Practical Neurology

Practical Neurology® magazine covers neurologic advances in epilepsy, stroke, dementia, movement disorders, headache, ALS, breaking neurology news & more.

[Practical Neurology @PracticalNeuro]

Satralizumab was associated with fewer MOGAD relapses (13.2% vs 37.5%) and greater postattack recovery in exploratory phase 3 METEOROID data presented at #MSToronto2026.

https://t.co/hyiO0bjNcR

@Roche @ECTRIMS @ACTRIMS #MOGAD #Neuroimmunology #Neurology

[Practical Neurology @PracticalNeuro]

Fenebrutinib more than halved relapse rates vs teriflunomide and improved MRI and NfL outcomes in a pooled phase 3 FENhance analysis of 1,497 patients with relapsing MS at #MSToronto2026.

https://t.co/uxHce9hsqI

@Roche @ECTRIMS @ACTRIMS #MultipleSclerosis #MSResearch

[Practical Neurology @PracticalNeuro]

Early high-efficacy DMT was associated with 36% fewer relapses in MS but did not significantly delay PIRA vs treatment escalation, according to a Danish study presented at #MSToronto2026.

https://t.co/D0oibUCxY6

@ECTRIMS @ACTRIMS #MultipleSclerosis #MSResearch #Neurology

[Practical Neurology @PracticalNeuro]

MRI activity without relapses was linked to higher risk of PIRA, SPMS, and disability worsening in MS, according to an MSBase study of 19,262 patients presented at #MSToronto2026.

https://t.co/LHT91LY1O9

@ECTRIMS @ACTRIMS #MultipleSclerosis #MSResearch #Neurology

[Practical Neurology @PracticalNeuro]

What increases the risk of late-onset epilepsy?

A new JAMA Neurology analysis of 42,257 US adults links #stroke, #diabetes, smoking, kidney disease, and #hypertension to higher epilepsy incidence after age 65. @AmEpilepsySoc @JAMANetwork

https://t.co/SW33dlwAHH

#Epilepsy #Neurology

[Practical Neurology @PracticalNeuro]

Clene has submitted an @FDA application seeking accelerated approval of CNM-Au8 as treatment for those diagnosed with amyotrophic lateral sclerosis (ALS), citing neurofilament light chain biomarker data.

https://t.co/5gyr9qDE9Y

@alsassociation

#ALS #CNMAu8 #Neurology #Neuromuscular

[Practical Neurology @PracticalNeuro]

Adults taking enzyme-inducing antiseizure medications had 51% higher adjusted odds of osteoporosis or osteopenia, yet only 20.7% had documented vitamin D supplementation, according to research presented at @ANAneurology #ANA2026.

https://t.co/RkCpSc58Zf

#Epilepsy #BoneHealth #Neurology

[Practical Neurology @PracticalNeuro]

Investigational adrabetadex was linked to preservation of neurological function for over 10 years in 2 sisters with infantile-onset Niemann-Pick disease type C. New data presented at @ChildNeuroSoc #CNSAM.

https://t.co/X0tGxHAULE

#NiemannPick #RareDisease #PediatricNeurology

[Practical Neurology @PracticalNeuro]

Pregnancy can serve as a #neurovascular stress test—and a window for #StrokePrevention.

Rodica Di Lorenzo, MD, PhD, and Katherine Singh, MD, make the case for coordinated maternal neurovascular care.
https://t.co/NCfI74ycFH
@ClevelandClinic #MaternalStroke #WomensHealth #VascularNeurology @American_Stroke

[Practical Neurology @PracticalNeuro]

Adolescents with #GeneralizedMyastheniaGravis showed sustained improvements in daily function and muscle strength through week 108 of treatment with #Imaavy.
https://t.co/uEZoXZFaJ5
#nipocalimab #gMG #Myasthenia @MyastheniaOrg @AANEMorg @JNJNews

[Practical Neurology @PracticalNeuro]

The FDA has approved a once-daily Zilbrysq (zilucoplan) autoinjector for adults with AChR antibody-positive generalized myasthenia gravis, expanding self-administration options.

https://t.co/6QLCVuVOqW

@ucb_news @MyastheniaOrg @AANmember #MyastheniaGravis #gMG #Neurology #FDAApproval

[Practical Neurology @PracticalNeuro]

What can #wearable data tell clinicians about #Parkinson's between office visits?

In our current issue, Siegfried Hirczy, MD, and Ruth B. Schneider, MD provide a practical framework for evaluating wearable technology in clinical care.
https://t.co/ZAnT2ryWKn
@URMC_Neurology @movedisorder @MichaelJFoxOrg @ParkinsonDotOrg @AANmember

[Practical Neurology @PracticalNeuro]

A diffusion MRI–based measure of cortical microstructure corresponded with the distribution of autopsy-confirmed pathology in people with #frontotemporal lobar degeneration.
https://t.co/uIKNALaOTS
@AFTDHope #FTD @AANmember @alzassociation

[Practical Neurology @PracticalNeuro]

The @US_FDA has accepted the New Drug Application for #fenebrutinib with priority review for both relapsing #multiple_sclerosis and primary progressive #MS.
https://t.co/8RSvcuGJIZ
@AANmember @mssociety @ACTRIMS @genentech

[Practical Neurology @PracticalNeuro]

Exposure to anti-#CGRP monoclonal antibodies in early #pregnancy was associated with a 42% higher adjusted risk of spontaneous abortion among individuals with #migraine.
https://t.co/MpNWhhmuqw
@ahsheadache @amfmigraine @NHF @JAMANeuro

[Practical Neurology @PracticalNeuro]

Where does #magnetoencephalography fit in presurgical #Epilepsy evaluation? Abbas Babajani-Feremi, PhD, and Giridhar P Kalamangalam, MD, DPhil, examine how #MEG can refine localization and guide invasive monitoring and surgical planning.
https://t.co/YrQimNiKY2
@EpilepsyFdn @AANmember @AmEpilepsySoc @UFNews

[Practical Neurology @PracticalNeuro]

#SurVaxM, a peptide-mimic immunotherapeutic vaccine targeting a cell-survival protein associated with cancers, was evaluated in a phase 2b trial for people with newly diagnosed #glioblastoma.
https://t.co/cbTEbNhCAK
@NeuroOnc @AANmember @MimiVax_Inc

[Practical Neurology @PracticalNeuro]

Treatment with #ecopipam was associated with a 50% lower risk of tic relapse vs placebo in pediatric patients with #Tourette syndrome; a review article highlighted sustained tic improvement after ecopipam Tx w/o clinically relevant weight gain or metabolic complications.
https://t.co/OvW4vrAbnp
@TouretteAssn @movedisorder @AANmember @ChildNeuroSoc

[Practical Neurology @PracticalNeuro]

Adaptive #DeepBrainStimulation is bringing closed-loop #neuromodulation into clinical practice.

In our current issue, Pravin Khemani, MD, examines patient selection, programming, neural sensing, and practical considerations for clinicians treating #Parkinson disease.
https://t.co/inaDYSXNiB
@movedisorder @ProvSwedish @ParkinsonDotOrg @MichaelJFoxOrg #DBS

[Practical Neurology @PracticalNeuro]

Stoke Therapeutics announced the completion of a meeting with @US_FDA addressing key elements of a planned New Drug Application for #zorevunersen, under evaluation for the treatment of children with #Dravet syndrome.
https://t.co/bzlyPjxIQB
@StokeTx @curedravet @AmEpilepsySoc