PROSPECTOR Trial

[PROSPECTOR Trial @ProspectorTrial]

🧪 A step forward in de-labeling and precision allergy care.
📍 Multicenter | 🔍 Real-world impact | 💊 Antibiotic stewardship
Stay tuned for updates! #DrugAllergy #Penicillin #AllergyResearch #PROSPECTORTrial

[Jason Trubiano 🆔 @TrubianoJason]

🚨Primary Care Physicians 🚨 Join #DHS2026: Challenging Evidence 🧠💊
📍 Melbourne | 📅 23–25 Oct
✔️ Primary care–focused sessions
✔️ Practical skills and cases
✔️ Global experts + real-world insights
Bring #drugallergy #antibioticallergy knowledge and care into your practice.
👉 https://t.co/hO2Tb3w0IS
@RACGP #GPeducation #PrimaryCare #CPD @TheDohertyInst @EAACI_HQ

[PROSPECTOR Trial @ProspectorTrial]

What an incredible morning in Antwerp! 🇧🇪 PROSPECTOR-2 Investigator Meeting brought together a global team united by one mission — transforming testing for penicillin allergy. The work continues! #PROSPECTOR #PenicillinDelabeling #AntibioticStewardship

[PROSPECTOR Trial @ProspectorTrial]

Excited to have hosted a PROSPECTOR-2 Investigator Meeting in Antwerp today! 🌍 Investigators from countries across Africa, Asia, Australia, Canada & Europe came together. Grateful for this incredible team. #DrugAllergy #PenicillinAllergy #ClinicalTrials #PROSPECTOR

[PROSPECTOR Trial @ProspectorTrial]

Excited to share the PROSPECTOR-1 pilot, published in @NEJMEvidence! Is a 5-day prolonged oral amoxicillin challenge feasible and safe for evaluating delayed #PenicillinAllergy? The answer is yes. https://t.co/9bNvnVzLue #DrugAllergy #PROSPECTORTrial #AntibioticStewardship

[Jason Trubiano 🆔 @TrubianoJason]

Big few weeks with #PENFAST making it to Hollywood 🎥… but this might be even better 👇

The @ProspectorTrial #PROSPECTOR1 Trial led by @Austin_Health and @TheDohertyInst is now published in @NEJMEvidence 🔥

➡️ https://t.co/fwc4dKj17r

✅ First double-blind, placebo-controlled trial in #drugallergy
✅ Pilot feasibility RCT (n=120)
✅ Single-dose vs 5-day amoxicillin challenge in delayed/unknown #penicillinallergy
It was feasible and safe — and showed a 6.7% increase in immune-mediated reactions in the (multi-dose) arm.

Nice Editorial:
➡️ https://t.co/p9U85Kox2M

We’re getting closer to answering the question…

Is one dose ever enough? 👀
#PROSPECTOR2 now recruiting (doi: 10.1136/bmjopen-2024-094712)

[PROSPECTOR Trial @ProspectorTrial]

📍 Conducted across multiple centers, the PROSPECTOR trial strengthens the case for standardized protocols in penicillin allergy evaluation.
Let’s harmonize care.
#AllergyGuidelines #PROSPECTORTrial

[Jason Trubiano 🆔 @TrubianoJason]

Check out the program for #DHS2026 @EAACI_HQ @TheDohertyInst 😳😍All things #drugallergy and #antibioticallergy.
See you in Melbourne!! ☕️🦘☀️🇦🇺
🔜 https://t.co/5MCs3SRAoK


[PROSPECTOR Trial @ProspectorTrial]

🔍 Did you know?
PROSPECTOR helps us move beyond assumptions. What is the role of prolonged penicillin drug challenge?
#DrugAllergy #EvidenceBasedMedicine

[PROSPECTOR Trial @ProspectorTrial]

👩‍⚕️ Clinicians: Should we consider prolonged penicillin challenge for patients with unclear histories?
PROSPECTOR will answer this important clinical question
#ClinicalImmunology #AllergyToolkit

[Jason Trubiano 🆔 @TrubianoJason]

Is one dose ever enough? @ProspectorTrial will answer - A international double blind placebo controlled trial of 1 dose vs 5 day for #penicillinallergy. This week we recruited our 100th patient. @CAAR_Aus @Austin_Health @TheDohertyInst

[Jason Trubiano 🆔 @TrubianoJason]

@ProspectorTrial activated in 🇨🇦 with @AnaCopaescu leading at @mcgillu - our 2nd international site 🌎 #isonedoseenough #penicillinallergy @Austin_Health @CAAR_Aus @TheDohertyInst

[Florin-Dan Popescu @FlorinDanPopesc]

📢Prolonged versus single dose in penicillin oral challenge testing @ProspectorTrial 👏👏👏@TrubianoJason @AnaCopaescu @lenehgarvey @mcgillu #isonedoseenough #penicillinallergy @Austin_Health @CAAR_Aus @TheDohertyInst
https://t.co/3rM71YaH63

[PROSPECTOR Trial @ProspectorTrial]

🧪 PROSPECTOR trial highlights the importance of standardized protocols in drug allergy.
#PrecisionMedicine #PenicillinAllergy

[Jason Trubiano 🆔 @TrubianoJason]

Our first patient recruited in 🇨🇦 by @AnaCopaescu for the @ProspectorTrial trial 😆! #isonedoseenough

[PROSPECTOR Trial @ProspectorTrial]

📊 Multicentre data from PROSPECTOR to follow.
Is prolonged penicillin challenge a valuable tool?
Improved safety, better outcomes, and fewer false labels.
#DrugHypersensitivity #PROSPECTORTrial

[PROSPECTOR Trial @ProspectorTrial]

💊 1 in 10 patients report penicillin allergy — but most aren't truly allergic.
The PROSPECTOR study focuses on the role of extended penicillin evaluation.
#AntibioticStewardship #AllergyResearch

[PROSPECTOR Trial @ProspectorTrial]

🚨 PROSPECTOR trial!
What is the role of prolonged penicillin allergy evaluation?
Time to rethink how we label drug allergies.
#DrugAllergy #Penicillin #PROSPECTORTrial

[PROSPECTOR Trial @ProspectorTrial]

"Prolonged penicillin allergy evaluation: a multicentre prospective cohort study (PROSPECTOR)"
Published protocol available here - BMJ Open 2025;15:e094712. doi:10.1136/bmjopen-2023-094712

[PROSPECTOR Trial @ProspectorTrial]

🚨 New Trial Alert
We’re excited to share the launch of the PROSPECTOR Trial, exploring the safety and diagnostic value of prolonged penicillin challenge in patients with suspected drug allergy.