Sebastian Pomplun

Chemist. Dad. Assistant Professor @LeidenScience @LACDR.
Drug Discovery - Novel Chemical Modalities - Combinatorial Chemistry

[Sebastian Pomplun @PomplunSeb]

@fra_grisoni @NWONieuws @TUeindhoven @molecularML Congratulations!

[Francesca Grisoni @fra_grisoni]

📢 JOB ALERT 📢

My team @molecularML is searching for a #postdoc with a background in medicinal chemistry! 👩‍🔬👨‍🔬🧪

Do you have the experience?
Are you eager to contribute to #AI for discovering new drugs?
👉Then DM me!

Funded by @ERC_Research and located at @TUeindhoven 🚀

[LED3 hub (inactive account) @LED3hub]

We had a small change in the program. The @LED3hub Lecture by Paola Picotti @Picotti_Lab was moved to February 6th, 2025.

[Muhammad Jbara @JbaraM90]

Thrilled to share our latest work on the late-stage, site-specific chemical insertion of aromatic PTMs into proteins, published today in @J_A_C_S
A big thanks to @LashuelLab for the exciting collaboration. Congratulations to Lin, Shaswati, and the team!
https://t.co/N9NGXTOtNg

[Beat Fierz @Beatfierz]

Come join us at EPFL! We are looking to fill a new position for a Tenure Track Professor in Chemical Biology! Find all info how to apply here: https://t.co/CTsBwQmeAz

[LED3 hub (inactive account) @LED3hub]

Can you simultaneously improve the potency and safety profile of a clinically used antibiotic?

The group of @NatMart_Chembio of the @LED3hub presents the guanidino lipoglycopeptide antibiotic class with potent antibacterial activity in @ScienceTM.
https://t.co/CUkH8j8XGB

[LED3 hub (inactive account) @LED3hub]

Amazing news that two projects involving @LED3hub scientists have been awarded funding through @NWOFunding Open Competition M2 grants. Congratulations to @PomplunSeb and Matthias Barz from the @LACDR as well as Sander van Kasteren from the LIC.
https://t.co/NP9zRwYdQ1

[ACS Central Science @ACSCentSci]

A focused library of site-specifically acetylated Max transcription factor analogs was chemically synthesized to dissect the role of Lys-acetylation in its DNA binding activity

NEW #ASAP by @jbaram90 @afek7afek
Read it here: https://t.co/3GvE2gvktT

[Structure based drug research @TUDarmstadt @Hausch_lab]

MC4DD: New EU consortium on drug discovery dedicated to macrocycles. 8 universities and 6 industry partner join forces to advance the science of macrocycles as drugs. More information: https://t.co/jUiqIkEzVd

[LED3 hub (inactive account) @LED3hub]

Can you improve an antibiotic that has been in clinical use for 75 years?

The group of @NatMart_Chembio of the @LED3hub addressed this question by developing bacitracin analogs with enhanced activity against vancomycin-resistant enterococci (VRE).

https://t.co/Kj9RJpkqPK

[VerhelstLab @VerhelstLab]

Our latest paper is just out in ACS Chemical Biology. Novel quenched fluorescent activity-based probes for serine proteases based on phosphinate esters. This work was part of the PhD of @KahlerJp. https://t.co/NH31fpS8JJ

[Stephan Hacker (inactive account) @StephanHacker2]

Great paper from the groups of @J_McGouran and Sander van Kasteren with first author @SeanMcK27 in @rsc_chembio. Fully-functionalized probes based on the metal chelator 8-mercaptoquinoline for affinity-based protein profiling of metal-binding proteins. https://t.co/BvJiHNuQMK

[Leiden Science @LeidenScience]

LED3’s first PhD/Postdoc symposium was a big success!🎉 Researchers from different Leiden Science institutes presented their interdisciplinary research on Early Drug Discovery.
Read more about the collaboration: https://t.co/bRd1iREUUZ
#LED3Symposium

[LED3 hub (inactive account) @LED3hub]

At the #LED3Symposium, we also announced next year's #LED3Lectures with an amazing program including @BalskusLab, Andrew Leach, Tjeerd Barf, @Picotti_Lab, @RentmeisterLab, Jeff Kelly, @johnpoverington, Kim Lewis, @TateScience and @jaykeasling.

[LED3 hub (inactive account) @LED3hub]

It was great to see all the lively discussions between researchers from all of our institutes at the poster session of the #LED3Symposium. We had a very high quality of posters with an amazing diversity of topics and a lot of interdisciplinary connections.

[Stephan Hacker (inactive account) @StephanHacker2]

Great talk by Bert Beerkens at the #LED3Symposium. He talked about his research on the development of labeling reagents for the adenosine A2B receptor using ligand-directed chemistry. Interesting application of N-acyl-N-alkyl sulfonamide (NASA) chemistry.

[LED3 hub (inactive account) @LED3hub]

Great talk by Sophie Wintermans at the #LED3Symposium. She talked about her PhD research in the group of @Martola1985 into a high throughput screening method for RNA-binding small molecules on the example of the PreQ1 riboswitch. https://t.co/Nsog2zLChI

[LED3 hub (inactive account) @LED3hub]

The final keynote lecture of the #LED3Symposium was given by @NatMart_Chembio. He talked about his group's amazing research into inhibitors of the cancer driver protein Nicotinamide N-methyltransferase (NNMT). https://t.co/CAYMH5AVoU

[LED3 hub (inactive account) @LED3hub]

Great talk by Nataliia Machushynets at the #LED3Symposium. She talked about her research in the group of @GillesvanWezel into new tridecaptin antibiotics with enhanced biological activity. An exciting interdisciplinary project across several @LED3hub groups.