PoisonIvey365

$Tao $BTC

[Cameron.near @Cameron_Dennis_]

Yesterday's vulnerabilities are a good reminder to review your digital security! Here are few sensible precautions:

• Enable app-based (not SMS) two factor authentication
• Turn on banking transaction alerts
• Learn to identify phishing messages
• Keep devices updated
• If you use AI agents, review your GitHub access tokens and rotate any that may have been exposed

[PoisonIvey365 @PoisonIvey365]

@Pop_Collapse Fair! I will absolutely be buying in December

[PoisonIvey365 @PoisonIvey365]

@afsheenjaf This is why I strongly believe alt season will never happen again. What are you holding right now with confidence?

[PoisonIvey365 @PoisonIvey365]

@InspectorSubnet Bad actors were already doing this but now they get 41% less lol. Investors will catch on to these tactics and their alpha will tank

[PoisonIvey365 @PoisonIvey365]

@purduealum91 @afsheenjaf no clue about x402 though

[PoisonIvey365 @PoisonIvey365]

@purduealum91 @afsheenjaf As a holder I can tell you they charge a 0.5% fee on their privacy protocol transactions and use 100% of these fees to buyback their token. They are also utilizing StonkFuns Launchpad and use the high trading fees to buy ZEC and distribute these rewards to all holders

[George Ferman @Helios_Movement]

"Nutrients don't do much for ADHD".
Cool.

Something crucial to remember, no matter what intervention you want to try for your ADHD is that catecholamine synthesis proceeds as follows:

1. Tyrosine → L-DOPA by tyrosine hydroxylase (TH)
2. L-DOPA → dopamine by DOPA decarboxylase
3. Dopamine → norepinephrine by DBH
4. Norepinephrine → epinephrine by PNMT

The key cofactors for these enzymes involved in catecholamine synthesis are:

-TH requires BH4, iron and molecular oxygen.

So you need methylfolate to support the salvage pathway via dihydrofolate reductase (DHFR), which converts dihydrobiopterin (BH2) back to BH4.

Vitamin C that directly reduces the BH3 radical back to active BH4 during recycling.

Zinc and magnesium that are required by 6-pyruvoyl-tetrahydropterin synthase (PTPS) in the de novo pathway.

B2 since NADPH / NADH that are required by sepiapterin reductase (de novo) and dihydropteridine reductase

L dopa needs pyridoxal 5'-phosphate as the prosthetic cofactor for the decarboxylation.

DBH needs vitamin C, some copper and molecualr oxygen.

PNMT's key requirement is SAMe that transfers a methyl group to form epinephrine so it needs (methylated) B6, B9, B12 and choline, magnesium and B2.

And this is just the tip of the iceberg.

ADHD patients might have compromised or slowed B6-dependent enzymes for example.

The specific B6-dependent enzymes heavily implicated in ADHD include:

1. Dopa decarboxylase that converts L-DOPA into dopamine and 5-HTP into serotonin.

2. Glutamate decarboxylase (GAD) that converts glutamate into GABA.

3. Tryptophan metabolizing enzymes (think the kynurenine pathway)

“But i don’t feel anything from B6”.
A) Are you using P5P?
B) Do you have enough zinc, B2 and magnesium in your system?

Then zinc helps keep DAT at a healthy baseline, preventing it from vacuuming up dopamine too aggressively.

DAT contains four high-affinity extracellular binding sites specifically meant for Zinc.

When Zinc binds to these sites, it physically modulates the transporter’s rhythm, altering steady-state currents and optimizing reuptake.

Normally, after dopamine is released into the synaptic cleft, it binds to dopamine receptors on the postsynaptic neuron to exert its effects.

The DAT then clears the dopamine from the synapse and recycles it back into the presynaptic neuron.

So it helps to terminate the action of dopamine by transporting it back into the presynaptic neuron.

So when we inhibit it, we slow down the cleanup of dopamine and leave more of the chemical active in the synapses.

Ritalin for example is a highly effective DAT inhibitor.

Its structural mechanism differs completely from zinc obviously.

While zinc acts as a non-competitive, allosteric clamp that locks the transporter from a side-pocket, methylphenidate operates primarily as an orthosteric blocker.

It targets the S1 central binding site of the dopamine transporter.

This is the exact same internal structural pocket where the dopamine molecule itself lands to be moved across the membrane.

By sitting directly inside the central channel core, it acts like a physical plug and thus dopamine cannot bind to the transporter at all.

Now unlike competitive inhibitors (such as cocaine or Ritalin), which bind directly to the central S1 substrate site halfway across the cell membrane, zinc acts at an entirely independent allosteric site on the outer surface of the transporter.

By anchoring itself to this distinct outer pocket, zinc physically restrains the movement of the transporter.

It acts as a rigid macromolecular bridge that locks the DAT machinery in an “outward-open” conformation.

While the central channel remains open, the transporter is effectively paralyzed, it can no longer undergo the conformational rotation required to pull dopamine out of the synapse and back into the cell.

For someone struggling with ADHD or anhedonia, this highly efficient, non-competitive blocking action provides a unique therapeutic advantage.

Because zinc does not compete for the central keyhole, its ability to stop the cellular “vacuum cleaner” cannot be overridden by fluctuating concentrations of natural dopamine.

It forces a baseline level of dopamine to pool within the synaptic cleft.

This is why DAT inhibitors usually increase the effectiveness of stimulants.

In the context of ADHD, this prolonged synaptic activity helps satisfy under-stimulated reward pathways.

In the case of anhedonia this steady accumulation of active dopamine lowers the activation threshold required to feel pleasure, motivation and goal-directed drive.

Other natural DAT inhibitors that you might be aware of are ginkgo and saffron.

“What about copper?”

At basic doses such as 10-15mg/day, eating just 100 grams of beef liver/week does the trick.

“How do you have all these figured out?”

You should read this:
https://t.co/eXCNhiGzzm

[PoisonIvey365 @PoisonIvey365]

@AltcoinMillie Both are no brainers

[PoisonIvey365 @PoisonIvey365]

@SpicyGumsSol @DoeOnChain @boboillions @aixbt_agent Value is directly accrued to holders. 100% of all privacy app revenue is used to buy the Mask token, and you get ZEC rewards by holding. The owner wallet also receives ZEC which they then sell and use to buy back the Mask token

[PoisonIvey365 @PoisonIvey365]

@kale_abe @uhonyn launchpads like Stonk are helping crypto IMO. Degens are gonna degen. At least now 2-3% of every degens buy orders create buy pressure on crypto thats sticky like BTC,ZEC, SOL etc.

[PoisonIvey365 @PoisonIvey365]

@TalkingTensor How much revenue are they making?

[PoisonIvey365 @PoisonIvey365]

@LukeGiroud and what about the sharp decline in TVL?

[PoisonIvey365 @PoisonIvey365]

@Pop_Collapse How much revenue are they making?

[PoisonIvey365 @PoisonIvey365]

@tylerdurdeth @AltcoinMillie @Bitcast_network I’m a big fan of Bitcast but fyi Almanac is 1/3rd the price with more revenue

[PoisonIvey365 @PoisonIvey365]

@platopoker There is a small amount of all of those things but games haven’t been this lucrative in years

[PoisonIvey365 @PoisonIvey365]

@AlexaBliz_ 8

[const @const_reborn]

@almnc_ai Bravo @lcnxyz

[PoisonIvey365 @PoisonIvey365]

@BitcoinStrat the chain used to print more than 10x faster. Slow and steady progress my friend

[PoisonIvey365 @PoisonIvey365]

@Delphi_Sees_All @Mykland_g13 @markjeffrey I think this is a terrific idea. Instead of a person/business/agent needing to buy 3 different alpha tokens for storage/compute and inference, they can just use a single balance of gamma tokens. I am assuming each commodity will have its own price but the currency will b the same