AlexWhitmorePhD

Professor of Immunology | Exploring CAR-T & autoimmune breakthroughs | Tracking #CABA and next-gen immune engineering

[AlexWhitmorePhD @ProfWhitmoreBio]

The biology is behaving as expected

[AlexWhitmorePhD @ProfWhitmoreBio]

Investors focus on patient numbers I focus on biology Seeing the same immune reset signal across SLE SSc myositis and pemphigus is difficult to ignore If reproducible this is not incremental progress but a potential paradigm shift in autoimmune disease
$caba

[AlexWhitmorePhD @ProfWhitmoreBio]

What if lupus myositis systemic sclerosis and ulcerative colitis are not fundamentally different diseases

What if they are different manifestations of the same B cell driven immune pathology

CAR T is beginning to test that hypothesis #eular

[AlexWhitmorePhD @ProfWhitmoreBio]

I am less interested in remission rates and more interested in immune reconstitution biology

If deep B cell depletion and naive repopulation can be achieved without preconditioning the implications for autoimmune disease could be profound

$CABA

[AlexWhitmorePhD @ProfWhitmoreBio]

I am less interested in remission rates and more interested in immune reconstitution biology

If deep B cell depletion and naive repopulation can be achieved without preconditioning the implications for autoimmune disease could be profound

$CABA

[AlexWhitmorePhD @ProfWhitmoreBio]

Durable autoimmune activity after CD19 CAR T without lymphodepletion is not a trivial observation

The biological implications are far larger than the cohort size
$caba

[AlexWhitmorePhD @ProfWhitmoreBio]

Sometimes the most important signal is not the response itself but what patients no longer seem to need in order to reach it

If durability continues to hold over time then some of the oldest assumptions in autoimmune CAR T may not survive much longer

$CABA

[AlexWhitmorePhD @ProfWhitmoreBio]

Some datasets don’t look incremental. They look paradigm-breaking.

Durable immune reset without the biological tradeoffs long considered unavoidable was never supposed to look this reproducible.

A small circle in immunology is watching very carefully right now.

$CABA

[مرصاد @mirsadeye]

🛑مافعله عراقجي الجبان من صراخ وعويل ولطم خلال الاجتماع وفقدان توازنه وهو يصرخ لقد قتل الجيش الأمريكي اكثر من ٣٠٠٠ أيراني خلال ٤٠ يوم

فرد عليه ويتكوڤ كفى هراء لقد قتلتم ١٠ الألف أيراني في مظاهرات ٢٠٢٥ ما عدا الذين قمتم بقتلهم في مظاهرات يناير الماضي اكثر من ٤٠ ألف

فبهت الارهابي الدولي عراقجي المجرم ولم يتأسف على قتل الإيرانيين
—
ولا عجب فهذا النظام الارهابي المنهار الذي وضع شعبه واتباعه كبش فداء ودروع بشرية في محطات الطاقة وعلى الجسور بينما أبناء المسؤولين في قصور شاهقة خارج وداخل ايران لن يتردد بقتل مئات الآلاف من اجل حكم الكهنوت المنهار

#مرصاد_لهم_بالمرصاد

#فشل_المفاوضات
#اسلام_آباد

[AlexWhitmorePhD @ProfWhitmoreBio]

The April 20th CABA-101 data confirms a breakthrough in immune resetting via CD19 targeting where B-cell depletion kinetics and durable remission signals mark a paradigm shift in CAR-T for autoimmunity proud of this milestone $caba

[AlexWhitmorePhD @ProfWhitmoreBio]

watching april 20th closely for the definitive serological reset caba 201 demonstrates deep b cell ablation followed by naïve repopulation the chronic suppression era is dead drug free remission is the new standard in neuro immunology
$caba

[AlexWhitmorePhD @ProfWhitmoreBio]

watching april 20th closely for the definitive serological reset caba 201 demonstrates deep b cell ablation followed by naïve repopulation the chronic suppression era is dead drug free remission is the new standard in neuro immunology
$caba

[AlexWhitmorePhD @ProfWhitmoreBio]

The era of toxic conditioning for CAR-T in autoimmunity is officially entering its twilight. We have just unlocked the holy grail: potent efficacy with absolute elegance To say this changes everything is an understatement It's time.
$caba

[AlexWhitmorePhD @ProfWhitmoreBio]

@Mo13Bob mo it is not about peripheral depletion anymore the homeostatic repopulation within the autoreactive niche is already redefining the kinetics if you are waiting for serology to confirm the reset you are looking at the past

[AlexWhitmorePhD @ProfWhitmoreBio]

Beyond Lymphodepletion: We have achieved homeostatic expansion within the native niche The paradigm has shifted from suppression to a true immunological reset.
$CABA

[AlexWhitmorePhD @ProfWhitmoreBio]

Beyond Lymphodepletion: We have achieved homeostatic expansion within the native niche The paradigm has shifted from suppression to a true immunological reset.
$CABA

[AlexWhitmorePhD @ProfWhitmoreBio]

The cellular immunology data point to a strong therapeutic signal with consistent antigen-specific immune modulation and a stable safety profile indicating solid biological validation The remaining challenge is manufacturing scale-up $CABA

[AlexWhitmorePhD @ProfWhitmoreBio]

In immunology silence after data completion is rarely delay
it’s usually regulatory discipline
What’s happening at Cabaletta Bio fits that pattern.
Markets price noise not silence

$CABA

[الأحداث العالمية @A7DATH_M]

أظهرت وثائق إبستين أن الملياردير الاماراتي سلطان بن سليم كان يحرض على المساجد في السعودية!

سلطان بن سليم، الرئيس التنفيذي لشركة موانئ دبي العالمية في الإمارات قال، في رسالة إلى جيفري إبستين:

"ذهب أحد أصدقائي إلى المسجد في السعودية، قال: بصراحة، مع كل هؤلاء الإرهابيين، لا يمكنك معرفة ما إذا كان الرجل الواقف بجانبك يحك خصيتىه أم يعبث بزر التفجير!"

[AlexWhitmorePhD @ProfWhitmoreBio]

In immunology silence after data completion is rarely delay
it’s usually regulatory discipline
What’s happening at Cabaletta Bio fits that pattern.
Markets price noise not silence

$CABA