPeds @PiushMan thanks Meghan. Looks like an interesting article. Over 32k participants. Wow!

[Piush Mandhane @PiushMan]

Early results encouraging. Excited to see the longer term follow up data and indications I younger age groups

[Piush Mandhane @PiushMan]

@PedsResp would be interesting to see if early RX prevents or delays pseudomonas colonization

[Piush Mandhane @PiushMan]

I wonder what the mechanism is? @PedsResp

[Piush Mandhane @PiushMan]

I suspect the non-significance for asthma (17%) versus not may be a power story.

[Piush Mandhane @PiushMan]

Would have been nice to see the spline models of lung growth in the supplement @PedsResp

[Piush Mandhane @PiushMan]

No mention of why they chose absolute value changes versus %predicted. I think it's not clear if %predicted is better. May lose effect.

[Piush Mandhane @PiushMan]

Like stratified analysis by community to control 4 cluster. Didn't see a multilevel approach although may negate the main effect @PedsResp

[Piush Mandhane @PiushMan]

interesting to see if they could refine the air pollution variables to subject primary residence zip code @PedsResp

[Piush Mandhane @PiushMan]

Really interesting article although hard to critique. A ton of online supplement material

[Piush Mandhane @PiushMan]

results are difficult to implement in clinical practice. you're left with the conclusion that patient disposition is important

[Piush Mandhane @PiushMan]

study can't help us determine what level of saturation is too low and therefore requires admission.

[Piush Mandhane @PiushMan]

Great study. Although peripheral to the main question, it would be nice to know the length of stay for the patients after their admission.