Simon J. Clark

Helmut Ecker Endowed Professor of AMD & Co-Founder - Complement Therapeutics. A British Biochemist in Europe 🇬🇧 🇪🇺 @prof-clark.bsky.social

[Simon J. Clark @ProfClark]

New study identifies tissue-resident choroidal macrophages as key guardians against AMD, linking their loss to complement-driven retinal degeneration. #AMD #Immunology #Complement #Macrophages #Retina #Ophthalmology #VisionResearch #Aging https://t.co/8tL0Payxvw

[Simon J. Clark @ProfClark]

A distinct genetic AMD subtype emerges: rare CFH/CFI variants are linked to earlier geographic atrophy and severe drusen burden. #AMD #GeographicAtrophy #Genetics #PrecisionMedicine https://t.co/OJFMcGm0dg

[Simon J. Clark @ProfClark]

I'll be chairing a session at this years ISER meeting in Valencia on 'The role of opsonisation and phagocytosis in ocular immune homeostasis' 23rd to 27th August in Valencia Spain! https://t.co/Em7RdFRpTh

#Ophthalmology #ISER #retina #AMD #phagocytosis #microglia #macrophage

[Anna Blom @annamariablom]

Please do not forget to nominate!
https://t.co/s5OowDJrOs

[Simon J. Clark @ProfClark]

Out new retinal multi-omics study maps 1.48M eQTLs and links rare non-coding variants to AMD & IRDs. #Genomics #Ophthalmology #RNAseq #PrecisionMedicine

https://t.co/CuS4DQws2q

[Simon J. Clark @ProfClark]

36-month data show pegcetacoplan slowed subfoveal GA progression by up to 31%, reinforcing complement inhibition in AMD. #Ophthalmology #Retina #AMD https://t.co/28oTgRL9p3

[Simon J. Clark @ProfClark]

I'll be chairing a session at this years ISER meeting in Valencia on 'The role of opsonisation and phagocytosis in ocular immune homeostasis' 23rd to 27th August in Valencia Spain! https://t.co/Em7RdFRpTh

#Ophthalmology #ISER #retina #AMD #phagocytosis #microglia #macrophage

[Simon J. Clark @ProfClark]

Welcome to Katia Ihadadene, who starts her PhD journey through the #Limits2Vision programme, studying the impact of damaged Bruch´s membrane on RPE metabolism, and how underlying genetic risk may alter this response.
#VisionScience #Neuroscience #Collaboration #PhDJourney

[Simon J. Clark @ProfClark]

New: THN391 — a single antibody that blocks neuroinflammation in Alzheimer's, MS & macular degeneration, without disrupting blood clotting. First-in-class. 🧠👁️
#Neuroscience #Biotech #AlzheimersResearch https://t.co/t8COKVR0h4

[Simon J. Clark @ProfClark]

Aging ECM alone can drive AMD-like pathology—new human Bruch’s membrane model reveals complement activation & lipid buildup. #Aging #AMD #Ophthalmology #ECM #Complement #DrugDiscovery https://t.co/i0c6GGrf3O

[Simon J. Clark @ProfClark]

Study finds AR visual noise may improve sight in AMD, pointing to a novel non-invasive digital therapy for vision loss. #DigitalHealth #MedTech #AMD https://t.co/LcA5lvHGo8

[Simon J. Clark @ProfClark]

🚀 Ray Therapeutics raises $125M for genetic eye therapies targeting blindness. Strong signal for gene therapy and bold biotech innovation. 👁️✨ #Biotech #GeneTherapy #VisionRestoration https://t.co/lUHGGp4pes

[Simon J. Clark @ProfClark]

Complement Factor H as a Novel Predictive Biomarker for Deep Vein Thrombosis Recurrence: A Prospective Cohort Study https://t.co/YqGqRRQCpd

[Simon J. Clark @ProfClark]

Single-Cell Gene Expression and eQTL Analyses in the Human Retina, RPE, and Choroid in Macular Degeneration https://t.co/QUQz2ZcSfC

[Simon J. Clark @ProfClark]

Human retinal organoid model of disease-relevant photoreceptor cell death amenable to drug screening https://t.co/G5n2jl9U1a

[Simon J. Clark @ProfClark]

While one may 'fail' to achieve a primary outcome, the generation of data is never a failure. We can all learn and improve from data reported in these trials.

FDA urges clinical trials report results https://t.co/HxhxpyEDtU

#clinicaltrials #clinicaltrials.gov #FDA #BioTech

[Simon J. Clark @ProfClark]

Previously overlooked: a novel, potent factor B inhibitor scaffold enters phase 3 for PNH, emerging as a potential rival to Iptacopan and advancing complement-targeted therapeutics. #DrugDiscovery #Complement #PNH #Pharma https://t.co/uuIhfZJbdZ

[Simon J. Clark @ProfClark]

New study reveals FHR-1 as both a driver of complement-mediated injury in IgAN and a novel therapeutic target, reshaping disease biology and treatment strategies. #IgAN #Nephrology #ComplementSystem #Immunology #MedTwitter
https://t.co/nYUp45fWG1

[Simon J. Clark @ProfClark]

Metabolomics + genetics reveal a powerful new way to predict AMD risk at population scale—linking systemic biology to eye disease. #AMD #Metabolomics #Genomics #AI #PrecisionMedicine #MedTech #PublicHealth https://t.co/YCfqt0YP0z

[Simon J. Clark @ProfClark]

AI-driven retinal imaging reveals intraretinal fluid as a key early biomarker predicting vision gains in nAMD—advancing precision treatment. #AI #Ophthalmology #AMD #MedTech #DigitalHealth #PrecisionMedicine https://t.co/U2LKqwLMpS