Prism Science

Prism is building the full stack of technologies and algorithms necessary to make protein motion measurable, actionable, and predictable.

[Prism Science @PrismScienceOrg]

We need new ways to understand disease & design drugs. Protein motion holds the answer.

[Prism Science @PrismScienceOrg]

Microseeding made a big difference in Katie Lu’s Mac1 crystallization screens: 8 potential hits became 54. She’s using those results to optimize crystals for experiments asking how the crystal environment affects diffuse scattering. https://t.co/qqWGe1ZFvD

[Radial @radialscience]

We are expanding the effort that began with DiffUse to build the future of open, dynamic structural biology. Today we announce @PrismScienceOrg and a renewed commitment of $20M.

https://t.co/ebVZjq58kY

[Becky Pferdehirt @beckypferdehirt]

Today, @radialscience at @AsteraInstitute is announcing an expansion of our efforts to make protein motion measurable, predictable and actionable with a $20M commitment to @PrismScienceOrg.

[Prism Science @PrismScienceOrg]

@jhdavislab @MITBiology Prism’s work will help reveal how a mutation shifts binding, stability, or activity, uncovering how function and disease actually work.

Read more: https://t.co/QElPCeNnWC

[Prism Science @PrismScienceOrg]

We have not yet tapped the full potential of cryoEM.
The method revolutionized structural bio with atomic-level detail, but has largely focused on proteins’ common lowest-energy states. With enough samples, cryoEM sees a broader energy landscape: It can capture *rare* states.

[Prism Science @PrismScienceOrg]

@jhdavislab @MITBiology We envision that shifting data banks and experimental designs from static assumptions to dynamic expectations could change biology forever.

[Astera Institute @AsteraInstitute]

Read more about Radial's support of @PrismScienceOrg from @beckypferdehirt. https://t.co/b4HToEj7Fp

[Stephanie Wankowicz @stephanie_mul]

Hear about Prism more here: https://t.co/wbOwFifNfc

[Astera Institute @AsteraInstitute]

Today we are announcing Prism, a Radial project to make protein motion measurable, predictable, and actionable. See more: https://t.co/ymqStQ7tHW

Prism will be part of our life sciences division, Radial (led by @beckypferdehirt). The team (led by @stephanie_mul) will build a new foundation of data and AI models openly with the community. We @AsteraInstitute are excited to announce a $20M commitment to Prism’s effort: rebuilding the scientific pipeline around how proteins actually move and function

[Prism Science @PrismScienceOrg]

Prism is building the full stack of technologies and algorithms necessary to make protein motion measurable, actionable, and predictable. Coordinated change to transform the field of structural biology.

[Prism Science @PrismScienceOrg]

We need new ways to understand disease & design drugs. Protein motion holds the answer.

[Prism Science @PrismScienceOrg]

Last century, structural biology relied on a motionless view of proteins. Today’s instruments & ML no longer have to.

Prism will make protein visible, revealing how form creates function.

See more: https://t.co/14QvDCNK3Q

[Prism Science @PrismScienceOrg]

Diffuse scattering is hard to compare quantitatively across experiments, let alone across synchrotrons.

A new DiffUSE Project update shows diffuse maps reproducing across CHESS and ALS. Read the project update: https://t.co/biv1ThsTOn

[Prism Science @PrismScienceOrg]

Diffuse scattering can encode correlated protein motions, but standard pipelines often discard it as background. mdx2 is an open-source Python toolkit for carrying that signal through processing. Read @meisborg.bsky.social's overview and try mdx2: https://t.co/bPLRtEEt0k

[Stephanie Wankowicz @stephanie_mul]

Methods development is usually sequential. Collect, process, model, encode, interpret. Each stage waits on the last.

@diffUSEproject tackled it all at once. That is what it takes to transform the field and unlock protein dynamics. See more: https://t.co/TsAsPnKF1w

[Prism Science @PrismScienceOrg]

Same mission, but an expanded vision for revolutionizing structural biology to better capture protein motion. Launching September 8.

[Stephanie Wankowicz @stephanie_mul]

New TTPD podcast drop! https://t.co/ffWCYdDxxr